HUMAN:TRAF3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TRAF3 (synonyms: CAP1, CRAF1)
Protein Name(s)	TNF receptor-associated factor 3 CAP-1 CD40 receptor-associated factor 1 CRAF1 CD40-binding protein CD40BP LMP1-associated protein 1 LAP1
External Links
UniProt	Q13114
EMBL	U15637 U19260 L38509 U21092 BX247977 AK303172 AL117209 BC075087 BC075086 AF110908
CCDS	CCDS55946.1 CCDS9975.1
PIR	A55960 S68467
RefSeq	NP_001186356.1 NP_003291.2 NP_663777.1 NP_663778.1 XP_011535420.1
UniGene	Hs.510528
PDB	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
PDBsum	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
ProteinModelPortal	Q13114
SMR	Q13114
BioGrid	113039
DIP	DIP-6222N
IntAct	Q13114
MINT	MINT-1144408
STRING	9606.ENSP00000376500
PhosphoSite	Q13114
BioMuta	TRAF3
DMDM	116242824
MaxQB	Q13114
PaxDb	Q13114
PRIDE	Q13114
Ensembl	ENST00000392745 ENST00000539721 ENST00000560371
GeneID	7187
KEGG	hsa:7187
UCSC	uc001ymc.2 uc010txy.2
CTD	7187
GeneCards	TRAF3
HGNC	HGNC:12033
HPA	HPA002933 HPA050176
MIM	601896 614849
neXtProt	NX_Q13114
Orphanet	1930
PharmGKB	PA36710
eggNOG	NOG239194
GeneTree	ENSGT00550000074359
HOVERGEN	HBG058222
InParanoid	Q13114
KO	K03174
OMA	FCETCMA
OrthoDB	EOG7966G5
PhylomeDB	Q13114
TreeFam	TF321154
Reactome	R-HSA-5602571 R-HSA-5668541 R-HSA-5676594 R-HSA-918233 R-HSA-936440 R-HSA-936964
SignaLink	Q13114
ChiTaRS	TRAF3
EvolutionaryTrace	Q13114
GeneWiki	TRAF3
GenomeRNAi	7187
NextBio	28176
PMAP-CutDB	Q13114
PRO	PR:Q13114
Proteomes	UP000005640
Bgee	Q13114
CleanEx	HS_CAP1 HS_TRAF3
ExpressionAtlas	Q13114
Genevisible	Q13114
GO	GO:0035631 GO:0009898 GO:0005829 GO:0005768 GO:0005739 GO:0016874 GO:0019903 GO:0004871 GO:0031996 GO:0005164 GO:0031625 GO:0004842 GO:0008270 GO:0006915 GO:0045087 GO:0002756 GO:0032088 GO:0032480 GO:0042981 GO:0001817 GO:0050688 GO:0032648 GO:0030162 GO:0007165 GO:0008063 GO:0034138 GO:0034142 GO:0002224 GO:0035666 GO:0033209
Gene3D	2.60.210.10 3.30.40.10 3.90.890.10
InterPro	IPR002083 IPR013323 IPR012227 IPR008974 IPR027128 IPR001841 IPR013083 IPR017907 IPR001293
PANTHER	PTHR10131:SF72
PIRSF	PIRSF015614
SMART	SM00061 SM00184
SUPFAM	SSF49599
PROSITE	PS50144 PS00518 PS50089 PS50145

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0019903	protein phosphatase binding	PMID:23871208^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y2R2	F	occurs_in:(CL:0000782)	Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:11728344^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NP84	F		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	C		Seeded From UniProt	complete
involved_in	GO:0050688	regulation of defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:20185819^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032648	regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:20185819^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	PMID:11279055^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93009	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11279055^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O94972	F		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	PMID:20185819^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60803	P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107548 MGI:MGI:108041 PANTHER:PTN000805720	C		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108041 PANTHER:PTN002562108 UniProtKB:Q13114	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101835 MGI:MGI:107548 MGI:MGI:108041 MGI:MGI:108072 PANTHER:PTN000805648 RGD:1306853 RGD:1310457 UniProtKB:Q12933 UniProtKB:Q9Y4K3	C		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108041 PANTHER:PTN002562108 UniProtKB:Q13114	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000805720 UniProtKB:O00463 UniProtKB:Q13114	F		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108041 PANTHER:PTN002562108 UniProtKB:Q13114	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107548 MGI:MGI:108041 PANTHER:PTN000805720	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000805720 UniProtKB:Q13114	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004842	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004842	P		Seeded From UniProt	complete
involved_in	GO:0050688	regulation of defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	C		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
involved_in	GO:0032648	regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
involved_in	GO:0030162	regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	F		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60803 ensembl:ENSMUSP00000021706	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
involved_in	GO:0008063	Toll signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001293 InterPro:IPR012227	F		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012227	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
involved_in	GO:0050688	regulation of defense response to virus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027128 InterPro:IPR037304	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7530216^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10799510^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Reactome:R-HSA-936964 Reactome:R-HSA-9013973	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5676594 Reactome:R-HSA-5668541	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-936941 Reactome:R-HSA-936475 Reactome:R-HSA-936381 Reactome:R-HSA-918232 Reactome:R-HSA-918229 Reactome:R-HSA-918227 Reactome:R-HSA-918225 Reactome:R-HSA-9013992 Reactome:R-HSA-9013990 Reactome:R-HSA-9013986 Reactome:R-HSA-9013985 Reactome:R-HSA-9013979 Reactome:R-HSA-9013978 Reactome:R-HSA-9013974 Reactome:R-HSA-5690843 Reactome:R-HSA-5676598 Reactome:R-HSA-5676597 Reactome:R-HSA-5676596 Reactome:R-HSA-5676595 Reactome:R-HSA-5676593 Reactome:R-HSA-5668543 Reactome:R-HSA-5668534 Reactome:R-HSA-5668481 Reactome:R-HSA-5668454 Reactome:R-HSA-5668417 Reactome:R-HSA-5668414 Reactome:R-HSA-5602624 Reactome:R-HSA-5362500 Reactome:R-HSA-5362486 Reactome:R-HSA-2213017 Reactome:R-HSA-2201338 Reactome:R-HSA-166271 Reactome:R-HSA-166245	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	Reactome:R-HSA-9013974 Reactome:R-HSA-2213017	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, Y et al. (2013) The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 39 111-22 PubMed GONUTS page
↑ Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bista, P et al. (2010) TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J. Biol. Chem. 285 12971-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sato, T et al. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358 113-8 PubMed GONUTS page
↑ Rooney, IA et al. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275 14307-15 PubMed GONUTS page

[PMID:23871208-1] Wang, Y et al. (2013) The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 39 111-22 PubMed GONUTS page

[PMID:11728344-2] Wiley, SR et al. (2001) A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity 15 837-46 PubMed GONUTS page

[PMID:20185819-3] 3.0 ^3.1 ^3.2 Bista, P et al. (2010) TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J. Biol. Chem. 285 12971-8 PubMed GONUTS page

[PMID:11279055-4] 4.0 ^4.1 Zapata, JM et al. (2001) A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J. Biol. Chem. 276 24242-52 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7530216-6] Sato, T et al. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358 113-8 PubMed GONUTS page

[PMID:10799510-7] Rooney, IA et al. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J. Biol. Chem. 275 14307-15 PubMed GONUTS page

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HUMAN:TRAF3

Contents

Annotations

Notes

References

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