MOUSE:TLR3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tlr3
Protein Name(s)	Toll-like receptor 3
External Links
UniProt	Q99MB1
EMBL	AF420279 AF355152 AK083977
CCDS	CCDS22278.1
RefSeq	NP_569054.2 XP_006509341.1 XP_006509342.1 XP_006509343.1 XP_006509344.1 XP_006509345.1 XP_006509346.1
UniGene	Mm.33874
PDB	3CIG 3CIY
PDBsum	3CIG 3CIY
ProteinModelPortal	Q99MB1
SMR	Q99MB1
IntAct	Q99MB1
MINT	MINT-4138015
ChEMBL	CHEMBL2146340
PhosphoSite	Q99MB1
MaxQB	Q99MB1
PaxDb	Q99MB1
PRIDE	Q99MB1
Ensembl	ENSMUST00000034056 ENSMUST00000167106
GeneID	142980
KEGG	mmu:142980
UCSC	uc009loy.1
CTD	7098
MGI	MGI:2156367
eggNOG	NOG265249
GeneTree	ENSGT00760000119006
HOGENOM	HOG000251618
HOVERGEN	HBG023181
InParanoid	Q99MB1
KO	K05401
OMA	MLRRVAC
OrthoDB	EOG79SDZG
PhylomeDB	Q99MB1
TreeFam	TF325595
Reactome	REACT_196636 REACT_198539 REACT_198976 REACT_222971 REACT_225463 REACT_226192
EvolutionaryTrace	Q99MB1
NextBio	370067
PRO	PR:Q99MB1
Proteomes	UP000000589
Bgee	Q99MB1
CleanEx	MM_TLR3
ExpressionAtlas	Q99MB1
Genevestigator	Q99MB1
GO	GO:0009986 GO:0005789 GO:0010008 GO:0016021 GO:0005765 GO:0003725 GO:0004888 GO:0035690 GO:0071360 GO:0035458 GO:0071346 GO:0071260 GO:0006952 GO:0051607 GO:0097191 GO:0007252 GO:0006954 GO:0045087 GO:0008584 GO:0002282 GO:0002756 GO:0097527 GO:0043065 GO:0045080 GO:0043123 GO:0050729 GO:0045356 GO:0045359 GO:0032728 GO:0045078 GO:0032735 GO:0032755 GO:0032757 GO:0046330 GO:0042346 GO:0051092 GO:0001934 GO:0034123 GO:0045944 GO:0032760 GO:0032481 GO:0034346 GO:0043330 GO:0009615 GO:0034138
Gene3D	3.40.50.10140
InterPro	IPR000483 IPR001611 IPR003591 IPR000372 IPR000157 IPR027173
PANTHER	PTHR24365:SF5
Pfam	PF00560 PF13855 PF01582
SMART	SM00369 SM00082 SM00013 SM00255
SUPFAM	SSF52200
PROSITE	PS51450 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:26934179^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001F1DA8_10090	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15356140^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15356140^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:15356140^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:15356140^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:15356140^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	PMID:12054664^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
involved_in	GO:0045356	positive regulation of interferon-alpha biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
involved_in	GO:0045078	positive regulation of interferon-gamma biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15455	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138 RGD:735171	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071360	cellular response to exogenous dsRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:18250457^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2429859	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12855817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690535	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045356	positive regulation of interferon-alpha biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:12855817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045078	positive regulation of interferon-gamma biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043331	response to dsRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043330	response to exogenous dsRNA	PMID:12855817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690535	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043330	response to exogenous dsRNA	PMID:21266579^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16260493^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346877	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12855817^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690535	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:19734906^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16260493^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034346	positive regulation of type III interferon production	PMID:18207576^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034123	positive regulation of toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17008311^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:17008311^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032481	positive regulation of type I interferon production	PMID:18207576^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	PMID:14993594^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007252	I-kappaB phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	PMID:11607032^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653138	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	C		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15455	F		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002730	regulation of dendritic cell cytokine production	PMID:19047410^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735171	P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0043331	response to dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	C		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	F		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LN63 ensembl:ENSRNOP00000070415	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0097527	necroptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0045359	positive regulation of interferon-beta biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0045356	positive regulation of interferon-alpha biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0045078	positive regulation of interferon-gamma biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	F		Seeded From UniProt	complete
involved_in	GO:0034123	positive regulation of toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	C		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15455 ensembl:ENSP00000296795	F		Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0002756	MyD88-independent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	C		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0034138	toll-like receptor 3 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027173	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:15356140^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Pitzler, L et al. (2016) miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction. Stem Cells 34 1297-309 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page
↑ Matsumoto, M et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293 1364-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ank, N et al. (2008) An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J. Immunol. 180 2474-85 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Yamamoto, M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 640-3 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page
↑ Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page
↑ Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page
↑ ^10.0 ^10.1 Iocca, HA et al. (2008) TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. J. Neuroimmunol. 194 97-106 PubMed GONUTS page
↑ ^11.0 ^11.1 Kanneganti, TD et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281 36560-8 PubMed GONUTS page
↑ Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page
↑ Tabeta, K et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 101 3516-21 PubMed GONUTS page
↑ Alexopoulou, L et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 732-8 PubMed GONUTS page
↑ Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

[PMID:26934179-1] Pitzler, L et al. (2016) miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction. Stem Cells 34 1297-309 PubMed GONUTS page

[PMID:15356140-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:12054664-3] Matsumoto, M et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293 1364-9 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18250457-5] Ank, N et al. (2008) An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J. Immunol. 180 2474-85 PubMed GONUTS page

[PMID:12855817-6] 6.0 ^6.1 ^6.2 ^6.3 Yamamoto, M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301 640-3 PubMed GONUTS page

[PMID:16260493-7] 7.0 ^7.1 ^7.2 Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page

[PMID:21266579-8] Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

[PMID:19734906-9] Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page

[PMID:18207576-10] 10.0 ^10.1 Iocca, HA et al. (2008) TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. J. Neuroimmunol. 194 97-106 PubMed GONUTS page

[PMID:17008311-11] 11.0 ^11.1 Kanneganti, TD et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281 36560-8 PubMed GONUTS page

[PMID:18261938-12] Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page

[PMID:14993594-13] Tabeta, K et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 101 3516-21 PubMed GONUTS page

[PMID:11607032-14] Alexopoulou, L et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 732-8 PubMed GONUTS page

[PMID:19047410-15] Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

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