Category:GO:0097191 ! extrinsic apoptotic signaling pathway

name: extrinsic apoptotic signaling pathway
namespace: biological_process
def: "The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
synonym: "death receptor-mediated apoptosis" NARROW []
synonym: "extrinsic apoptosis" NARROW []
synonym: "extrinsic apoptotic pathway" EXACT []
synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW []
synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway

AmiGO <GOterm>GO:0097191</GOterm>
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