name: extrinsic apoptotic signaling pathway
The contents of this box are automatically generated. You can help by adding information to the "Notes"
def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]
comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
synonym: "death receptor-mediated apoptosis" NARROW 
synonym: "extrinsic apoptosis" NARROW 
synonym: "extrinsic apoptotic pathway" EXACT 
synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW 
synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0007166 ! cell surface receptor signaling pathway
is_a: GO:0097190 ! apoptotic signaling pathway
Gene Ontology Home
See Help:References for how to manage references in GONUTS.
This category has the following 10 subcategories, out of 10 total.
Pages in category "GO:0097191 ! extrinsic apoptotic signaling pathway"
The following 61 pages are in this category, out of 61 total.
Jump to pages starting with: C H M P R