HUMAN:IFNG

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IFNG
Protein Name(s)	Interferon gamma IFN-gamma Immune interferon
External Links
UniProt	P01579
EMBL	X13274 J00219 X01992 V00543 AY255837 AF375790 AB451324 AB451453 CH471054 BC070256
CCDS	CCDS8980.1
PIR	A93284
RefSeq	NP_000610.2
UniGene	Hs.856
PDB	1EKU 1FG9 1FYH 1HIG 3BES
PDBsum	1EKU 1FG9 1FYH 1HIG 3BES
ProteinModelPortal	P01579
SMR	P01579
BioGrid	109680
DIP	DIP-483N
IntAct	P01579
MINT	MINT-1508034
STRING	9606.ENSP00000229135
DrugBank	DB01296 DB01250
PhosphoSite	P01579
UniCarbKB	P01579
DMDM	124479
PaxDb	P01579
PRIDE	P01579
DNASU	3458
Ensembl	ENST00000229135
GeneID	3458
KEGG	hsa:3458
UCSC	uc001stw.1
CTD	3458
GeneCards	GC12M068548
HGNC	HGNC:5438
HPA	CAB010344
MIM	147570 609135
neXtProt	NX_P01579
Orphanet	88
PharmGKB	PA29674
eggNOG	NOG45353
GeneTree	ENSGT00390000007831
HOGENOM	HOG000254784
HOVERGEN	HBG056912
InParanoid	P01579
KO	K04687
OMA	KEYFNAS
OrthoDB	EOG7VHSZM
PhylomeDB	P01579
TreeFam	TF336308
Reactome	REACT_24980 REACT_25078
SignaLink	P01579
EvolutionaryTrace	P01579
GeneWiki	Interferon-gamma
GenomeRNAi	3458
NextBio	13624
PMAP-CutDB	P01579
PRO	PR:P01579
Proteomes	UP000005640
Bgee	P01579
CleanEx	HS_IFNG
ExpressionAtlas	P01579
Genevestigator	P01579
GO	GO:0009897 GO:0005576 GO:0005615 GO:0005125 GO:0005133 GO:0002250 GO:0019882 GO:0006915 GO:0002302 GO:0007050 GO:0007166 GO:0006928 GO:0071351 GO:0071222 GO:0019221 GO:0042742 GO:0042832 GO:0051607 GO:0030968 GO:0097191 GO:0006959 GO:0060333 GO:0030857 GO:0044130 GO:0032700 GO:0003340 GO:0072308 GO:0031642 GO:0048662 GO:0000122 GO:0001781 GO:0030593 GO:0060559 GO:0045785 GO:0008284 GO:0045080 GO:0060550 GO:0060552 GO:0050718 GO:0045084 GO:0032735 GO:0032747 GO:0045410 GO:0048304 GO:0051712 GO:0051044 GO:0002053 GO:0045348 GO:0045666 GO:0045429 GO:0045672 GO:0033141 GO:0034393 GO:0032224 GO:0042102 GO:0045944 GO:2000309 GO:0032760 GO:0042511 GO:0060557 GO:0000060 GO:2000345 GO:0050796 GO:0060334 GO:0098908 GO:0002026 GO:0042493 GO:0009615 GO:0050954
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002069
PANTHER	PTHR11419
Pfam	PF00714
PIRSF	PIRSF001936
ProDom	PD002435
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01581	P	regulates_o_occurs_in:(CL:0000540) occurs_in:(UBERON:0002181) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01581	P	occurs_in:(UBERON:0002181) occurs_in:(CL:0000129) positively_regulates:(GO:0004972)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010835	regulation of protein ADP-ribosylation	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:26347139^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	PMID:20209097^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090312	positive regulation of protein deacetylation	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:11487543^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:11487543^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903543	positive regulation of exosomal secretion	PMID:11487543^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23817958^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23817958^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20209097^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00182) occurs_in:(CL:2000001)	Seeded From UniProt	complete
	GO:0008009	chemokine activity	PMID:21962843^[7]	ECO:0000314			F		Figure 2. demonstrates the different levels of the chemokines in the serum of humans with and without aortic aneurysms. It is shown that patients with thoracic aortic aneurysms have elevated levels of interferon gamma.	complete CACAO 2128
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:11698262^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0010634	positive regulation of epithelial cell migration	PMID:11698262^[8]	ECO:0000314			P		Based of figure 7 and figure 8 wound healing of Calu-3 epithelial lung cells is enhanced by Interferon (IFN)-γ (Interferon gamma).	complete CACAO 6416
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:22504299^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	PMID:16220542^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:16942485^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01581	P		Seeded From UniProt	complete
involved_in	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	PMID:9282826^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060557	positive regulation of vitamin D biosynthetic process	PMID:9282826^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process	PMID:9282826^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	PMID:9282826^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051712	positive regulation of killing of cells of other organism	PMID:7544003^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18373975^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:8383325^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:16942485^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:16220542^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:8383325^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:15604419^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034393	positive regulation of smooth muscle cell apoptotic process	PMID:16942485^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:21268089^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032747	positive regulation of interleukin-23 production	PMID:20027291^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	PMID:18501882^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:16942485^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000359)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:20041150^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01581	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01581	P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:7605994^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:8557999^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718 RGD:2866 UniProtKB:P07353 UniProtKB:P49708	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:16280321^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:16280321^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:16280321^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:7828849^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P53355	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:7828849^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51397	P		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:10477596^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	PMID:10477596^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045589	regulation of regulatory T cell differentiation	Reactome:R-HSA-8877330	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-909552 Reactome:R-HSA-9006431 Reactome:R-HSA-9006422 Reactome:R-HSA-877269 Reactome:R-HSA-873927 Reactome:R-HSA-873926 Reactome:R-HSA-873924 Reactome:R-HSA-873922 Reactome:R-HSA-873921 Reactome:R-HSA-873919 Reactome:R-HSA-873918	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Sajish, M et al. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat. Chem. Biol. 8 547-54 PubMed GONUTS page
↑ Kimura, T et al. (2015) TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J. Cell Biol. 210 973-89 PubMed GONUTS page
↑ ^4.0 ^4.1 Mengshol, JA et al. (2010) A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE 5 e9504 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 van Niel, G et al. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121 337-49 PubMed GONUTS page
↑ ^6.0 ^6.1 Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
↑ Gallo, A et al. (2012) Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J. Thorac. Cardiovasc. Surg. 143 704-10 PubMed GONUTS page
↑ ^8.0 ^8.1 Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page
↑ ^9.0 ^9.1 Kotake, S et al. (2005) IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur. J. Immunol. 35 3353-63 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Jia, G et al. (2006) Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis. Immunol. Cell Biol. 84 422-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Besançon, F et al. (1997) HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. J. Interferon Cytokine Res. 17 461-7 PubMed GONUTS page
↑ Vouldoukis, I et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc. Natl. Acad. Sci. U.S.A. 92 7804-8 PubMed GONUTS page
↑ Schramme, A et al. (2008) The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells. Biochem. Biophys. Res. Commun. 370 311-6 PubMed GONUTS page
↑ ^14.0 ^14.1 Corbett, JA et al. (1993) Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc. Natl. Acad. Sci. U.S.A. 90 1731-5 PubMed GONUTS page
↑ Huang, A et al. (2005) Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ. Res. 96 164-71 PubMed GONUTS page
↑ Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page
↑ van de Wetering, D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4 e8396 PubMed GONUTS page
↑ Li, J et al. () Negative regulation of IL-17 production by OX40/OX40L interaction. Cell. Immunol. 253 31-7 PubMed GONUTS page
↑ Feng, J et al. (2009) Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE 4 e8480 PubMed GONUTS page
↑ Hayes, MP et al. (1995) Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 86 646-50 PubMed GONUTS page
↑ Snijders, A et al. (1996) Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156 1207-12 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
↑ ^24.0 ^24.1 Deiss, LP et al. (1995) Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9 15-30 PubMed GONUTS page
↑ ^25.0 ^25.1 Kawai, T et al. (1999) Selective diapedesis of Th1 cells induced by endothelial cell RANTES. J. Immunol. 163 3269-78 PubMed GONUTS page

[PMID:23629966-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page

[PMID:22504299-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Sajish, M et al. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat. Chem. Biol. 8 547-54 PubMed GONUTS page

[PMID:26347139-3] Kimura, T et al. (2015) TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J. Cell Biol. 210 973-89 PubMed GONUTS page

[PMID:20209097-4] 4.0 ^4.1 Mengshol, JA et al. (2010) A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE 5 e9504 PubMed GONUTS page

[PMID:11487543-5] 5.0 ^5.1 ^5.2 van Niel, G et al. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121 337-49 PubMed GONUTS page

[PMID:23817958-6] 6.0 ^6.1 Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page

[PMID:21962843-7] Gallo, A et al. (2012) Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J. Thorac. Cardiovasc. Surg. 143 704-10 PubMed GONUTS page

[PMID:11698262-8] 8.0 ^8.1 Ahdieh, M et al. (2001) Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am. J. Physiol., Cell Physiol. 281 C2029-38 PubMed GONUTS page

[PMID:16220542-9] 9.0 ^9.1 Kotake, S et al. (2005) IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL. Eur. J. Immunol. 35 3353-63 PubMed GONUTS page

[PMID:16942485-10] 10.0 ^10.1 ^10.2 ^10.3 Jia, G et al. (2006) Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis. Immunol. Cell Biol. 84 422-9 PubMed GONUTS page

[PMID:9282826-11] 11.0 ^11.1 ^11.2 ^11.3 Besançon, F et al. (1997) HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase. J. Interferon Cytokine Res. 17 461-7 PubMed GONUTS page

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