PMID:21962843

Citation	Gallo, A, Saad, A, Ali, R, Dardik, A, Tellides, G and Geirsson, A (2012) Circulating interferon-γ-inducible Cys-X-Cys chemokine receptor 3 ligands are elevated in humans with aortic aneurysms and Cys-X-Cys chemokine receptor 3 is necessary for aneurysm formation in mice. J. Thorac. Cardiovasc. Surg. 143:704-10
Abstract	Inflammation is associated with the formation of aortic aneurysm. This study investigates the role of inducible Cys-X-Cys chemokine receptor 3 and its ligands in the pathogenesis of arterial aneurysms.
Links	PubMed Online version:10.1016/j.jtcvs.2011.08.036
Keywords	Aged; Aged, 80 and over; Analysis of Variance; Aneurysm/chemically induced; Aneurysm/genetics; Aneurysm/immunology; Aneurysm/metabolism; Aneurysm/prevention & control; Animals; Aortic Aneurysm, Thoracic/blood; Aortic Aneurysm, Thoracic/immunology; Aortic Aneurysm, Thoracic/pathology; Biological Markers/blood; Calcium Chloride; Carotid Artery Diseases/chemically induced; Carotid Artery Diseases/genetics; Carotid Artery Diseases/immunology; Carotid Artery Diseases/metabolism; Carotid Artery Diseases/prevention & control; Case-Control Studies; Chemokine CXCL10/blood; Chemokine CXCL11/blood; Chemokine CXCL9/blood; Chi-Square Distribution; Connecticut; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interferon-gamma/blood; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Receptors, CXCR3/blood; Receptors, CXCR3/deficiency; Receptors, CXCR3/genetics; Receptors, CXCR3/metabolism; Up-Regulation
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:IFNG		GO:0008009: chemokine activity	ECO:0000314:		F		Figure 2. demonstrates the different levels of the chemokines in the serum of humans with and without aortic aneurysms. It is shown that patients with thoracic aortic aneurysms have elevated levels of interferon gamma.	complete CACAO 2128

References

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