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MOUSE:GSK3A
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Gsk3a | |
| Protein Name(s) | Glycogen synthase kinase-3 alpha
GSK-3 alpha Serine/threonine-protein kinase GSK3A | |
| External Links | ||
| UniProt | Q2NL51 | |
| EMBL | AC156992 BC111032 | |
| CCDS | CCDS20976.1 | |
| RefSeq | NP_001026837.1 | |
| UniGene | Mm.491101 | |
| ProteinModelPortal | Q2NL51 | |
| SMR | Q2NL51 | |
| BioGrid | 546781 | |
| IntAct | Q2NL51 | |
| STRING | 10090.ENSMUSP00000071654 | |
| ChEMBL | CHEMBL2176843 | |
| PhosphoSite | Q2NL51 | |
| MaxQB | Q2NL51 | |
| PaxDb | Q2NL51 | |
| PRIDE | Q2NL51 | |
| Ensembl | ENSMUST00000071739 | |
| GeneID | 606496 | |
| KEGG | mmu:606496 | |
| UCSC | uc009frx.1 | |
| CTD | 2931 | |
| MGI | MGI:2152453 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00520000055635 | |
| HOGENOM | HOG000233017 | |
| HOVERGEN | HBG014652 | |
| InParanoid | Q2NL51 | |
| KO | K08822 | |
| OMA | FDELRCP | |
| OrthoDB | EOG7TF78V | |
| PhylomeDB | Q2NL51 | |
| TreeFam | TF101104 | |
| Reactome | REACT_106572 REACT_196588 REACT_220918 | |
| NextBio | 414454 | |
| PMAP-CutDB | Q2NL51 | |
| PRO | PR:Q2NL51 | |
| Proteomes | UP000000589 | |
| Bgee | Q2NL51 | |
| CleanEx | MM_GSK3A | |
| ExpressionAtlas | Q2NL51 | |
| Genevestigator | Q2NL51 | |
| GO | GO:0005524 GO:0004672 GO:0004674 GO:0050321 GO:0003214 GO:0016477 GO:0036016 GO:0071285 GO:0071407 GO:0097192 GO:0005977 GO:0044027 GO:0008286 GO:0061052 GO:0032007 GO:0007399 GO:0071879 GO:0030819 GO:2000467 GO:0045823 GO:1901030 GO:0033138 GO:0010800 GO:0045944 GO:0043161 GO:0006468 GO:0006349 GO:0003073 GO:0016055 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000314 |
P |
Figure 6 |
complete | |||||
| GO:0032872 |
regulation of stress-activated MAPK cascade |
ECO:0000314 |
P |
Figure 3. The MAP kinases are regulated by GSK3β inhibition |
complete | |||||
| GO:0032873 |
negative regulation of stress-activated MAPK cascade |
ECO:0000314 |
P |
Figure 3. The MAP kinases are regulated by GSK3β inhibition. |
complete | |||||
| GO:0034142 |
toll-like receptor 4 signaling pathway |
ECO:0000314 |
P |
Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR. |
complete | |||||
| GO:0034144 |
negative regulation of toll-like receptor 4 signaling pathway |
ECO:0000314 |
P |
Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR. |
complete | |||||
|
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
regulates_expression_of:(ENSEMBL:ENSMUSG00000024431) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
part_of:(GO:0071549) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_input:(UniProtKB:Q8VI36) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000467 |
positive regulation of glycogen (starch) synthase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071879 |
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061052 |
negative regulation of cell growth involved in cardiac muscle cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045823 |
positive regulation of heart contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044027 |
hypermethylation of CpG island |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0106071 |
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006349 |
regulation of gene expression by genetic imprinting |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003214 |
cardiac left ventricle morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003073 |
regulation of systemic arterial blood pressure |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901030 |
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036016 |
cellular response to interleukin-3 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000171 |
negative regulation of dendrite development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904227 |
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903955 |
positive regulation of protein targeting to mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903146 |
regulation of autophagy of mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902004 |
positive regulation of amyloid-beta formation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071285 |
cellular response to lithium ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046325 |
negative regulation of glucose import |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034236 |
protein kinase A catalytic subunit binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034236 |
protein kinase A catalytic subunit binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_has_input:(MGI:MGI:1347521)|regulates_o_has_input:(MGI:MGI:108100) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031398 |
positive regulation of protein ubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0018107 |
peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016477 |
cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98958 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007568 |
aging |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005874 |
microtubule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(MGI:MGI:1347521) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620351 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:1901030 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000171 |
negative regulation of dendrite development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0034236 |
protein kinase A catalytic subunit binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005874 |
microtubule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P18265 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050321 |
tau-protein kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005977 |
glycogen metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009968 |
negative regulation of signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Chen, L et al. (2012) Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis. PLoS ONE 7 e45202 PubMed GONUTS page
- ↑ 2.0 2.1 Lin, SY et al. (2012) GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336 477-81 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page
- ↑ Cai, X et al. (2006) Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol. Cell. Biol. 26 2857-68 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Zhou, J et al. (2010) GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J. Clin. Invest. 120 2280-91 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Popkie, AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285 41337-47 PubMed GONUTS page
- ↑ Waraich, RS et al. (2008) Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J. Biol. Chem. 283 11226-33 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Maurer, U et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 749-60 PubMed GONUTS page
- ↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page
- ↑ Vertino, AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol. Biol. Cell 16 2039-48 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Yamamoto, H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12 1215-23 PubMed GONUTS page
- ↑ 12.0 12.1 Song, J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5 150-8 PubMed GONUTS page
c
- GO:0005975 ! carbohydrate metabolic process
- GO:0003214 ! cardiac left ventricle morphogenesis
- GO:0071285 ! cellular response to lithium ion
- GO:0032869 ! cellular response to insulin stimulus
- GO:0071549 ! cellular response to dexamethasone stimulus
- GO:0036016 ! cellular response to interleukin-3
- GO:0016477 ! cell migration
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
e
i
m
n
- GO:1904227 ! negative regulation of glycogen synthase activity, transferring glucose-1-phosphate
- GO:0046325 ! negative regulation of D-glucose import
- GO:0061052 ! negative regulation of cell growth involved in cardiac muscle cell development
- GO:0032007 ! negative regulation of TOR signaling
- GO:0044027 ! negative regulation of gene expression via chromosomal CpG island methylation
- GO:0034144 ! negative regulation of toll-like receptor 4 signaling pathway
- GO:0009968 ! negative regulation of signal transduction
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:2000171 ! negative regulation of dendrite development
- GO:0032873 ! negative regulation of stress-activated MAPK cascade
- GO:0007399 ! nervous system development
- GO:0000166 ! nucleotide binding
o
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0018107 ! peptidyl-threonine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0045823 ! positive regulation of heart contraction
- GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
- GO:1903955 ! positive regulation of protein targeting to mitochondrion
- GO:0106071 ! positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0010800 ! positive regulation of peptidyl-threonine phosphorylation
- GO:2000467 ! positive regulation of glycogen (starch) synthase activity
- GO:1901030 ! positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- GO:0010628 ! positive regulation of gene expression
- GO:0031398 ! positive regulation of protein ubiquitination
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0010508 ! positive regulation of autophagy
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0043525 ! positive regulation of neuron apoptotic process
- GO:1902004 ! positive regulation of amyloid-beta formation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0004672 ! protein kinase activity
- GO:0034236 ! protein kinase A catalytic subunit binding
- GO:0019901 ! protein kinase binding
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
t
