PMID:23028846

Citation	Chen, L, Ren, F, Zhang, H, Wen, T, Piao, Z, Zhou, L, Zheng, S, Zhang, J, Chen, Y, Han, Y, Duan, Z and Ma, Y (2012) Inhibition of Glycogen Synthase Kinase 3β Ameliorates D-GalN/LPS-Induced Liver Injury by Reducing Endoplasmic Reticulum Stress-Triggered Apoptosis. PLoS ONE 7:e45202
Abstract	Glycogen synthase kinase 3β(GSK3β) is a ubiquitous serine-threonine protein kinase that participates in numerous cellular processes and disease pathophysiology. We aimed to determine therapeutic potential of GSK3β inhibition and its mechanism in a well-characterized model of lipopolysaccharide (LPS)-induced model of acute liver failure (ALF).
Links	PubMed PMC3461002 Online version:10.1371/journal.pone.0045202
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:GSK3B	involved_in	GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:GSK3B		GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ECO:0000314:		P		Figure 6	complete CACAO 6111
MOUSE:GSK3B		GO:0032872: regulation of stress-activated MAPK cascade	ECO:0000314:		P		Figure 3. The MAP kinases are regulated by GSK3β inhibition.	complete CACAO 6135
MOUSE:GSK3B		GO:0032873: negative regulation of stress-activated MAPK cascade	ECO:0000314:		P		Figure 3. The MAP kinases are regulated by GSK3β inhibition.	complete CACAO 6136
MOUSE:GSK3B		GO:0034143: regulation of toll-like receptor 4 signaling pathway	ECO:0000314:		P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6139
MOUSE:GSK3B		GO:0034144: negative regulation of toll-like receptor 4 signaling pathway	ECO:0000314:		P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6140
MOUSE:GSK3A		GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ECO:0000314:		P		Figure 6	complete CACAO 6113
MOUSE:GSK3A		GO:0032872: regulation of stress-activated MAPK cascade	ECO:0000314:		P		Figure 3. The MAP kinases are regulated by GSK3β inhibition	complete CACAO 6137
MOUSE:GSK3A		GO:0032873: negative regulation of stress-activated MAPK cascade	ECO:0000314:		P		Figure 3. The MAP kinases are regulated by GSK3β inhibition.	complete CACAO 6138
MOUSE:GSK3A		GO:0034142: toll-like receptor 4 signaling pathway	ECO:0000314:		P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6142
MOUSE:GSK3A		GO:0034144: negative regulation of toll-like receptor 4 signaling pathway	ECO:0000314:		P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6143

References

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