MOUSE:GSK3B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gsk3b
Protein Name(s)	Glycogen synthase kinase-3 beta GSK-3 beta Serine/threonine-protein kinase GSK3B
External Links
UniProt	Q9WV60
EMBL	AF156099 BC006936 BC060743
CCDS	CCDS28163.1
RefSeq	NP_062801.1
UniGene	Mm.394930
PDB	4NU1
PDBsum	4NU1
ProteinModelPortal	Q9WV60
SMR	Q9WV60
BioGrid	208115
IntAct	Q9WV60
MINT	MINT-4096935
STRING	10090.ENSMUSP00000110398
BindingDB	Q9WV60
ChEMBL	CHEMBL1075321
PhosphoSite	Q9WV60
MaxQB	Q9WV60
PaxDb	Q9WV60
PRIDE	Q9WV60
Ensembl	ENSMUST00000023507
GeneID	56637
KEGG	mmu:56637
UCSC	uc007zen.1
CTD	2932
MGI	MGI:1861437
eggNOG	COG0515
GeneTree	ENSGT00520000055635
HOGENOM	HOG000233017
HOVERGEN	HBG014652
InParanoid	Q9WV60
KO	K03083
OrthoDB	EOG7TF78V
PhylomeDB	Q9WV60
TreeFam	TF101104
Reactome	REACT_196588 REACT_203336 REACT_216784 REACT_218396 REACT_220918 REACT_222185 REACT_230286 REACT_234076 REACT_244852 REACT_248000 REACT_250714 REACT_252458 REACT_258576 REACT_260752 REACT_261276 REACT_263467 REACT_268522 REACT_270923
ChiTaRS	Gsk3b
NextBio	313081
PMAP-CutDB	Q9WV60
PRO	PR:Q9WV60
Proteomes	UP000000589
Bgee	Q9WV60
CleanEx	MM_GSK3B
ExpressionAtlas	Q9WV60
Genevestigator	Q9WV60
GO	GO:0030877 GO:0044297 GO:0005813 GO:0005737 GO:0005829 GO:0043198 GO:0043197 GO:0030426 GO:0016020 GO:0045121 GO:0043227 GO:0043025 GO:0097481 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0030529 GO:0005524 GO:0008013 GO:0016301 GO:0004672 GO:0004674 GO:0050321 GO:0007409 GO:0060070 GO:0044337 GO:0016477 GO:0008283 GO:0036016 GO:0071260 GO:0007623 GO:0007010 GO:0001837 GO:0006983 GO:0030010 GO:0097192 GO:0045444 GO:0005977 GO:0021766 GO:0044027 GO:0035556 GO:0007520 GO:0014902 GO:0043066 GO:0010614 GO:0050774 GO:0043407 GO:0014043 GO:0010977 GO:0051534 GO:0032091 GO:0031333 GO:0009887 GO:0018105 GO:0016310 GO:0045773 GO:0001954 GO:1901030 GO:0033138 GO:0010800 GO:0032436 GO:0032092 GO:0031334 GO:0046827 GO:0032855 GO:2000738 GO:0045944 GO:0006611 GO:0035372 GO:0006468 GO:0000320 GO:0006349 GO:0032886 GO:0010975 GO:0048168 GO:0042493 GO:0010226 GO:0071109 GO:0016055
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004696	glycogen synthase kinase 3 activity	PMID:20056751^[1]	ECO:0000315			F		Figure 2-GSK3β gene deletion reduced urine osmolality after water deprivation. Urine osmolality values of urine collected during 18 hours of water deprivation.	complete CACAO 5839
	Q9WV60		PMID:PMC2831860	ECO:0000315					Figure 3- GSKB gene deletion reduced renal AQP2 levels	Missing: Valid GO ID CACAO 5843
	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	PMID:20056751^[1]	ECO:0000315			P		Figure 2-GSK3β gene deletion reduced urine osmolality after water deprivation. Urine osmolality values of urine collected during 18 hours of water deprivation.	complete CACAO 6104
	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:23028846^[2]	ECO:0000314			P		Figure 6	complete CACAO 6111
	GO:0032872	regulation of stress-activated MAPK cascade	PMID:23028846^[2]	ECO:0000314			P		Figure 3. The MAP kinases are regulated by GSK3β inhibition.	complete CACAO 6135
	GO:0032873	negative regulation of stress-activated MAPK cascade	PMID:23028846^[2]	ECO:0000314			P		Figure 3. The MAP kinases are regulated by GSK3β inhibition.	complete CACAO 6136
	GO:0004674	protein serine/threonine kinase activity	PMID:25331900^[3]	ECO:0000314			F		Fig. 3 GSK3B activity altered by p25, which correlates with loss of phosphorylation at serine 9	complete CACAO 10345
	GO:0034143	regulation of toll-like receptor 4 signaling pathway	PMID:23028846^[2]	ECO:0000314			P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6139
	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	PMID:23028846^[2]	ECO:0000314			P		Figure 4B and 4C. The inhibition of GSK3β decreased the expression of TLR4 mRNA and TLR4 proteins at 3 hours detected by qRT-PCR.	complete CACAO 6140
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:28556462^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:28556462^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:12154096^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:22539723^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22539723^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20371704^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q2NL51	P	regulates_expression_of:(ENSEMBL:ENSMUSG00000024431)	Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:20371704^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q2NL51	P	part_of:(GO:0071549)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:26160071^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10090	P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24974728^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002249) regulates_expression_of:(ENSEMBL:ENSMUSG00000040752) part_of:(GO:0055007)\|occurs_in(CL:0002249) regulates_expression_of:(ENSEMBL:ENSMUSG00000026414) part_of:(GO:0055007)	Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	PMID:24974728^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16537926^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q2NL51	P	has_input:(UniProtKB:Q8VI36)	Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:28057765^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8C0M8	F		Seeded From UniProt	complete
involved_in	GO:1904780	negative regulation of protein localization to centrosome	PMID:28057765^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0011108) has_regulation_target:(UniProtKB:Q8C0M8)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:28057765^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0011108)	Seeded From UniProt	complete
part_of	GO:1990909	Wnt signalosome	PMID:22899650^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22899650^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5S006	F	occurs_in:(GO:0005737) occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:23028846^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:20890042^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21047779^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12154096^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0042981)	Seeded From UniProt	complete
involved_in	GO:0044027	hypermethylation of CpG island	PMID:21047779^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	PMID:21047779^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	PMID:16543145^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:16543145^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0036016	cellular response to interleukin-3	PMID:16543145^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032886	regulation of microtubule-based process	PMID:21295697^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:20123978^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:17182001^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18266	C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:20123978^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16543145^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16543145^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:20123978^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22057101^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:26160071^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS0000554A4F_10090	P	occurs_in:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20111716^[20]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:20111716^[20]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:17986005^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:1347521)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:17986005^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:23074275^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2673967 MGI:MGI:94941	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014902	myotube differentiation	PMID:15282335^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98573	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17114649^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014043	negative regulation of neuron maturation	PMID:23015435^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102539 MGI:MGI:1934030 MGI:MGI:97321	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:23015435^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102539 MGI:MGI:1934030 MGI:MGI:97321	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	PMID:23015435^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	PMID:24227739^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010918	positive regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:17986005^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:11782539^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010043	response to zinc ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:10894547^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888887	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:12874278^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007520	myoblast fusion	PMID:15282335^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98573	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007520	myoblast fusion	PMID:15282335^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:18716223^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007163	establishment or maintenance of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006983	ER overload response	PMID:14744935^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006983	ER overload response	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006611	protein export from nucleus	PMID:11782539^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17331) occurs_in:(CL:0002131) has_participant:(MGI:MGI:102469)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:19141611^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1919364	P	has_participant:(MGI:MGI:88276)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17026964^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:14730361^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12432063^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0005977	glycogen metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12502791^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22064483^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12502791^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24623780^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0002608) has_direct_input:(MGI:MGI:106658)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22660580^[40]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:98427)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17986005^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1347521)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10894547^[28]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
enables	GO:0004672	protein kinase activity	PMID:14730361^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	PMID:18824542^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000320	re-entry into mitotic cell cycle	PMID:12502791^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001223	negative regulation of neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000738	positive regulation of stem cell differentiation	PMID:22064483^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000171	negative regulation of dendrite development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:21709260^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904781	positive regulation of protein localization to centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904339	negative regulation of dopaminergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901984	negative regulation of protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900181	negative regulation of protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0106027	neuron projection organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099159	regulation of modification of postsynaptic structure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090290	positive regulation of osteoclast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071109	superior temporal gyrus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061049	cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:16815997^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108559	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:15282335^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051001	negative regulation of nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050774	negative regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:15192701^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046827	positive regulation of protein export from nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23015435^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540) regulates_o_occurs_in:(CL:0000540) has_regulation_target:(MGI:MGI:1934030) has_regulation_target:(MGI:MGI:102539)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	PMID:24623780^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106658 MGI:MGI:98927	P	occurs_in:(CL:0002608) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045667	regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:12502791^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:23015435^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043547	positive regulation of GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:0043227	membrane-bounded organelle	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:10894547^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888887	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035733	hepatic stellate cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21072211^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	PMID:14749367^[46]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035372	protein localization to microtubule	PMID:18716223^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94941	P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	F		Seeded From UniProt	complete
enables	GO:0034452	dynactin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034392	negative regulation of smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
enables	GO:0034236	protein kinase A catalytic subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033690	positive regulation of osteoblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:17986005^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:1347521)\|regulates_o_has_input:(MGI:MGI:108100)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032886	regulation of microtubule-based process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:22660580^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924375 MGI:MGI:3039600	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	PMID:19141611^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031333	negative regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:10318824^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	C		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030516	regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:12805290^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030011	maintenance of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030010	establishment of cell polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70982	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR033573	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:22057101^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-209144 Reactome:R-NUL-209060	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9008717 Reactome:R-MMU-9008715 Reactome:R-MMU-9008677 Reactome:R-MMU-182564	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-NUL-209144 Reactome:R-NUL-209060 Reactome:R-MMU-182564	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Rao, R et al. (2010) GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. J. Am. Soc. Nephrol. 21 428-37 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chen, L et al. (2012) Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis. PLoS ONE 7 e45202 PubMed GONUTS page
↑ Chow, HM et al. (2014) CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc. Natl. Acad. Sci. U.S.A. 111 E4887-95 PubMed GONUTS page
↑ ^4.0 ^4.1 Besing, RC et al. (2017) GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus 27 890-898 PubMed GONUTS page
↑ ^5.0 ^5.1 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page
↑ ^6.0 ^6.1 Lin, SY et al. (2012) GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336 477-81 PubMed GONUTS page
↑ ^7.0 ^7.1 Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page
↑ ^8.0 ^8.1 Li, Z et al. (2017) miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 24 1205-1213 PubMed GONUTS page
↑ ^9.0 ^9.1 Zhao, J et al. (2014) β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J. Cell. Mol. Med. 18 1562-70 PubMed GONUTS page
↑ Cai, X et al. (2006) Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol. Cell. Biol. 26 2857-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gao, FJ et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol. Biol. Cell 28 587-599 PubMed GONUTS page
↑ ^12.0 ^12.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page
↑ Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Popkie, AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285 41337-47 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Maurer, U et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 749-60 PubMed GONUTS page
↑ Wu, X et al. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell 144 341-52 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Kurabayashi, N et al. (2010) DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol. Cell. Biol. 30 1757-68 PubMed GONUTS page
↑ Takenaka, K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem. Biophys. Res. Commun. 353 501-8 PubMed GONUTS page
↑ ^19.0 ^19.1 Wakatsuki, S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat. Cell Biol. 13 1415-23 PubMed GONUTS page
↑ ^20.0 ^20.1 Perez-Costas, E et al. (2010) Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS ONE 5 e8911 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Yamamoto, H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12 1215-23 PubMed GONUTS page
↑ Walf-Vorderwülbecke, V et al. (2012) Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood 120 4819-28 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Rochat, A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol. Biol. Cell 15 4544-55 PubMed GONUTS page
↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Chen, M et al. (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J. Neurosci. 32 13439-53 PubMed GONUTS page
↑ Marques, JM et al. (2013) CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation. J. Neurosci. 33 18298-310 PubMed GONUTS page
↑ ^27.0 ^27.1 Antos, CL et al. (2002) Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. U.S.A. 99 907-12 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Hoeflich, KP et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406 86-90 PubMed GONUTS page
↑ Kanamori, M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 38758-64 PubMed GONUTS page
↑ ^30.0 ^30.1 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page
↑ Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page
↑ ^32.0 ^32.1 Chen, T et al. (2009) Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J. Biol. Chem. 284 6683-9 PubMed GONUTS page
↑ Yeh, TY et al. (2006) Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem. Biophys. Res. Commun. 350 574-9 PubMed GONUTS page
↑ ^34.0 ^34.1 Song, J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5 150-8 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Pigino, G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 23 4499-508 PubMed GONUTS page
↑ Bek, S & Kemler, R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J. Cell. Sci. 115 4743-53 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 Tang, QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 44-9 PubMed GONUTS page
↑ ^38.0 ^38.1 Bechard, M et al. (2012) Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol. Cell. Biol. 32 288-96 PubMed GONUTS page
↑ ^39.0 ^39.1 Li, CL et al. (2014) SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J. Neurosci. 34 4027-42 PubMed GONUTS page
↑ ^40.0 ^40.1 Zhao, J et al. (2012) F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat. Immunol. 13 651-8 PubMed GONUTS page
↑ Liu, R et al. (2008) Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms. Mol. Cell. Biol. 28 7236-44 PubMed GONUTS page
↑ Sharma, S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108 11381-6 PubMed GONUTS page
↑ Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page
↑ Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page
↑ Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page
↑ Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page
↑ Sakanaka, C & Williams, LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J. Biol. Chem. 274 14090-3 PubMed GONUTS page

[PMID:20056751-1] 1.0 ^1.1 Rao, R et al. (2010) GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity. J. Am. Soc. Nephrol. 21 428-37 PubMed GONUTS page

[PMID:23028846-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chen, L et al. (2012) Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis. PLoS ONE 7 e45202 PubMed GONUTS page

[PMID:25331900-3] Chow, HM et al. (2014) CDK5 activator protein p25 preferentially binds and activates GSK3β. Proc. Natl. Acad. Sci. U.S.A. 111 E4887-95 PubMed GONUTS page

[PMID:28556462-4] 4.0 ^4.1 Besing, RC et al. (2017) GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus 27 890-898 PubMed GONUTS page

[PMID:12154096-5] 5.0 ^5.1 Longo, KA et al. (2002) Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J. Biol. Chem. 277 38239-44 PubMed GONUTS page

[PMID:22539723-6] 6.0 ^6.1 Lin, SY et al. (2012) GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336 477-81 PubMed GONUTS page

[PMID:20371704-7] 7.0 ^7.1 Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page

[PMID:26160071-8] 8.0 ^8.1 Li, Z et al. (2017) miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 24 1205-1213 PubMed GONUTS page

[PMID:24974728-9] 9.0 ^9.1 Zhao, J et al. (2014) β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J. Cell. Mol. Med. 18 1562-70 PubMed GONUTS page

[PMID:16537926-10] Cai, X et al. (2006) Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol. Cell. Biol. 26 2857-68 PubMed GONUTS page

[PMID:28057765-11] 11.0 ^11.1 ^11.2 Gao, FJ et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol. Biol. Cell 28 587-599 PubMed GONUTS page

[PMID:22899650-12] 12.0 ^12.1 Berwick, DC & Harvey, K (2012) LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21 4966-79 PubMed GONUTS page

[PMID:20890042-13] Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page

[PMID:21047779-14] 14.0 ^14.1 ^14.2 Popkie, AP et al. (2010) Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J. Biol. Chem. 285 41337-47 PubMed GONUTS page

[PMID:16543145-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Maurer, U et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 749-60 PubMed GONUTS page

[PMID:21295697-16] Wu, X et al. (2011) Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β. Cell 144 341-52 PubMed GONUTS page

[PMID:20123978-17] 17.0 ^17.1 ^17.2 Kurabayashi, N et al. (2010) DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol. Cell. Biol. 30 1757-68 PubMed GONUTS page

[PMID:17182001-18] Takenaka, K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem. Biophys. Res. Commun. 353 501-8 PubMed GONUTS page

[PMID:22057101-19] 19.0 ^19.1 Wakatsuki, S et al. (2011) ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat. Cell Biol. 13 1415-23 PubMed GONUTS page

[PMID:20111716-20] 20.0 ^20.1 Perez-Costas, E et al. (2010) Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS ONE 5 e8911 PubMed GONUTS page

[PMID:17986005-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Yamamoto, H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12 1215-23 PubMed GONUTS page

[PMID:23074275-22] Walf-Vorderwülbecke, V et al. (2012) Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood 120 4819-28 PubMed GONUTS page

[PMID:15282335-23] 23.0 ^23.1 ^23.2 ^23.3 Rochat, A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol. Biol. Cell 15 4544-55 PubMed GONUTS page

[PMID:17114649-24] Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page

[PMID:23015435-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 Chen, M et al. (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J. Neurosci. 32 13439-53 PubMed GONUTS page

[PMID:24227739-26] Marques, JM et al. (2013) CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation. J. Neurosci. 33 18298-310 PubMed GONUTS page

[PMID:11782539-27] 27.0 ^27.1 Antos, CL et al. (2002) Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. U.S.A. 99 907-12 PubMed GONUTS page

[PMID:10894547-28] 28.0 ^28.1 ^28.2 Hoeflich, KP et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406 86-90 PubMed GONUTS page

[PMID:12874278-29] Kanamori, M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J. Biol. Chem. 278 38758-64 PubMed GONUTS page

[PMID:18716223-30] 30.0 ^30.1 Purro, SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J. Neurosci. 28 8644-54 PubMed GONUTS page

[PMID:14744935-31] Qu, L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev. 18 261-77 PubMed GONUTS page

[PMID:19141611-32] 32.0 ^32.1 Chen, T et al. (2009) Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J. Biol. Chem. 284 6683-9 PubMed GONUTS page

[PMID:17026964-33] Yeh, TY et al. (2006) Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3. Biochem. Biophys. Res. Commun. 350 574-9 PubMed GONUTS page

[PMID:14730361-34] 34.0 ^34.1 Song, J et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5 150-8 PubMed GONUTS page

[PMID:12805290-35] 35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Pigino, G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 23 4499-508 PubMed GONUTS page

[PMID:12432063-36] Bek, S & Kemler, R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J. Cell. Sci. 115 4743-53 PubMed GONUTS page

[PMID:12502791-37] 37.0 ^37.1 ^37.2 ^37.3 Tang, QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 44-9 PubMed GONUTS page

[PMID:22064483-38] 38.0 ^38.1 Bechard, M et al. (2012) Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells. Mol. Cell. Biol. 32 288-96 PubMed GONUTS page

[PMID:24623780-39] 39.0 ^39.1 Li, CL et al. (2014) SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J. Neurosci. 34 4027-42 PubMed GONUTS page

[PMID:22660580-40] 40.0 ^40.1 Zhao, J et al. (2012) F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat. Immunol. 13 651-8 PubMed GONUTS page

[PMID:18824542-41] Liu, R et al. (2008) Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms. Mol. Cell. Biol. 28 7236-44 PubMed GONUTS page

[PMID:21709260-42] Sharma, S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108 11381-6 PubMed GONUTS page

[PMID:16815997-43] Chen, HJ et al. (2006) The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 20 1933-45 PubMed GONUTS page

[PMID:15192701-44] Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page

[PMID:21072211-45] Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page

[PMID:14749367-46] Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page

[PMID:10318824-47] Sakanaka, C & Williams, LT (1999) Functional domains of axin. Importance of the C terminus as an oligomerization domain. J. Biol. Chem. 274 14090-3 PubMed GONUTS page

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MOUSE:GSK3B

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