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Category:GO:0060070 ! canonical Wnt signaling pathway

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DAG for GO:0060070id: GO:0060070

name: canonical Wnt signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling]
synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling]
synonym: "frizzled-1 receptor signaling pathway" NARROW []
synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal]
synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT []
synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT []
is_a: GO:0016055 ! Wnt signaling pathway

AmiGO <GOterm>GO:0060070</GOterm>
Gene Ontology Home


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