MOUSE:MED12

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Med12 (synonyms: Kiaa0192, Mopa, Tnrc11, Trap230)
Protein Name(s)	Mediator of RNA polymerase II transcription subunit 12 Mediator complex subunit 12 OPA-containing protein Thyroid hormone receptor-associated protein complex 230 kDa component Trap230 Trinucleotide repeat-containing gene 11 protein
External Links
UniProt	A2AGH6
EMBL	AL683892 AL683892 BC057085 BC057119 AF071310 AK220216
CCDS	CCDS41078.1
RefSeq	NP_067496.2
UniGene	Mm.20873 Mm.490933
ProteinModelPortal	A2AGH6
BioGrid	208491
CORUM	A2AGH6
DIP	DIP-59233N
IntAct	A2AGH6
MINT	MINT-4105605
STRING	10090.ENSMUSP00000085260
iPTMnet	A2AGH6
PhosphoSitePlus	A2AGH6
MaxQB	A2AGH6
PaxDb	A2AGH6
PeptideAtlas	A2AGH6
PRIDE	A2AGH6
Ensembl	ENSMUST00000087948 ENSMUST00000087956
GeneID	59024
KEGG	mmu:59024
UCSC	uc009txe.1 uc009txf.1
CTD	9968
MGI	MGI:1926212
eggNOG	KOG3598 ENOG410XP2V
GeneTree	ENSGT00440000037505
HOGENOM	HOG000231423
HOVERGEN	HBG052447
InParanoid	A2AGH6
KO	K15162
OMA	MAQVFEG
OrthoDB	EOG091G00I6
TreeFam	TF324178
Reactome	[www.reactome.org/content/detail/R-MMU-212436 R-MMU-212436] [www.reactome.org/content/detail/R-MMU-381340 R-MMU-381340] [www.reactome.org/content/detail/R-MMU-442533 R-MMU-442533]
ChiTaRS	Med12
PRO	PR:A2AGH6
Proteomes	UP000000589
Bgee	ENSMUSG00000079487
ExpressionAtlas	A2AGH6
Genevisible	A2AGH6
GO	GO:0016592 GO:0016020 GO:0005654 GO:0005634 GO:0000151 GO:0008013 GO:0003682 GO:0008022 GO:0019904 GO:0004872 GO:0000980 GO:0001105 GO:0001104 GO:0046966 GO:0003713 GO:0003712 GO:0008134 GO:0001190 GO:0061630 GO:0030521 GO:0090245 GO:0060070 GO:1990403 GO:0048702 GO:0048568 GO:0007492 GO:0007507 GO:0030518 GO:0030178 GO:0001843 GO:0021915 GO:0014003 GO:0045944 GO:0045893 GO:0036342 GO:0014044 GO:0001756 GO:0021510 GO:0019827 GO:0006367 GO:0060071
InterPro	IPR019035 IPR021989 IPR021990
Pfam	PF09497 PF12145 PF12144
SMART	SM01281

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016592	mediator complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001324 MGI:MGI:1926212 PANTHER:PTN000980589 UniProtKB:Q93074	C		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001324 PANTHER:PTN000980589	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000980589 UniProtKB:Q93074 WB:WBGene00001081	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000980589 UniProtKB:Q93074	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990403	embryonic brain development	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090245	axis elongation involved in somitogenesis	PMID:20630950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839484	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
contributes_to	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1585896	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:20630950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839486	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060070	canonical Wnt signaling pathway	PMID:20630950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839486	P	occurs_in:(EMAPA:16756)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048702	embryonic neurocranium morphogenesis	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036342	post-anal tail morphogenesis	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021510	spinal cord development	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	PMID:15340084^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1585896	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014044	Schwann cell development	PMID:23575864^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014003	oligodendrocyte development	PMID:23575864^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839485	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:23575864^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04888	F	occurs_in:(EMAPA:18577) occurs_in:(CL:0000257)\|occurs_in:(EMAPA:18577) occurs_in:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:20630950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839484	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839486	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006367	transcription initiation from RNA polymerase II promoter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:23575864^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98358	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93074	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20720539^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002322) has_participant:(MGI:MGI:101893)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:101893)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:1919200)\|occurs_in(CL:0002322) has_participant:(MGI:MGI:1919200)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:20630950^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839484	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:20589884^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4839486	P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:23575864^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95296)	Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1585896	C		Seeded From UniProt	complete
enables	GO:0046966	thyroid hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	F		Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	C		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	F		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q93074 ensembl:ENSP00000363193	F		Seeded From UniProt	complete
enables	GO:0061630	ubiquitin protein ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A096MKF8 ensembl:ENSRNOP00000068498	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A096MKF8 ensembl:ENSRNOP00000068498	P		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A096MKF8 ensembl:ENSRNOP00000068498	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019035	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019035	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021989	F		Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019035 InterPro:IPR021989	C		Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	PMID:20508642^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-556760	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Rocha, PP et al. (2010) Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis. Birth Defects Res. Part A Clin. Mol. Teratol. 88 626-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Rocha, PP et al. (2010) Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137 2723-31 PubMed GONUTS page
↑ ^4.0 ^4.1 Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page
↑ Malik, S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol. Cell. Biol. 24 8244-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Vogl, MR et al. (2013) Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J. Neurosci. 33 6679-90 PubMed GONUTS page
↑ Krebs, AR et al. (2010) ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep. 11 541-7 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20589884-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Rocha, PP et al. (2010) Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis. Birth Defects Res. Part A Clin. Mol. Teratol. 88 626-32 PubMed GONUTS page

[PMID:20630950-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Rocha, PP et al. (2010) Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137 2723-31 PubMed GONUTS page

[PMID:20720539-4] 4.0 ^4.1 Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:15340084-5] Malik, S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol. Cell. Biol. 24 8244-54 PubMed GONUTS page

[PMID:23575864-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Vogl, MR et al. (2013) Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J. Neurosci. 33 6679-90 PubMed GONUTS page

[PMID:20508642-7] Krebs, AR et al. (2010) ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. EMBO Rep. 11 541-7 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MOUSE:MED12

Contents

Annotations

Notes

References

a

b

c

e

g

h

m

n

o

p

r

s

t

u

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools