name: mediator complex
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def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "CDK8-containing TRAP/mediator complex" RELATED 
synonym: "L mediator complex" EXACT 
synonym: "Srb-mediator complex" EXACT [GOC:mah]
synonym: "TRAP complex" NARROW 
is_a: GO:0032991 ! protein-containing complex
relationship: has_part: GO:0070847 ! core mediator complex
relationship: part_of: GO:0005654 ! nucleoplasm
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