GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:CDK8

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDK8
Protein Name(s) Cyclin-dependent kinase 8

Cell division protein kinase 8 Mediator complex subunit CDK8 Mediator of RNA polymerase II transcription subunit CDK8 Protein kinase K35

External Links
UniProt P49336
EMBL X85753
AL590108
AL159159
AL159159
AL590108
CH471075
CH471075
BC069634
BC104492
BC105950
BC107601
CCDS CCDS9317.1
PIR I37227
RefSeq NP_001251.1
NP_001305297.1
UniGene Hs.382306
Hs.695166
PDB 3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
PDBsum 3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
ProteinModelPortal P49336
SMR P49336
BioGrid 107458
DIP DIP-32595N
IntAct P49336
MINT MINT-3017285
STRING 9606.ENSP00000370938
BindingDB P49336
ChEMBL CHEMBL5719
DrugBank DB03496
GuidetoPHARMACOLOGY 1980
iPTMnet P49336
PhosphoSitePlus P49336
BioMuta CDK8
DMDM 1345718
EPD P49336
MaxQB P49336
PaxDb P49336
PeptideAtlas P49336
PRIDE P49336
DNASU 1024
Ensembl ENST00000381527
GeneID 1024
KEGG hsa:1024
UCSC uc001uqr.2
CTD 1024
DisGeNET 1024
GeneCards CDK8
HGNC HGNC:1779
HPA HPA044721
MIM 603184
neXtProt NX_P49336
OpenTargets ENSG00000132964
PharmGKB PA26315
eggNOG KOG0666
ENOG410XPPA
GeneTree ENSGT00530000064012
HOGENOM HOG000233024
HOVERGEN HBG014652
InParanoid P49336
KO K02208
OMA KHVNVIT
OrthoDB EOG091G0812
PhylomeDB P49336
TreeFam TF101025
BRENDA 2.7.11.22
Reactome [www.reactome.org/content/detail/R-HSA-1989781 R-HSA-1989781]
[www.reactome.org/content/detail/R-HSA-2122947 R-HSA-2122947]
[www.reactome.org/content/detail/R-HSA-212436 R-HSA-212436]
[www.reactome.org/content/detail/R-HSA-2173796 R-HSA-2173796]
[www.reactome.org/content/detail/R-HSA-2644606 R-HSA-2644606]
[www.reactome.org/content/detail/R-HSA-2894862 R-HSA-2894862]
[www.reactome.org/content/detail/R-HSA-381340 R-HSA-381340]
SignaLink P49336
SIGNOR P49336
ChiTaRS CDK8
GeneWiki Cyclin-dependent_kinase_8
GenomeRNAi 1024
PRO PR:P49336
Proteomes UP000005640
Bgee ENSG00000132964
CleanEx HS_CDK8
ExpressionAtlas P49336
Genevisible P49336
GO GO:0016592
GO:0005730
GO:0005654
GO:0005634
GO:0043234
GO:0005524
GO:0004693
GO:0004672
GO:0004674
GO:0008353
GO:0045944
GO:0007346
GO:0006367
InterPro IPR011009
IPR000719
IPR017441
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016592

mediator complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015618
MGI:MGI:1196224
PANTHER:PTN000623092
PomBase:SPAC23H4.17c
SGD:S000005963
UniProtKB:P49336

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013435
FB:FBgn0013762
FB:FBgn0015618
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
RGD:621124
RGD:70514
SGD:S000001622
SGD:S000001865
SGD:S000005488
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2119961
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q9UQ88
WB:WBGene00000405
WB:WBGene00000407
WB:WBGene00019362
ZFIN:ZDB-GENE-040808-34
dictyBase:DDB_G0267442
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015618
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:102956
MGI:MGI:104772
MGI:MGI:1328368
MGI:MGI:88353
MGI:MGI:88357
MGI:MGI:894318
PANTHER:PTN000623091
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC32H8.10
RGD:1305435
RGD:1359638
RGD:2319
RGD:619874
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000002266
SGD:S000005952
TAIR:locus:2008595
TAIR:locus:2027819
TAIR:locus:2033349
TAIR:locus:2080290
TAIR:locus:2084086
TAIR:locus:2099478
TAIR:locus:2119961
TAIR:locus:2158554
TAIR:locus:2194045
UniProtKB:O76039
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P49336
UniProtKB:P50613
UniProtKB:P61075
UniProtKB:P79432
UniProtKB:Q00534
UniProtKB:Q00535
UniProtKB:Q00646
UniProtKB:Q5B3E4
UniProtKB:Q8IDW1
UniProtKB:Q8IIL5
UniProtKB:Q8IJQ1
UniProtKB:Q8RWN3
UniProtKB:Q8W4P1
UniProtKB:Q92772
UniProtKB:Q96VK3
UniProtKB:Q9NYV4
UniProtKB:Q9UQ88
WB:WBGene00000405
dictyBase:DDB_G0267442
dictyBase:DDB_G0288677

C

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013762
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
PomBase:SPAC23H4.17c
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC19F8.07
PomBase:SPBC32H8.10
RGD:2319
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2011761
UniProtKB:A0A1D8PDA6
UniProtKB:C9K505
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:P61075
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q8IJQ1
WB:WBGene00000405
ZFIN:ZDB-GENE-010131-2
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:22869755[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016592

mediator complex

PMID:14638676[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:22869755[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16109376[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004693

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004693

P

Seeded From UniProt

complete

part_of

GO:0016592

mediator complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R3L8
ensembl:ENSMUSP00000031640

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0008283

cell proliferation

PMID:28416637[5]

ECO:0000316

P

Expression of CDK8 rescues the proliferation defect in shCDK19 cells treated with Nutlin-3.

Missing: with/from
CACAO 12755

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.23

F

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.22

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:7568034[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

Reactome:R-HSA-2173796

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:R-HSA-212436

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-NUL-2065178
Reactome:R-NUL-2064916
Reactome:R-HSA-2220971
Reactome:R-HSA-2220957
Reactome:R-HSA-2176475
Reactome:R-HSA-212432
Reactome:R-HSA-212380
Reactome:R-HSA-212352

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 Porter, DC et al. (2012) Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc. Natl. Acad. Sci. U.S.A. 109 13799-804 PubMed GONUTS page
  3. ↑ Tomomori-Sato, C et al. (2004) A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. J. Biol. Chem. 279 5846-51 PubMed GONUTS page
  4. ↑ Jang, MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19 523-34 PubMed GONUTS page
  5. ↑ Audetat, KA et al. (2017) A kinase-independent role for CDK19 in p53 response. Mol. Cell. Biol. PubMed GONUTS page
  6. ↑ Tassan, JP et al. (1995) Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 92 8871-5 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:CDK8&oldid=5954698"