HUMAN:CDK19

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CDK19 (synonyms: CDC2L6, CDK11, KIAA1028)
Protein Name(s)	Cyclin-dependent kinase 19 CDC2-related protein kinase 6 Cell division cycle 2-like protein kinase 6 Cell division protein kinase 19 Cyclin-dependent kinase 11 Death-preventing kinase
External Links
UniProt	Q9BWU1
EMBL	AY028424 Z84480 AL512430 AL603914 AL512430 AL603914 AL512430 AL603914 Z84480 AL603914 AL512430 AL603914 AL512430 Z84480 BC024247 BC037289 AB028951
CCDS	CCDS5085.1 CCDS75503.1
RefSeq	NP_001287889.1 NP_001287892.1 NP_001287893.1 NP_055891.1
UniGene	Hs.744895
ProteinModelPortal	Q9BWU1
SMR	Q9BWU1
BioGrid	116725
DIP	DIP-29013N
IntAct	Q9BWU1
STRING	9606.ENSP00000357907
BindingDB	Q9BWU1
ChEMBL	CHEMBL6002
GuidetoPHARMACOLOGY	1972
iPTMnet	Q9BWU1
PhosphoSitePlus	Q9BWU1
BioMuta	CDK19
DMDM	60391917
EPD	Q9BWU1
MaxQB	Q9BWU1
PaxDb	Q9BWU1
PeptideAtlas	Q9BWU1
PRIDE	Q9BWU1
DNASU	23097
Ensembl	ENST00000323817 ENST00000368911
GeneID	23097
KEGG	hsa:23097
UCSC	uc003puh.2
CTD	23097
DisGeNET	23097
GeneCards	CDK19
HGNC	HGNC:19338
HPA	HPA007053
MIM	614720
neXtProt	NX_Q9BWU1
OpenTargets	ENSG00000155111
PharmGKB	PA165617767
eggNOG	KOG0666 ENOG410XPPA
GeneTree	ENSGT00530000064012
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	Q9BWU1
KO	K02208
OMA	SQSTMGY
OrthoDB	EOG091G0812
PhylomeDB	Q9BWU1
TreeFam	TF101025
Reactome	[www.reactome.org/content/detail/R-HSA-1989781 R-HSA-1989781] [www.reactome.org/content/detail/R-HSA-381340 R-HSA-381340]
SignaLink	Q9BWU1
SIGNOR	Q9BWU1
ChiTaRS	CDK19
GenomeRNAi	23097
PRO	PR:Q9BWU1
Proteomes	UP000005640
Bgee	ENSG00000155111
CleanEx	HS_CDC2L6
ExpressionAtlas	Q9BWU1
Genevisible	Q9BWU1
GO	GO:0005829 GO:0005634 GO:0005524 GO:0004693 GO:0071222 GO:0043065 GO:0050729 GO:0006468 GO:0007346
InterPro	IPR011009 IPR000719 IPR017441 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008283	cell proliferation	PMID:28416637^[1]	ECO:0000316			P	Expression of CDK8 rescues the proliferation defect in shCDK19 cells treated with Nutlin-3.	Missing: with/from CACAO 12754
part_of	GO:0016592	mediator complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 MGI:MGI:1196224 PANTHER:PTN000623092 PomBase:SPAC23H4.17c SGD:S000005963 UniProtKB:P49336	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623123 RGD:1305435	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZDM6 ensembl:ENSRNOP00000000713	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZDM6 ensembl:ENSRNOP00000000713	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZDM6 ensembl:ENSRNOP00000000713	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZDM6 ensembl:ENSRNOP00000000713	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZDM6 ensembl:ENSRNOP00000000713	C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.22	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Audetat, KA et al. (2017) A kinase-independent role for CDK19 in p53 response. Mol. Cell. Biol. PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:28416637-1] Audetat, KA et al. (2017) A kinase-independent role for CDK19 in p53 response. Mol. Cell. Biol. PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:CDK19

Contents

Annotations

Notes

References

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