MOUSE:PRGC2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ppargc1b (synonyms: Errl1, Pgc1, Pgc1b, Ppargc1)
Protein Name(s)	Peroxisome proliferator-activated receptor gamma coactivator 1-beta PGC-1-beta PPAR-gamma coactivator 1-beta PPARGC-1-beta ERR ligand 1
External Links
UniProt	Q8VHJ7
EMBL	AF453324 AK028464
CCDS	CCDS29284.1
RefSeq	NP_573512.1
UniGene	Mm.415302
ProteinModelPortal	Q8VHJ7
SMR	Q8VHJ7
BioGrid	228460
IntAct	Q8VHJ7
STRING	10090.ENSMUSP00000074771
PhosphoSite	Q8VHJ7
PRIDE	Q8VHJ7
Ensembl	ENSMUST00000063307 ENSMUST00000075299
GeneID	170826
KEGG	mmu:170826
UCSC	uc008fbx.1 uc012bdq.1
CTD	133522
MGI	MGI:2444934
eggNOG	NOG87590
GeneTree	ENSGT00530000063196
HOGENOM	HOG000236356
HOVERGEN	HBG080730
InParanoid	Q8VHJ7
KO	K17962
OMA	CESGCGD
OrthoDB	EOG7S4X5H
PhylomeDB	Q8VHJ7
TreeFam	TF343068
Reactome	R-MMU-2151201
ChiTaRS	Ppargc1b
NextBio	370487
PRO	PR:Q8VHJ7
Proteomes	UP000000589
Bgee	Q8VHJ7
Genevisible	Q8VHJ7
GO	GO:0016592 GO:0005739 GO:0005654 GO:0005634 GO:0050682 GO:0030331 GO:0030374 GO:0000166 GO:0030546 GO:0003723 GO:0001104 GO:0008134 GO:0007015 GO:0060346 GO:0034614 GO:0030520 GO:0045892 GO:0001503 GO:0010694 GO:0045780 GO:0045672 GO:0042327 GO:2000273 GO:0051091 GO:0045944 GO:0045893 GO:0006355 GO:0051591 GO:0051384 GO:0006390 GO:0006366
Gene3D	3.30.70.330
InterPro	IPR012677 IPR000504
Pfam	PF00076
SMART	SM00360
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:17090215^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060346	bone trabecula formation	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045672	positive regulation of osteoclast differentiation	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:19252502^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001503	ossification	PMID:19252502^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050682	AF-2 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86YN6	C	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 UniProtKB:Q9UBK2	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037248 MGI:MGI:1342774 PANTHER:PTN000399017 RGD:620925 UniProtKB:Q86YN6 UniProtKB:Q9UBK2	C	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000399017 UniProtKB:Q86YN6	F	Seeded From UniProt	complete
enables	GO:0050682	AF-2 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	C	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86YN6	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0006390	C	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q811R2 ensembl:ENSRNOP00000023661	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q811R2 ensembl:ENSRNOP00000023661	P	Seeded From UniProt	complete
enables	GO:0050682	AF-2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	P	Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	F	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	F	Seeded From UniProt	complete
part_of	GO:0016592	mediator complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	C	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86YN6 ensembl:ENSP00000312649	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F	Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034621	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034605 InterPro:IPR034621	F	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034621	F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-1605530	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lelliott, CJ et al. (2006) Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 4 e369 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Ishii, KA et al. (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat. Med. 15 259-66 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17090215-1] Lelliott, CJ et al. (2006) Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 4 e369 PubMed GONUTS page

[PMID:19252502-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Ishii, KA et al. (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat. Med. 15 259-66 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:PRGC2

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