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HUMAN:RBM14

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RBM14 (synonyms: SIP)
Protein Name(s) RNA-binding protein 14

Paraspeckle protein 2 PSP2 RNA-binding motif protein 14 RRM-containing coactivator activator/modulator Synaptotagmin-interacting protein SYT-interacting protein

External Links
UniProt Q96PK6
EMBL AF315632
AF315633
DQ294957
EU287938
AF080561
AK021768
AK222830
AP001157
CH471076
BC000488
BE885635
CR749306
CCDS CCDS55772.1
CCDS55773.1
CCDS8147.1
RefSeq NP_001185765.1
NP_001185766.1
NP_001185774.1
NP_001185775.1
NP_006319.1
UniGene Hs.523822
Hs.533712
PDB 2DNP
PDBsum 2DNP
ProteinModelPortal Q96PK6
SMR Q96PK6
BioGrid 115700
IntAct Q96PK6
MINT MINT-2798129
STRING 9606.ENSP00000311747
PhosphoSite Q96PK6
DMDM 73913750
MaxQB Q96PK6
PaxDb Q96PK6
PRIDE Q96PK6
DNASU 10432
Ensembl ENST00000310137
ENST00000393979
ENST00000409738
GeneID 100526737
10432
KEGG hsa:100526737
hsa:10432
UCSC uc001oit.3
uc009yri.3
CTD 100526737
10432
GeneCards GC11P066384
HGNC HGNC:14219
HPA HPA006628
MIM 612409
neXtProt NX_Q96PK6
PharmGKB PA34263
eggNOG COG0724
GeneTree ENSGT00390000020883
HOGENOM HOG000065673
HOVERGEN HBG053180
InParanoid Q96PK6
KO K13189
OMA GSYSEYL
OrthoDB EOG7SFJ0M
PhylomeDB Q96PK6
TreeFam TF320661
ChiTaRS RBM14
EvolutionaryTrace Q96PK6
GeneWiki RBM14
NextBio 34054915
PRO PR:Q96PK6
Proteomes UP000005640
Bgee Q96PK6
ExpressionAtlas Q96PK6
Genevestigator Q96PK6
GO GO:0016592
GO:0005634
GO:0030529
GO:0005667
GO:0030374
GO:0000166
GO:0044822
GO:0030674
GO:0003723
GO:0001104
GO:0006310
GO:0006281
GO:0006260
GO:0042921
GO:0016575
GO:0030520
GO:0045944
GO:0009725
GO:0006366
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046600

negative regulation of centriole replication

PMID:25385835[1]

ECO:0000315

P

Figure 1 shows an increase in various centriolar complex proteins in mitotic cells that underwent siRNA mediated RBM14 knockdown compared to mitotic cells that did not undergo knockdown.

complete
CACAO 10347

part_of

GO:0005737

cytoplasm

PMID:25385835[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:25385835[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098534

centriole assembly

PMID:25385835[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

PMID:28712728[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046600

negative regulation of centriole replication

PMID:25385835[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15919756[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:11443112[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042921

glucocorticoid receptor signaling pathway

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030674

protein binding, bridging

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:11443112[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q14686

F

Seeded From UniProt

complete

part_of

GO:0016592

mediator complex

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

PMID:11443112[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q92793

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006260

DNA replication

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:11443112[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P09874

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:11443112[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P13010

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003712

transcription coregulator activity

PMID:11443112[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000609209
UniProtKB:Q96PK6

P

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000609209
UniProtKB:Q96PK6

F

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004587
FB:FBgn0265298
MGI:MGI:98283
MGI:MGI:98284
MGI:MGI:98285
MGI:MGI:98287
PANTHER:PTN000567445
RGD:1359422
TAIR:locus:2024770
TAIR:locus:2035651
TAIR:locus:2049766
TAIR:locus:2079502
TAIR:locus:2086804
TAIR:locus:2099931
TAIR:locus:2124799
TAIR:locus:2131864
TAIR:locus:2144945
TAIR:locus:2173338
TAIR:locus:2199837
UniProtKB:O75494
UniProtKB:P84103
UniProtKB:Q01130
UniProtKB:Q07955
UniProtKB:Q08170
UniProtKB:Q13247
UniProtKB:Q96PK6
UniProtKB:Q9BRL6
UniProtKB:Q9BWF3

C

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000609209
UniProtKB:Q96PK6

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004587
FB:FBgn0011305
FB:FBgn0011640
FB:FBgn0028554
FB:FBgn0260944
FB:FBgn0265298
FB:FBgn0283477
MGI:MGI:1100865
MGI:MGI:1333805
MGI:MGI:1921361
MGI:MGI:98283
MGI:MGI:98284
MGI:MGI:98285
MGI:MGI:98287
PANTHER:PTN000567445
PomBase:SPBC11C11.08
RGD:1309233
RGD:1359241
RGD:1359422
RGD:1561347
RGD:1587490
RGD:3664
TAIR:locus:2024770
TAIR:locus:2035651
TAIR:locus:2046638
TAIR:locus:2049766
TAIR:locus:2079502
TAIR:locus:2086804
TAIR:locus:2099931
TAIR:locus:2114643
TAIR:locus:2117706
TAIR:locus:2119797
TAIR:locus:2122990
TAIR:locus:2124799
TAIR:locus:2131864
TAIR:locus:2144945
TAIR:locus:2173088
TAIR:locus:2173338
TAIR:locus:2199837
UniProtKB:O75494
UniProtKB:P84103
UniProtKB:Q01130
UniProtKB:Q07955
UniProtKB:Q08170
UniProtKB:Q13242
UniProtKB:Q13243
UniProtKB:Q13247
UniProtKB:Q16629
UniProtKB:Q8I3T5
UniProtKB:Q8I468
UniProtKB:Q96PK6
UniProtKB:Q9BQ04
UniProtKB:Q9BRL6
UniProtKB:Q9BWF3
UniProtKB:Q9Y4C8
WB:WBGene00004315
WB:WBGene00004699
WB:WBGene00004701
WB:WBGene00004703

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011640
PANTHER:PTN000567445
RGD:3664
SGD:S000001016
UniProtKB:O75494
UniProtKB:P84103
UniProtKB:Q07955
UniProtKB:Q13247
UniProtKB:Q9BWF3

F

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000609209
UniProtKB:Q96PK6

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098534

centriole assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C2Q3
ensembl:ENSMUSP00000006625

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C2Q3
ensembl:ENSMUSP00000006625

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:11443112[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

PMID:11443112[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8938356

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Shiratsuchi, G et al. (2015) RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. EMBO J. 34 97-114 PubMed GONUTS page
  2. ↑ Morchikh, M et al. (2017) HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol. Cell 67 387-399.e5 PubMed GONUTS page
  3. ↑ Iwasaki, T et al. (2005) Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology 146 3892-9 PubMed GONUTS page
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 Iwasaki, T et al. (2001) Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J. Biol. Chem. 276 33375-83 PubMed GONUTS page
  5. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  6. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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