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Category:GO:0060395 ! SMAD protein signal transduction
name: SMAD protein signal transduction
namespace: biological_process
def: "An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]
comment: Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.
is_a: GO:0141124 ! intracellular signaling cassette
relationship: part_of: GO:0007178 ! cell surface receptor protein serine/threonine kinase signaling pathway
AmiGO
<GOterm>GO:0060395</GOterm>
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