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HUMAN:LCAP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LNPEP (synonyms: OTASE)
Protein Name(s) Leucyl-cystinyl aminopeptidase

Cystinyl aminopeptidase Insulin-regulated membrane aminopeptidase Insulin-responsive aminopeptidase IRAP Oxytocinase OTase Placental leucine aminopeptidase P-LAP Leucyl-cystinyl aminopeptidase, pregnancy serum form

External Links
UniProt Q9UIQ6
EMBL D50810
U62768
U62769
AJ131023
AJ131025
AJ131026
AJ131027
AJ131028
AJ131029
AJ131030
AJ131031
AJ131032
AJ131033
AJ131034
AJ131035
AJ131036
AJ131037
AJ131038
AJ131039
AJ131025
AJ131026
AJ131027
AJ131028
AJ131029
AJ131030
AJ131031
AJ131032
AJ131033
AJ131034
AJ131035
AJ131036
AJ131037
AJ131038
AJ131039
AB208883
CCDS CCDS4087.1
CCDS43346.1
PIR A59383
A59384
RefSeq NP_005566.2
NP_787116.2
UniGene Hs.527199
Hs.656905
ProteinModelPortal Q9UIQ6
SMR Q9UIQ6
BioGrid 110196
IntAct Q9UIQ6
STRING 9606.ENSP00000231368
BindingDB Q9UIQ6
ChEMBL CHEMBL2693
MEROPS M01.011
PhosphoSite Q9UIQ6
DMDM 145559489
MaxQB Q9UIQ6
PaxDb Q9UIQ6
PeptideAtlas Q9UIQ6
PRIDE Q9UIQ6
DNASU 4012
Ensembl ENST00000231368
ENST00000395770
GeneID 4012
KEGG hsa:4012
UCSC uc003kmv.1
CTD 4012
GeneCards GC05P096272
H-InvDB HIX0005054
HGNC HGNC:6656
HPA HPA043642
MIM 151300
neXtProt NX_Q9UIQ6
PharmGKB PA30418
eggNOG COG0308
GeneTree ENSGT00760000119082
HOVERGEN HBG108296
InParanoid Q9UIQ6
KO K01257
OMA TEEVQWI
OrthoDB EOG754HNR
PhylomeDB Q9UIQ6
TreeFam TF300395
Reactome REACT_111168
REACT_147867
REACT_75842
SABIO-RK Q9UIQ6
ChiTaRS LNPEP
GeneWiki Cystinyl_aminopeptidase
GenomeRNAi 4012
NextBio 15736
PMAP-CutDB Q9UIQ6
PRO PR:Q9UIQ6
Proteomes UP000005640
Bgee Q9UIQ6
CleanEx HS_LNPEP
Genevestigator Q9UIQ6
GO GO:0030659
GO:0005829
GO:0031905
GO:0005576
GO:0005887
GO:0005622
GO:0005765
GO:0016020
GO:0048471
GO:0005886
GO:0004177
GO:0008237
GO:0008270
GO:0042590
GO:0002480
GO:0002474
GO:0007267
GO:0007565
GO:0061024
GO:0030163
GO:0000209
GO:0006508
InterPro IPR024571
IPR001930
IPR014782
PANTHER PTHR11533
Pfam PF11838
PF01433
PRINTS PR00756
PROSITE PS00142

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004178

leucyl aminopeptidase activity

PMID:14170024[1]

ECO:0000314

F

catalysis of the release of a N-terminal amino acid

complete
CACAO 10577

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

PMID:25534853[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8C129

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11108258[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:17897319[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070006

metalloaminopeptidase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000164250
SGD:S000001640
UniProtKB:Q07075
WB:WBGene00003914

F

Seeded From UniProt

complete

involved_in

GO:0043171

peptide catabolic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000164250
RGD:621752
SGD:S000001640
WB:WBGene00003914

P

Seeded From UniProt

complete

enables

GO:0042277

peptide binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000164250
RGD:2991
RGD:621228

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000164250
RGD:708542
dictyBase:DDB_G0270994

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1933403
MGI:MGI:5000466
PANTHER:PTN000164251
RGD:2991
RGD:621228
RGD:708542
SGD:S000001089

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1933403
PANTHER:PTN000164250
RGD:621752
WB:WBGene00003914
dictyBase:DDB_G0270994

C

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

PMID:19918052[7]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

PMID:19498108[8]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

C

Seeded From UniProt

complete

involved_in

GO:0030163

protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

C

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8C129
ensembl:ENSMUSP00000036998

F

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034017

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001930
InterPro:IPR034017

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014782

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR014782

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:8550619[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

PMID:9177475[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:8550619[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007267

cell-cell signaling

PMID:8550619[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:8550619[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

PMID:15691326[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031905

early endosome lumen

Reactome:R-HSA-1236954

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-983162

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002480

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Reactome:R-HSA-1236977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

Reactome:R-HSA-983168

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004177

aminopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0031

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ D ONOFRIO, F et al. (1964) [LEUCINE AMINOPEPTIDASE OF THE SERUM IN VARIOUS CLINICAL FORMS OF DISEASES OF THE HEPATO-BILIARY APPARATUS]. Fegato 10 50-64 PubMed GONUTS page
  2. ↑ Niwa, M et al. (2015) IRAP deficiency attenuates diet-induced obesity in mice through increased energy expenditure. Biochem. Biophys. Res. Commun. 457 12-8 PubMed GONUTS page
  3. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. ↑ Nakamura, H et al. (2000) Oxytocin stimulates the translocation of oxytocinase of human vascular endothelial cells via activation of oxytocin receptors. Endocrinology 141 4481-5 PubMed GONUTS page
  5. ↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Segura, E et al. (2009) Different cross-presentation pathways in steady-state and inflammatory dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 106 20377-81 PubMed GONUTS page
  8. ↑ Saveanu, L et al. (2009) IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science 325 213-7 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Rogi, T et al. (1996) Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. J. Biol. Chem. 271 56-61 PubMed GONUTS page
  10. ↑ Laustsen, PG et al. (1997) The complete amino acid sequence of human placental oxytocinase. Biochim. Biophys. Acta 1352 1-7 PubMed GONUTS page
  11. ↑ Tanioka, T et al. (2005) Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma. FEBS J. 272 916-28 PubMed GONUTS page
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