BOVIN:GDF8

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	MSTN (synonyms: GDF8, MH)
Protein Name(s)	Growth/differentiation factor 8 GDF-8 Myostatin
External Links
UniProt	O18836
EMBL	AF019761 AF019620 AF320998 AB076403 AY160688 AY850105 BC134563
RefSeq	NP_001001525.1
UniGene	Bt.605
ProteinModelPortal	O18836
Ensembl	ENSBTAT00000015674
GeneID	281187
KEGG	bta:281187
CTD	2660
eggNOG	NOG310007
GeneTree	ENSGT00760000119112
HOGENOM	HOG000006566
HOVERGEN	HBG000217
InParanoid	O18836
KO	K05497
OMA	NPFLEVR
OrthoDB	EOG74R1Q4
TreeFam	TF318514
NextBio	20805244
Proteomes	UP000009136
ExpressionAtlas	O18836
GO	GO:0005615 GO:0008201 GO:0071549 GO:0040007 GO:0045893 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR015616 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848 PTHR11848:SF13
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:9314496^[1]	ECO:0000315			P	Figure 2; expression of non-functional allele in cattle	complete CACAO 2285
	GO:0048147	negative regulation of fibroblast proliferation	PMID:23268959^[2]	ECO:0000314			P	Figure 1; Indicates a significant inhibition of fibroblast [NIH3T3, mouse] cell proliferation by myostatin [recombinant, bovine] compared to control. Myostatin fibroblast inhibition directly stated in: Results Section/1st paragraph/last sentence.	complete CACAO 6520
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08689	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	PMID:23268959^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0046716	C	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08689 ensembl:ENSMUSP00000027269	F	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kambadur, R et al. (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 7 910-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Z Hosaka, Y et al. (2012) Myostatin regulates proliferation and extracellular matrix mRNA expression in NIH3T3 fibroblasts. Biomed. Res. 33 355-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9314496-1] Kambadur, R et al. (1997) Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 7 910-6 PubMed GONUTS page

[PMID:23268959-2] 2.0 ^2.1 Z Hosaka, Y et al. (2012) Myostatin regulates proliferation and extracellular matrix mRNA expression in NIH3T3 fibroblasts. Biomed. Res. 33 355-61 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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BOVIN:GDF8

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References

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