MOUSE:GDF8

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mstn (synonyms: Gdf8)
Protein Name(s)	Growth/differentiation factor 8 GDF-8 Myostatin
External Links
UniProt	O08689
EMBL	U84005
CCDS	CCDS14950.1
RefSeq	NP_034964.1
UniGene	Mm.3514
PDB	3HH2 3SEK
PDBsum	3HH2 3SEK
ProteinModelPortal	O08689
SMR	O08689
BioGrid	201535
IntAct	O08689
MINT	MINT-7914794
PhosphoSite	O08689
PaxDb	O08689
PRIDE	O08689
Ensembl	ENSMUST00000027269
GeneID	17700
KEGG	mmu:17700
UCSC	uc007ayt.1
CTD	2660
MGI	MGI:95691
eggNOG	NOG310007
HOGENOM	HOG000006566
HOVERGEN	HBG000217
InParanoid	O08689
KO	K05497
OMA	NPFLEVR
OrthoDB	EOG74R1Q4
PhylomeDB	O08689
TreeFam	TF318514
EvolutionaryTrace	O08689
NextBio	292290
PRO	PR:O08689
Proteomes	UP000000589
Bgee	O08689
CleanEx	MM_MSTN
ExpressionAtlas	O08689
Genevestigator	O08689
GO	GO:0005737 GO:0005615 GO:0008201 GO:0005102 GO:0071549 GO:0014741 GO:0048632 GO:0022602 GO:0045893 GO:0051602 GO:0043627 GO:0045471 GO:0009629 GO:0009408 GO:0014850 GO:0033574 GO:0014732 GO:0043403 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR015616 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848 PTHR11848:SF13
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:9139826^[1]	ECO:0000315			P	Fig 4a-d; disruption of GDF-8's normal functioning	complete CACAO 2282
	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:21390326^[2]	ECO:0000315			P	Table 1 and Figure 2 show the Gastrocnemius, Quadriceps, and Triceps muscles all were significantly larger in weight(g) in myostatin deficient mice compared to normal myostatin mice.	complete CACAO 3684
	GO:0019222	regulation of metabolic process	PMID:11877467^[3]	ECO:0000315			P	Table 2 shows Mstn–/– mice had higher rates of total and resting O2 consumption compared with Mstn+/+ mice, which is expected given the higher body weights of Mstn–/– mice. If the data are expressed as a function of body weight, however, Mstn–/– mice actually had lower rates of total and resting O2 consumption compared with Mstn+/+ mice.	complete CACAO 3737
	GO:0019217	regulation of fatty acid metabolic process	PMID:21390326^[2]	ECO:0000315			P	Figure 4 shows mg fatty acids per g of muscle tissue is significantly less in myostatin depleted mice fed a high-fat diet.	complete CACAO 3741
	GO:0043610	regulation of carbohydrate utilization	PMID:21390326^[2]	ECO:0000315			P	Figure 3 shows blood glucose concentration is significantly lower in myostatin depleted mice fed a high-fat diet for 5 months, 90 min after ip glucose injection.	complete CACAO 3743
	GO:0019216		PMID:21390326^[2]	ECO:0000315				Figure 5 shows that myostatin depleted mice have a significantly lower incidence and severity of hepatic statosis when fed a high-fat diet for 5 months.	complete CACAO 3746
	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:11877467^[3]	ECO:0000315			P	Figure 1a shows the increased mass of triceps muscle in Mstn -/- mice at different ages as well as an apparent dose-dependency on muscle mass.	complete CACAO 3750
	GO:0019216	regulation of lipid metabolic process	PMID:11877467^[3]	ECO:0000315			P	Figure 1b-g shows the significant differences in fat pad mass between Mstn -/- and Mstn +/+ mice after 2 months of age.	complete CACAO 3753
	GO:0033673	negative regulation of kinase activity	PMID:19357233^[4]	ECO:0000315			P	Results section/ Increased muscle weight and CK activity... Section; Fig. 7 B; Show Creatine Kinase activity increased by myostatin expression inhitbion in vivo [mice], activity bio marker used. Mice had Severe Combined Immunodeficiency and no MSTN mutations	complete CACAO 6339
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:16182246^[5]	ECO:0000315			P	Responses of insulin action.. Section; Fig 3; muscle protein kinase Akt intermediate phosphorylation was measured due to is role in the insulin signaling pathway, transgenic mice showed greater levels [inhibition of myostatin] of phosphorylation	complete CACAO 6340
involved_in	GO:0014839	myoblast migration involved in skeletal muscle regeneration	PMID:19406121^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	PMID:19406121^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	PMID:19406121^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:28257634^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:28257634^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:19644449^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19644449^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:24076600^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:16182246^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	PMID:19357233^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000818	negative regulation of myoblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902725	negative regulation of satellite cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:1902723	negative regulation of skeletal muscle satellite cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O42221	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:11877467^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:21390326^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:9139826^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12595574^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071549	cellular response to dexamethasone stimulus	PMID:23752591^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:18286185^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3778375	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048632	negative regulation of skeletal muscle tissue growth	PMID:18286185^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2148177	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3115	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014741	negative regulation of muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3115	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:12595574^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3115	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3115	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11459935^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27038 UniProtKB:P27040	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14793	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14793 ensembl:ENSP00000260950	F	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0048632	negative regulation of skeletal muscle tissue growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0022602	ovulation cycle process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014741	negative regulation of muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0014732	skeletal muscle atrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35312 ensembl:ENSRNOP00000038159	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015616	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR015616 InterPro:IPR017948	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-9625523	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 McPherron, AC et al. (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387 83-90 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Burgess, K et al. (2011) Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. PLoS ONE 6 e17090 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 McPherron, AC & Lee, SJ (2002) Suppression of body fat accumulation in myostatin-deficient mice. J. Clin. Invest. 109 595-601 PubMed GONUTS page
↑ ^4.0 ^4.1 Trendelenburg, AU et al. (2009) Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am. J. Physiol., Cell Physiol. 296 C1258-70 PubMed GONUTS page
↑ ^5.0 ^5.1 Zhao, B et al. (2005) Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochem. Biophys. Res. Commun. 337 248-55 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Salerno, MS et al. (2009) Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis. Exp. Cell Res. 315 2012-21 PubMed GONUTS page
↑ ^7.0 ^7.1 Walker, RG et al. (2017) Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 15 19 PubMed GONUTS page
↑ ^8.0 ^8.1 Cash, JN et al. (2009) The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. EMBO J. 28 2662-76 PubMed GONUTS page
↑ Sartori, R et al. (2013) BMP signaling controls muscle mass. Nat. Genet. 45 1309-18 PubMed GONUTS page
↑ ^10.0 ^10.1 Hill, JJ et al. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol. Endocrinol. 17 1144-54 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page
↑ ^13.0 ^13.1 Lee, SJ (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3 e1628 PubMed GONUTS page
↑ Lee, SJ & McPherron, AC (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci. U.S.A. 98 9306-11 PubMed GONUTS page

[PMID:9139826-1] 1.0 ^1.1 McPherron, AC et al. (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387 83-90 PubMed GONUTS page

[PMID:21390326-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Burgess, K et al. (2011) Effect of myostatin depletion on weight gain, hyperglycemia, and hepatic steatosis during five months of high-fat feeding in mice. PLoS ONE 6 e17090 PubMed GONUTS page

[PMID:11877467-3] 3.0 ^3.1 ^3.2 ^3.3 McPherron, AC & Lee, SJ (2002) Suppression of body fat accumulation in myostatin-deficient mice. J. Clin. Invest. 109 595-601 PubMed GONUTS page

[PMID:19357233-4] 4.0 ^4.1 Trendelenburg, AU et al. (2009) Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am. J. Physiol., Cell Physiol. 296 C1258-70 PubMed GONUTS page

[PMID:16182246-5] 5.0 ^5.1 Zhao, B et al. (2005) Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochem. Biophys. Res. Commun. 337 248-55 PubMed GONUTS page

[PMID:19406121-6] 6.0 ^6.1 ^6.2 Salerno, MS et al. (2009) Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis. Exp. Cell Res. 315 2012-21 PubMed GONUTS page

[PMID:28257634-7] 7.0 ^7.1 Walker, RG et al. (2017) Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 15 19 PubMed GONUTS page

[PMID:19644449-8] 8.0 ^8.1 Cash, JN et al. (2009) The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. EMBO J. 28 2662-76 PubMed GONUTS page

[PMID:24076600-9] Sartori, R et al. (2013) BMP signaling controls muscle mass. Nat. Genet. 45 1309-18 PubMed GONUTS page

[PMID:12595574-10] 10.0 ^10.1 Hill, JJ et al. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol. Endocrinol. 17 1144-54 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23752591-12] Proserpio, V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 27 1299-312 PubMed GONUTS page

[PMID:18286185-13] 13.0 ^13.1 Lee, SJ (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3 e1628 PubMed GONUTS page

[PMID:11459935-14] Lee, SJ & McPherron, AC (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci. U.S.A. 98 9306-11 PubMed GONUTS page

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MOUSE:GDF8

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