GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:BMP4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BMP4 (synonyms: BMP2B, DVR4)
Protein Name(s) Bone morphogenetic protein 4

BMP-4 Bone morphogenetic protein 2B BMP-2B

External Links
UniProt P12644
EMBL M22490
U43842
BC020546
D30751
CCDS CCDS9715.1
PIR C37278
RefSeq NP_001193.2
NP_570911.2
NP_570912.2
XP_005268072.1
UniGene Hs.68879
ProteinModelPortal P12644
SMR P12644
BioGrid 107120
DIP DIP-5795N
IntAct P12644
MINT MINT-1184353
STRING 9606.ENSP00000245451
BindingDB P12644
ChEMBL CHEMBL5350
PhosphoSite P12644
DMDM 115073
PaxDb P12644
PRIDE P12644
DNASU 652
Ensembl ENST00000245451
ENST00000417573
ENST00000558984
ENST00000559087
GeneID 652
KEGG hsa:652
UCSC uc001xal.4
CTD 652
GeneCards GC14M054416
GeneReviews BMP4
HGNC HGNC:1071
HPA CAB006863
MIM 112262
600625
607932
neXtProt NX_P12644
Orphanet 264200
1991
139471
93100
PharmGKB PA25381
eggNOG NOG243555
HOGENOM HOG000249478
HOVERGEN HBG004860
InParanoid P12644
KO K04662
OMA ATLLHMF
OrthoDB EOG7WHH9D
PhylomeDB P12644
TreeFam TF351789
Reactome REACT_150331
SignaLink P12644
GeneWiki Bone_morphogenetic_protein_4
GenomeRNAi 652
NextBio 2648
PRO PR:P12644
Proteomes UP000005640
Bgee P12644
CleanEx HS_BMP4
ExpressionAtlas P12644
Genevestigator P12644
GO GO:0005576
GO:0005615
GO:0005578
GO:0070700
GO:0042056
GO:0005125
GO:0008201
GO:0000186
GO:0009948
GO:0002043
GO:0030509
GO:0003130
GO:0071893
GO:0061151
GO:0061149
GO:0060442
GO:0001658
GO:0048754
GO:0060433
GO:0060503
GO:0060449
GO:0003279
GO:0071363
GO:0002062
GO:0060197
GO:0007182
GO:0060363
GO:0035993
GO:0021904
GO:0048701
GO:0042733
GO:0035116
GO:0060272
GO:0003197
GO:0001958
GO:0060502
GO:0060441
GO:0060684
GO:0030218
GO:0030198
GO:0007281
GO:0072104
GO:0072015
GO:0002244
GO:0060113
GO:0048392
GO:0001822
GO:0060235
GO:0048286
GO:0060425
GO:0002320
GO:0030225
GO:0060592
GO:0072161
GO:0072198
GO:0072138
GO:0003337
GO:0007500
GO:0001823
GO:0072205
GO:0030224
GO:0043066
GO:0072097
GO:0090191
GO:0045786
GO:0060548
GO:0008285
GO:2000137
GO:0032331
GO:0050680
GO:0072125
GO:0090194
GO:0033088
GO:0043407
GO:0072200
GO:2000007
GO:2000005
GO:0045839
GO:0045662
GO:0042326
GO:0060686
GO:0045843
GO:0033085
GO:0070244
GO:0000122
GO:0045892
GO:0001843
GO:0048663
GO:0042476
GO:0042475
GO:0001649
GO:0021983
GO:0050918
GO:0043065
GO:0030513
GO:0030501
GO:0061047
GO:0055020
GO:0061036
GO:0010942
GO:0032967
GO:2000105
GO:0045603
GO:0010595
GO:0001938
GO:0045606
GO:0050679
GO:0070374
GO:0090184
GO:0045666
GO:0045778
GO:0045669
GO:0010862
GO:0032092
GO:0001934
GO:0060391
GO:0048661
GO:0045944
GO:0045893
GO:0009791
GO:0034504
GO:0061155
GO:0060687
GO:0010453
GO:0042487
GO:0060393
GO:0042306
GO:0051150
GO:0072001
GO:0003014
GO:0003139
GO:0060395
GO:0048745
GO:0007224
GO:0010159
GO:0072101
GO:0043401
GO:0021537
GO:0021978
GO:0035990
GO:0060438
GO:0060440
GO:0003323
GO:0072192
GO:0072193
GO:0001657
Gene3D 2.10.90.10
InterPro IPR029034
IPR001839
IPR001111
IPR015615
IPR017948
PANTHER PTHR11848
Pfam PF00019
PF00688
SMART SM00204
SUPFAM SSF57501
PROSITE PS00250
PS51362

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0061312

BMP signaling pathway involved in heart development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

NOT|involved_in

GO:1902893

regulation of pri-miRNA transcription by RNA polymerase II

PMID:18548003[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

PMID:18548003[1]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0002012)
  • occurs_in:(CL:0000359)
  • has_regulation_target:(RNAcentral:URS00000AF93C_9606)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:28124060[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000164619)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:28124060[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000199161)
  • occurs_in:(CL:0002618)|regulates_expression_of(ENSEMBL:ENSG00000199161)
  • occurs_in:(CL:1000413)
  • occurs_in:(UBERON:0001621)

Seeded From UniProt

complete

involved_in

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

PMID:28124060[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_transcription_of:(ENSEMBL:ENSG00000194717)
  • occurs_in:(CL:1000413)
  • occurs_in:(UBERON:0001621)|regulates_transcription_of(ENSEMBL:ENSG00000194717)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:28124060[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000138685)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:28124060[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_expression_of:(ENSEMBL:ENSG00000137801)
  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0061626

pharyngeal arch artery morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:1901964

positive regulation of cell proliferation involved in outflow tract morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0060976

coronary vasculature development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

occurs_in:(UBERON:0001135)

Seeded From UniProt

complete

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

occurs_in:(UBERON:0004145)

Seeded From UniProt

complete

NOT|involved_in

GO:1905072

cardiac jelly development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003277

apoptotic process involved in endocardial cushion morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003215

cardiac right ventricle morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003198

epithelial to mesenchymal transition involved in endocardial cushion formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0003197

endocardial cushion development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

occurs_in:(UBERON:0004699)

Seeded From UniProt

complete

involved_in

GO:0003184

pulmonary valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

NOT|involved_in

GO:0003150

muscular septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0003149

membranous septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0003148

outflow tract septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24906886[3]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_expression_of:(ENSEMBL:ENSG00000207613)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24906886[3]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_expression_of:(ENSEMBL:ENSG00000284499)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:24906886[3]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_expression_of:(ENSEMBL:ENSG00000164107)

Seeded From UniProt

complete

involved_in

GO:0071773

cellular response to BMP stimulus

PMID:18326817[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

enables

GO:0039706

co-receptor binding

PMID:16604073[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q7TQ32

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16604073[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18326817[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q6ZVN8

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:18326817[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045606

positive regulation of epidermal cell differentiation

PMID:18823971[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010453

regulation of cell fate commitment

PMID:18823971[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030225

macrophage differentiation

PMID:21149635[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030224

monocyte differentiation

PMID:21149635[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000137

negative regulation of cell proliferation involved in heart morphogenesis

PMID:20702560[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:15516325[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070244

negative regulation of thymocyte apoptotic process

PMID:12421925[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

PMID:18787191[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

PMID:9389648[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055020

positive regulation of cardiac muscle fiber development

PMID:20702560[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

PMID:11865031[13]

ECO:0000314

direct assay evidence used in manual assertion

P

  • happens_during:(GO:0031016)
  • occurs_in:(CL:0002079)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15516325[9]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P10451)|has_regulation_target:(UniProtKB:P05186)|has_regulation_target:(UniProtKB:Q13950)|has_regulation_target:(UniProtKB:P12643)

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:18436533[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033088

negative regulation of immature T cell proliferation in thymus

PMID:12421925[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

PMID:12421925[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

PMID:17720811[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:9389648[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:18436533[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

PMID:18436533[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:20559569[16]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q15797)

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:9389648[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003323

type B pancreatic cell development

PMID:11865031[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003139

secondary heart field specification

PMID:20702560[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003130

BMP signaling pathway involved in heart induction

PMID:20702560[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002320

lymphoid progenitor cell differentiation

PMID:12421925[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

PMID:18787191[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:17720811[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

PMID:11502704[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000007

negative regulation of metanephric comma-shaped body morphogenesis

PMID:12141440[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000005

negative regulation of metanephric S-shaped body morphogenesis

PMID:12141440[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090194

negative regulation of glomerulus development

PMID:12141440[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

PMID:17118062[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

PMID:12141440[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090184

positive regulation of kidney development

PMID:10021330[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072205

metanephric collecting duct development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0072200

negative regulation of mesenchymal cell proliferation involved in ureter development

PMID:12399320[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072193

ureter smooth muscle cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0072192

ureter epithelial cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0072125

negative regulation of glomerular mesangial cell proliferation

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072104

glomerular capillary formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

PMID:17118062[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

PMID:17118062[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072001

renal system development

PMID:17850284[24]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071893

BMP signaling pathway involved in nephric duct formation

PMID:10021330[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061155

pulmonary artery endothelial tube morphogenesis

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061151

BMP signaling pathway involved in renal system segmentation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0061149

BMP signaling pathway involved in ureter morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0061047

positive regulation of branching involved in lung morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

PMID:12631064[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048754

branching morphogenesis of an epithelial tube

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048745

smooth muscle tissue development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

PMID:17600318[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048661

positive regulation of smooth muscle cell proliferation

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048392

intermediate mesodermal cell differentiation

PMID:10021330[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10021330[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17600318[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12631064[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0007165

signal transduction

PMID:22988237[28]

ECO:0000314

P

Figure 4D shows the positive regulatory loop of the BMP4 signaling pathway

complete
CACAO 5065

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045839

negative regulation of mitotic nuclear division

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043407

negative regulation of MAP kinase activity

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

PMID:17244894[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042476

odontogenesis

PMID:11023873[29]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P13297

P

Seeded From UniProt

complete

involved_in

GO:0042326

negative regulation of phosphorylation

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042056

chemoattractant activity

PMID:12631064[26]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035993

deltoid tuberosity development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0035990

tendon cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0034504

protein localization to nucleus

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:17992660[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:16816361[31]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:17244894[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:17850284[24]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

PMID:20573232[32]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(UniProtKB:Q99717)|has_participant:(UniProtKB:Q15797)|has_participant:(UniProtKB:P84022)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

C

Seeded From UniProt

complete

involved_in

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

PMID:10706139[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

PMID:15451575[33]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0001958

endochondral ossification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P21275

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001823

mesonephros development

PMID:18437684[34]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

PMID:18305125[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:12631064[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

PMID:17600318[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

PMID:17992660[25]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070700

BMP receptor binding

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218890
UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338027
MGI:MGI:88180
MGI:MGI:88182
MGI:MGI:95689
MGI:MGI:97359
PANTHER:PTN000218063
UniProtKB:O95390
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22004
UniProtKB:P43026
UniProtKB:P61812
UniProtKB:Q6KF10
UniProtKB:Q99988

P

Seeded From UniProt

complete

involved_in

GO:0048468

cell development

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103302
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88180
PANTHER:PTN000218890
UniProtKB:P12644

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98726
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95689
MGI:MGI:95690
PANTHER:PTN000218210
RGD:2211
UniProtKB:O95393
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
MGI:MGI:1338820
MGI:MGI:88182
MGI:MGI:95684
MGI:MGI:98727
PANTHER:PTN000218063
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P08476
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22003
UniProtKB:P22004
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q96S42
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000490
MGI:MGI:103302
MGI:MGI:1338027
MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95691
MGI:MGI:98725
MGI:MGI:98726
PANTHER:PTN000218063
RGD:1305979
RGD:2211
RGD:2212
RGD:2213
RGD:2214
RGD:2912
RGD:2913
RGD:3115
RGD:3851
RGD:62074
RGD:620743
RGD:621512
RGD:69051
RGD:70491
UniProtKB:O14793
UniProtKB:O42220
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P30371
UniProtKB:P61812
UniProtKB:Q96S42
UniProtKB:Q99988
WB:WBGene00000903

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218063
UniProtKB:P61812

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218063
UniProtKB:P08476
UniProtKB:P12644

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[36]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88180
PANTHER:PTN000218890
UniProtKB:P12644

P

Seeded From UniProt

complete

enables

GO:0070700

BMP receptor binding

PMID:7811286[37]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061036

positive regulation of cartilage development

PMID:3201241[38]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060503

bud dilation involved in lung branching

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060502

epithelial cell proliferation involved in lung morphogenesis

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060438

trachea development

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060433

bronchus development

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060425

lung morphogenesis

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048286

lung alveolus development

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9187146[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045843

negative regulation of striated muscle tissue development

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045778

positive regulation of ossification

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045662

negative regulation of myoblast differentiation

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:9187146[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042306

regulation of protein import into nucleus

PMID:22529382[41]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032092

positive regulation of protein binding

PMID:23610558[42]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:17472960[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021537

telencephalon development

PMID:9187146[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009791

post-embryonic development

PMID:8674409[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:9187146[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

PMID:14749725[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

PMID:12141440[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:9187146[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0050918

positive chemotaxis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0042056

P

Seeded From UniProt

complete

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:2001012

mesenchymal cell differentiation involved in renal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:1905312

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:1901964

positive regulation of cell proliferation involved in outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072205

metanephric collecting duct development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072198

mesenchymal cell proliferation involved in ureter development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072193

ureter smooth muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072192

ureter epithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072161

mesenchymal cell differentiation involved in kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072138

mesenchymal cell proliferation involved in ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072104

glomerular capillary formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0072015

glomerular visceral epithelial cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0071363

cellular response to growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061626

pharyngeal arch artery morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061312

BMP signaling pathway involved in heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061151

BMP signaling pathway involved in renal system segmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061149

BMP signaling pathway involved in ureter morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061047

positive regulation of branching involved in lung morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0061035

regulation of cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060976

coronary vasculature development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060688

regulation of morphogenesis of a branching structure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060687

regulation of branching involved in prostate gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060686

negative regulation of prostatic bud formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060684

epithelial-mesenchymal cell signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060592

mammary gland formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060512

prostate gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060449

bud elongation involved in lung branching

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060442

branching involved in prostate gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060440

trachea formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060429

epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060363

cranial suture morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060348

bone development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060272

embryonic skeletal joint morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060235

lens induction in camera-type eye

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060197

cloacal septation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0060113

inner ear receptor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0055007

cardiac muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0051150

regulation of smooth muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0051145

smooth muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048745

smooth muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048706

embryonic skeletal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048704

embryonic skeletal system morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048701

embryonic cranial skeleton morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048663

neuron fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048660

regulation of smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048646

anatomical structure formation involved in morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048598

embryonic morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048593

camera-type eye morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0048333

mesodermal cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045778

positive regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045603

positive regulation of endothelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045597

positive regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045595

regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0045165

cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0043010

camera-type eye development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0042733

embryonic digit morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0042487

regulation of odontogenesis of dentin-containing tooth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0042475

odontogenesis of dentin-containing tooth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0035993

deltoid tuberosity development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0035990

tendon cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0035116

embryonic hindlimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0032331

negative regulation of chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030513

positive regulation of BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0021983

pituitary gland development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0021978

telencephalon regionalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0021904

dorsal/ventral neural tube patterning

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0010159

specification of animal organ position

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0009948

anterior/posterior axis specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0009888

tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0009791

post-embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

enables

GO:0008201

heparin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

F

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0007500

mesodermal cell fate determination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0007492

endoderm development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0007281

germ cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

C

Seeded From UniProt

complete

involved_in

GO:0003197

endocardial cushion development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003184

pulmonary valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003151

outflow tract morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003149

membranous septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003148

outflow tract septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0003014

renal system process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001958

endochondral ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001944

vasculature development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001759

organ induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001707

mesoderm formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001658

branching involved in ureteric bud morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001656

metanephros development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001568

blood vessel development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P21275
ensembl:ENSMUSP00000073720

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001839
InterPro:IPR017948

F

Seeded From UniProt

complete

involved_in

GO:0003279

cardiac septum development

PMID:18076106[44]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-2396399

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0891

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page
  3. 3.0 3.1 3.2 Wagh, V et al. (2014) MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther 5 75 PubMed GONUTS page
  4. 4.0 4.1 4.2 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
  5. 5.0 5.1 Babitt, JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 531-9 PubMed GONUTS page
  6. 6.0 6.1 Levine, AJ et al. (2009) GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev. Biol. 325 43-8 PubMed GONUTS page
  7. 7.0 7.1 Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Tirosh-Finkel, L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137 2989-3000 PubMed GONUTS page
  9. 9.0 9.1 Xu, WP et al. (2004) Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol. Int. 28 675-82 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page
  11. 11.0 11.1 Heinke, J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103 804-12 PubMed GONUTS page
  12. 12.0 12.1 12.2 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
  13. 13.0 13.1 Jiang, FX et al. (2002) Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J. Cell. Sci. 115 753-60 PubMed GONUTS page
  14. 14.0 14.1 14.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
  15. 15.0 15.1 Chang, J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. 282 30938-48 PubMed GONUTS page
  16. Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page
  17. Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 18.4 Martinez, G et al. (2002) BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int. J. Dev. Biol. 46 525-33 PubMed GONUTS page
  19. 19.0 19.1 19.2 Cain, JE & Bertram, JF (2006) Ureteric branching morphogenesis in BMP4 heterozygous mutant mice. J. Anat. 209 745-55 PubMed GONUTS page
  20. 20.0 20.1 20.2 20.3 Obara-Ishihara, T et al. (1999) The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 126 1103-8 PubMed GONUTS page
  21. Yu, J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129 5301-12 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 22.5 22.6 22.7 22.8 Otani, H et al. (2007) Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am. J. Physiol. Renal Physiol. 292 F1513-25 PubMed GONUTS page
  23. 23.0 23.1 23.2 23.3 23.4 23.5 23.6 Raatikainen-Ahokas, A et al. (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev. Dyn. 217 146-58 PubMed GONUTS page
  24. 24.0 24.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page
  25. 25.0 25.1 25.2 25.3 25.4 25.5 25.6 Southwood, M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol. 214 85-95 PubMed GONUTS page
  26. 26.0 26.1 26.2 26.3 Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page
  27. 27.0 27.1 27.2 Yang, X et al. (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am. J. Respir. Cell Mol. Biol. 37 598-605 PubMed GONUTS page
  28. Kang, H et al. (2012) Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J. Biol. Chem. 287 38656-64 PubMed GONUTS page
  29. Bei, M et al. (2000) BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development. Development 127 4711-8 PubMed GONUTS page
  30. 30.0 30.1 30.2 30.3 30.4 30.5 30.6 30.7 Maeda, S et al. (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23 552-63 PubMed GONUTS page
  31. Koli, K et al. (2006) Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am. J. Pathol. 169 61-71 PubMed GONUTS page
  32. Hong, SB et al. (2010) Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol. Cancer 9 160 PubMed GONUTS page
  33. Maguer-Satta, V & Rimokh, R (2004) FLRG, member of the follistatin family, a new player in hematopoiesis. Mol. Cell. Endocrinol. 225 109-18 PubMed GONUTS page
  34. Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page
  35. Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page
  36. 36.00 36.01 36.02 36.03 36.04 36.05 36.06 36.07 36.08 36.09 36.10 36.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  37. Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
  38. Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page
  39. 39.0 39.1 39.2 39.3 39.4 39.5 39.6 39.7 39.8 Bellusci, S et al. (1996) Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122 1693-702 PubMed GONUTS page
  40. 40.0 40.1 40.2 40.3 40.4 Furuta, Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124 2203-12 PubMed GONUTS page
  41. Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page
  42. Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
  43. Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page
  44. Posch, MG et al. (2008) Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects. Am. J. Med. Genet. A 146A 251-3 PubMed GONUTS page