HUMAN:BMP4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BMP4 (synonyms: BMP2B, DVR4)
Protein Name(s)	Bone morphogenetic protein 4 BMP-4 Bone morphogenetic protein 2B BMP-2B
External Links
UniProt	P12644
EMBL	M22490 U43842 BC020546 D30751
CCDS	CCDS9715.1
PIR	C37278
RefSeq	NP_001193.2 NP_570911.2 NP_570912.2 XP_005268072.1
UniGene	Hs.68879
ProteinModelPortal	P12644
SMR	P12644
BioGrid	107120
DIP	DIP-5795N
IntAct	P12644
MINT	MINT-1184353
STRING	9606.ENSP00000245451
BindingDB	P12644
ChEMBL	CHEMBL5350
PhosphoSite	P12644
DMDM	115073
PaxDb	P12644
PRIDE	P12644
DNASU	652
Ensembl	ENST00000245451 ENST00000417573 ENST00000558984 ENST00000559087
GeneID	652
KEGG	hsa:652
UCSC	uc001xal.4
CTD	652
GeneCards	GC14M054416
GeneReviews	BMP4
HGNC	HGNC:1071
HPA	CAB006863
MIM	112262 600625 607932
neXtProt	NX_P12644
Orphanet	264200 1991 139471 93100
PharmGKB	PA25381
eggNOG	NOG243555
HOGENOM	HOG000249478
HOVERGEN	HBG004860
InParanoid	P12644
KO	K04662
OMA	ATLLHMF
OrthoDB	EOG7WHH9D
PhylomeDB	P12644
TreeFam	TF351789
Reactome	REACT_150331
SignaLink	P12644
GeneWiki	Bone_morphogenetic_protein_4
GenomeRNAi	652
NextBio	2648
PRO	PR:P12644
Proteomes	UP000005640
Bgee	P12644
CleanEx	HS_BMP4
ExpressionAtlas	P12644
Genevestigator	P12644
GO	GO:0005576 GO:0005615 GO:0005578 GO:0070700 GO:0042056 GO:0005125 GO:0008201 GO:0000186 GO:0009948 GO:0002043 GO:0030509 GO:0003130 GO:0071893 GO:0061151 GO:0061149 GO:0060442 GO:0001658 GO:0048754 GO:0060433 GO:0060503 GO:0060449 GO:0003279 GO:0071363 GO:0002062 GO:0060197 GO:0007182 GO:0060363 GO:0035993 GO:0021904 GO:0048701 GO:0042733 GO:0035116 GO:0060272 GO:0003197 GO:0001958 GO:0060502 GO:0060441 GO:0060684 GO:0030218 GO:0030198 GO:0007281 GO:0072104 GO:0072015 GO:0002244 GO:0060113 GO:0048392 GO:0001822 GO:0060235 GO:0048286 GO:0060425 GO:0002320 GO:0030225 GO:0060592 GO:0072161 GO:0072198 GO:0072138 GO:0003337 GO:0007500 GO:0001823 GO:0072205 GO:0030224 GO:0043066 GO:0072097 GO:0090191 GO:0045786 GO:0060548 GO:0008285 GO:2000137 GO:0032331 GO:0050680 GO:0072125 GO:0090194 GO:0033088 GO:0043407 GO:0072200 GO:2000007 GO:2000005 GO:0045839 GO:0045662 GO:0042326 GO:0060686 GO:0045843 GO:0033085 GO:0070244 GO:0000122 GO:0045892 GO:0001843 GO:0048663 GO:0042476 GO:0042475 GO:0001649 GO:0021983 GO:0050918 GO:0043065 GO:0030513 GO:0030501 GO:0061047 GO:0055020 GO:0061036 GO:0010942 GO:0032967 GO:2000105 GO:0045603 GO:0010595 GO:0001938 GO:0045606 GO:0050679 GO:0070374 GO:0090184 GO:0045666 GO:0045778 GO:0045669 GO:0010862 GO:0032092 GO:0001934 GO:0060391 GO:0048661 GO:0045944 GO:0045893 GO:0009791 GO:0034504 GO:0061155 GO:0060687 GO:0010453 GO:0042487 GO:0060393 GO:0042306 GO:0051150 GO:0072001 GO:0003014 GO:0003139 GO:0060395 GO:0048745 GO:0007224 GO:0010159 GO:0072101 GO:0043401 GO:0021537 GO:0021978 GO:0035990 GO:0060438 GO:0060440 GO:0003323 GO:0072192 GO:0072193 GO:0001657
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
NOT\|involved_in	GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	PMID:18548003^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	PMID:18548003^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002012) occurs_in:(CL:0000359) has_regulation_target:(RNAcentral:URS00000AF93C_9606)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28124060^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000164619) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28124060^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000199161) occurs_in:(CL:0002618)\|regulates_expression_of(ENSEMBL:ENSG00000199161) occurs_in:(CL:1000413) occurs_in:(UBERON:0001621)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:28124060^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000194717) occurs_in:(CL:1000413) occurs_in:(UBERON:0001621)\|regulates_transcription_of(ENSEMBL:ENSG00000194717) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28124060^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000138685) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:28124060^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000137801) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P	has_regulation_target:(UniProtKB:P18075) occurs_in:(UBERON:0004265)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P	has_regulation_target:(UniProtKB:Q99697) occurs_in:(UBERON:0004265)\|has_regulation_target(UniProtKB:Q99985) occurs_in:(UBERON:0004265)\|has_regulation_target(UniProtKB:P61296) occurs_in:(UBERON:0004265)\|has_regulation_target(UniProtKB:O96004) occurs_in:(UBERON:0004265)	Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:1901964	positive regulation of cell proliferation involved in outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0060976	coronary vasculature development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P	occurs_in:(UBERON:0001135)	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P	occurs_in:(UBERON:0004145)	Seeded From UniProt	complete
NOT\|involved_in	GO:1905072	cardiac jelly development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003277	apoptotic process involved in endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P	occurs_in:(UBERON:0004699)	Seeded From UniProt	complete
involved_in	GO:0003184	pulmonary valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0003150	muscular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24906886^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000207613)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24906886^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000284499)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24906886^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000164107)	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	PMID:18326817^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	PMID:16604073^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q7TQ32	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16604073^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18326817^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q6ZVN8	P	has_regulation_target:(UniProtKB:P81172) occurs_in:(UBERON:0002107) part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18326817^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0045606	positive regulation of epidermal cell differentiation	PMID:18823971^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010453	regulation of cell fate commitment	PMID:18823971^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	PMID:21149635^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	PMID:21149635^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000137	negative regulation of cell proliferation involved in heart morphogenesis	PMID:20702560^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15516325^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070244	negative regulation of thymocyte apoptotic process	PMID:12421925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation	PMID:18787191^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:9389648^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055020	positive regulation of cardiac muscle fiber development	PMID:20702560^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:11865031^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0031016) occurs_in:(CL:0002079)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15516325^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10451)\|has_regulation_target:(UniProtKB:P05186)\|has_regulation_target:(UniProtKB:Q13950)\|has_regulation_target:(UniProtKB:P12643)	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:18436533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033088	negative regulation of immature T cell proliferation in thymus	PMID:12421925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033085	negative regulation of T cell differentiation in thymus	PMID:12421925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	PMID:17720811^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9389648^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18436533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:18436533^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:20559569^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15797)	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:9389648^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003323	type B pancreatic cell development	PMID:11865031^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003139	secondary heart field specification	PMID:20702560^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003130	BMP signaling pathway involved in heart induction	PMID:20702560^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002320	lymphoid progenitor cell differentiation	PMID:12421925^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:18787191^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:17720811^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:11502704^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000007	negative regulation of metanephric comma-shaped body morphogenesis	PMID:12141440^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000005	negative regulation of metanephric S-shaped body morphogenesis	PMID:12141440^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090194	negative regulation of glomerulus development	PMID:12141440^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	PMID:17118062^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	PMID:12141440^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090184	positive regulation of kidney development	PMID:10021330^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0072200	negative regulation of mesenchymal cell proliferation involved in ureter development	PMID:12399320^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072193	ureter smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0072192	ureter epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0072125	negative regulation of glomerular mesangial cell proliferation	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072104	glomerular capillary formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	PMID:17118062^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072101	specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	PMID:17118062^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072097	negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072001	renal system development	PMID:17850284^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071893	BMP signaling pathway involved in nephric duct formation	PMID:10021330^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061155	pulmonary artery endothelial tube morphogenesis	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061151	BMP signaling pathway involved in renal system segmentation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0061149	BMP signaling pathway involved in ureter morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0061047	positive regulation of branching involved in lung morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:12631064^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048745	smooth muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:17600318^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048392	intermediate mesodermal cell differentiation	PMID:10021330^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10021330^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17600318^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12631064^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0007165	signal transduction	PMID:22988237^[28]	ECO:0000314			P		Figure 4D shows the positive regulatory loop of the BMP4 signaling pathway	complete CACAO 5065
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	PMID:17244894^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	PMID:11023873^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P13297	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:12631064^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035993	deltoid tuberosity development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0035990	tendon cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:17992660^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:16816361^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:17244894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:17850284^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007182	common-partner SMAD protein phosphorylation	PMID:20573232^[32]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(UniProtKB:Q99717)\|has_participant:(UniProtKB:Q15797)\|has_participant:(UniProtKB:P84022)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	C		Seeded From UniProt	complete
involved_in	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:10706139^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	PMID:15451575^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21275	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	PMID:18437684^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:18305125^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:12631064^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:17600318^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:17992660^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218890 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88180 PANTHER:PTN000218890 UniProtKB:P12644	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95689 MGI:MGI:95690 PANTHER:PTN000218210 RGD:2211 UniProtKB:O95393 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88180 PANTHER:PTN000218890 UniProtKB:P12644	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:7811286^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	PMID:3201241^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060503	bud dilation involved in lung branching	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060438	trachea development	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060433	bronchus development	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9187146^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045843	negative regulation of striated muscle tissue development	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:9187146^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042306	regulation of protein import into nucleus	PMID:22529382^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:23610558^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:17472960^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	PMID:9187146^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	PMID:8674409^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:9187146^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:14749725^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:12141440^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9187146^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:2001012	mesenchymal cell differentiation involved in renal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:1901964	positive regulation of cell proliferation involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072198	mesenchymal cell proliferation involved in ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072193	ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072192	ureter epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072161	mesenchymal cell differentiation involved in kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072104	glomerular capillary formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0072015	glomerular visceral epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061312	BMP signaling pathway involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061151	BMP signaling pathway involved in renal system segmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061149	BMP signaling pathway involved in ureter morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061047	positive regulation of branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0061035	regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060976	coronary vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060688	regulation of morphogenesis of a branching structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060687	regulation of branching involved in prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060686	negative regulation of prostatic bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060684	epithelial-mesenchymal cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060592	mammary gland formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060512	prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060449	bud elongation involved in lung branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060442	branching involved in prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060363	cranial suture morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060272	embryonic skeletal joint morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060235	lens induction in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060197	cloacal septation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0060113	inner ear receptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0051150	regulation of smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0051145	smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048745	smooth muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048646	anatomical structure formation involved in morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048593	camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0048333	mesodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045603	positive regulation of endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0042487	regulation of odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0035993	deltoid tuberosity development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0035990	tendon cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0021978	telencephalon regionalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0010159	specification of animal organ position	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0009888	tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0007500	mesodermal cell fate determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	C		Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003184	pulmonary valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0003014	renal system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21275 ensembl:ENSMUSP00000073720	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
involved_in	GO:0003279	cardiac septum development	PMID:18076106^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2396399	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wagh, V et al. (2014) MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther 5 75 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page
↑ ^5.0 ^5.1 Babitt, JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 531-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Levine, AJ et al. (2009) GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev. Biol. 325 43-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Tirosh-Finkel, L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137 2989-3000 PubMed GONUTS page
↑ ^9.0 ^9.1 Xu, WP et al. (2004) Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol. Int. 28 675-82 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page
↑ ^11.0 ^11.1 Heinke, J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103 804-12 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
↑ ^13.0 ^13.1 Jiang, FX et al. (2002) Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J. Cell. Sci. 115 753-60 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page
↑ ^15.0 ^15.1 Chang, J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. 282 30938-48 PubMed GONUTS page
↑ Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page
↑ Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Martinez, G et al. (2002) BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int. J. Dev. Biol. 46 525-33 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Cain, JE & Bertram, JF (2006) Ureteric branching morphogenesis in BMP4 heterozygous mutant mice. J. Anat. 209 745-55 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Obara-Ishihara, T et al. (1999) The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 126 1103-8 PubMed GONUTS page
↑ Yu, J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129 5301-12 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 Otani, H et al. (2007) Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am. J. Physiol. Renal Physiol. 292 F1513-25 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Raatikainen-Ahokas, A et al. (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev. Dyn. 217 146-58 PubMed GONUTS page
↑ ^24.0 ^24.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 ^25.6 Southwood, M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol. 214 85-95 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Yang, X et al. (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am. J. Respir. Cell Mol. Biol. 37 598-605 PubMed GONUTS page
↑ Kang, H et al. (2012) Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J. Biol. Chem. 287 38656-64 PubMed GONUTS page
↑ Bei, M et al. (2000) BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development. Development 127 4711-8 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 Maeda, S et al. (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23 552-63 PubMed GONUTS page
↑ Koli, K et al. (2006) Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am. J. Pathol. 169 61-71 PubMed GONUTS page
↑ Hong, SB et al. (2010) Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol. Cancer 9 160 PubMed GONUTS page
↑ Maguer-Satta, V & Rimokh, R (2004) FLRG, member of the follistatin family, a new player in hematopoiesis. Mol. Cell. Endocrinol. 225 109-18 PubMed GONUTS page
↑ Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page
↑ Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page
↑ ^36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
↑ Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 ^39.7 ^39.8 Bellusci, S et al. (1996) Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122 1693-702 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 ^40.4 Furuta, Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124 2203-12 PubMed GONUTS page
↑ Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page
↑ Posch, MG et al. (2008) Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects. Am. J. Med. Genet. A 146A 251-3 PubMed GONUTS page

[PMID:18548003-1] 1.0 ^1.1 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page

[PMID:28124060-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Esser, JS et al. (2017) Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Thromb. Haemost. 117 734-749 PubMed GONUTS page

[PMID:24906886-3] 3.0 ^3.1 ^3.2 Wagh, V et al. (2014) MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther 5 75 PubMed GONUTS page

[PMID:18326817-4] 4.0 ^4.1 ^4.2 Xia, Y et al. (2008) Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 5195-204 PubMed GONUTS page

[PMID:16604073-5] 5.0 ^5.1 Babitt, JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 531-9 PubMed GONUTS page

[PMID:18823971-6] 6.0 ^6.1 Levine, AJ et al. (2009) GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Dev. Biol. 325 43-8 PubMed GONUTS page

[PMID:21149635-7] 7.0 ^7.1 Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page

[PMID:20702560-8] 8.0 ^8.1 ^8.2 ^8.3 Tirosh-Finkel, L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137 2989-3000 PubMed GONUTS page

[PMID:15516325-9] 9.0 ^9.1 Xu, WP et al. (2004) Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol. Int. 28 675-82 PubMed GONUTS page

[PMID:12421925-10] 10.0 ^10.1 ^10.2 ^10.3 Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page

[PMID:18787191-11] 11.0 ^11.1 Heinke, J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ. Res. 103 804-12 PubMed GONUTS page

[PMID:9389648-12] 12.0 ^12.1 ^12.2 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page

[PMID:11865031-13] 13.0 ^13.1 Jiang, FX et al. (2002) Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells. J. Cell. Sci. 115 753-60 PubMed GONUTS page

[PMID:18436533-14] 14.0 ^14.1 ^14.2 Lavery, K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J. Biol. Chem. 283 20948-58 PubMed GONUTS page

[PMID:17720811-15] 15.0 ^15.1 Chang, J et al. (2007) Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. 282 30938-48 PubMed GONUTS page

[PMID:20559569-16] Paige, SL et al. (2010) Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 5 e11134 PubMed GONUTS page

[PMID:11502704-17] Morrell, NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790-5 PubMed GONUTS page

[PMID:12141440-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Martinez, G et al. (2002) BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies. Int. J. Dev. Biol. 46 525-33 PubMed GONUTS page

[PMID:17118062-19] 19.0 ^19.1 ^19.2 Cain, JE & Bertram, JF (2006) Ureteric branching morphogenesis in BMP4 heterozygous mutant mice. J. Anat. 209 745-55 PubMed GONUTS page

[PMID:10021330-20] 20.0 ^20.1 ^20.2 ^20.3 Obara-Ishihara, T et al. (1999) The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 126 1103-8 PubMed GONUTS page

[PMID:12399320-21] Yu, J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129 5301-12 PubMed GONUTS page

[PMID:17244894-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 Otani, H et al. (2007) Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am. J. Physiol. Renal Physiol. 292 F1513-25 PubMed GONUTS page

[PMID:10706139-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Raatikainen-Ahokas, A et al. (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev. Dyn. 217 146-58 PubMed GONUTS page

[PMID:17850284-24] 24.0 ^24.1 Jenkins, D et al. (2007) Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J. Anat. 211 620-9 PubMed GONUTS page

[PMID:17992660-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 ^25.6 Southwood, M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J. Pathol. 214 85-95 PubMed GONUTS page

[PMID:12631064-26] 26.0 ^26.1 ^26.2 ^26.3 Miyazaki, Y et al. (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63 835-44 PubMed GONUTS page

[PMID:17600318-27] 27.0 ^27.1 ^27.2 Yang, X et al. (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am. J. Respir. Cell Mol. Biol. 37 598-605 PubMed GONUTS page

[PMID:22988237-28] Kang, H et al. (2012) Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J. Biol. Chem. 287 38656-64 PubMed GONUTS page

[PMID:11023873-29] Bei, M et al. (2000) BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development. Development 127 4711-8 PubMed GONUTS page

[PMID:14749725-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 ^30.6 ^30.7 Maeda, S et al. (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23 552-63 PubMed GONUTS page

[PMID:16816361-31] Koli, K et al. (2006) Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am. J. Pathol. 169 61-71 PubMed GONUTS page

[PMID:20573232-32] Hong, SB et al. (2010) Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Mol. Cancer 9 160 PubMed GONUTS page

[PMID:15451575-33] Maguer-Satta, V & Rimokh, R (2004) FLRG, member of the follistatin family, a new player in hematopoiesis. Mol. Cell. Endocrinol. 225 109-18 PubMed GONUTS page

[PMID:18437684-34] Carev, D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol. Histopathol. 23 853-62 PubMed GONUTS page

[PMID:18305125-35] Weber, S et al. (2008) SIX2 and BMP4 mutations associate with anomalous kidney development. J. Am. Soc. Nephrol. 19 891-903 PubMed GONUTS page

[PMID:21873635-36] 36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7811286-37] Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

[PMID:3201241-38] Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page

[PMID:8674409-39] 39.0 ^39.1 ^39.2 ^39.3 ^39.4 ^39.5 ^39.6 ^39.7 ^39.8 Bellusci, S et al. (1996) Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122 1693-702 PubMed GONUTS page

[PMID:9187146-40] 40.0 ^40.1 ^40.2 ^40.3 ^40.4 Furuta, Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124 2203-12 PubMed GONUTS page

[PMID:22529382-41] Home, P et al. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. U.S.A. 109 7362-7 PubMed GONUTS page

[PMID:23610558-42] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:17472960-43] Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page

[PMID:18076106-44] Posch, MG et al. (2008) Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects. Am. J. Med. Genet. A 146A 251-3 PubMed GONUTS page

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HUMAN:BMP4

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