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PMID:10021330

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Citation

Obara-Ishihara, T, Kuhlman, J, Niswander, L and Herzlinger, D (1999) The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 126:1103-8

Abstract

The nephric duct is the first epithelial tubule to differentiate from intermediate mesoderm that is essential for all further urogenital development. In this study we identify the domain of intermediate mesoderm that gives rise to the nephric duct and demonstrate that the surface ectoderm is required for its differentiation. Removal of the surface ectoderm resulted in decreased levels of Sim-1 and Pax-2 mRNA expression in mesenchymal nephric duct progenitors, and caused inhibition of nephric duct formation and subsequent kidney development. The surface ectoderm expresses BMP-4 and we show that it is required for the maintenance of high-level BMP-4 expression in lateral plate mesoderm. Addition of a BMP-4-coated bead to embryos lacking the surface ectoderm restored normal levels of Sim-1 and Pax-2 mRNA expression in nephric duct progenitors, nephric duct formation and the initiation of nephrogenesis. Thus, BMP-4 signaling can substitute for the surface ectoderm in supporting nephric duct morphogenesis. Collectively, these data suggest that inductive interactions between the surface ectoderm, lateral mesoderm and intermediate mesoderm are essential for nephric duct formation and the initiation of urogenital development.

Links

PubMed

Keywords

Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/metabolism; Cell Lineage; Chick Embryo; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Ectoderm; Embryonic Induction; In Situ Hybridization; Kidney Tubules/embryology; Mesoderm; PAX2 Transcription Factor; RNA, Messenger/isolation & purification; Repressor Proteins/biosynthesis; Repressor Proteins/genetics; Signal Transduction; Transcription Factors/biosynthesis; Transcription Factors/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:E1C5G3

involved_in

GO:0001822: kidney development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:E1C5G3

involved_in

GO:0072179: nephric duct formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0048392: intermediate mesodermal cell differentiation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0072179: nephric duct formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:BMP4

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q9PTX1

involved_in

GO:0001822: kidney development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CHICK:Q9PTX1

involved_in

GO:0072179: nephric duct formation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0048392: intermediate mesodermal cell differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0071893: BMP signaling pathway involved in nephric duct formation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0090184: positive regulation of kidney development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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