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PMID:11502704

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Citation

Morrell, NW, Yang, X, Upton, PD, Jourdan, KB, Morgan, N, Sheares, KK and Trembath, RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104:790-5

Abstract

Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-beta (TGF-beta) superfamily, underlie many cases of familial and sporadic primary pulmonary hypertension (PPH). We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members.

Links

PubMed

Keywords

Activin Receptors; Adult; Binding, Competitive/drug effects; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins/pharmacology; Cell Division/drug effects; Cells, Cultured; Cross-Linking Reagents/pharmacology; DNA/biosynthesis; DNA/genetics; DNA Mutational Analysis; Female; Gene Expression Profiling; Humans; Hypertension, Pulmonary/pathology; Hypertension, Pulmonary/physiopathology; Male; Middle Aged; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/pathology; Muscle, Smooth, Vascular/physiopathology; Protein-Serine-Threonine Kinases/biosynthesis; Protein-Serine-Threonine Kinases/genetics; Pulmonary Artery; RNA, Messenger/biosynthesis; Receptors, Transforming Growth Factor beta/biosynthesis; Receptors, Transforming Growth Factor beta/genetics; Signal Transduction/drug effects; Thymidine/pharmacokinetics; Transforming Growth Factor beta/pharmacology; Transforming Growth Factor beta1

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BMP2

involved_in

GO:0045786: negative regulation of cell cycle

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:TGFB1

involved_in

GO:0045786: negative regulation of cell cycle

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMPR2

involved_in

GO:0042127: regulation of cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP7

involved_in

GO:0045786: negative regulation of cell cycle

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0045786: negative regulation of cell cycle

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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