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PMID:12631064

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Citation

Miyazaki, Y, Oshima, K, Fogo, A and Ichikawa, I (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int. 63:835-44

Abstract

We have suggested that bone morphogenetic protein 4 (BMP4), acting on the Wolffian duct and ureter epithelium, determines the budding site of the ureter by locally antagonizing ubiquitous inductive signal(s) from the metanephric mesenchyme. In the present study, we examine the effect of BMP4 on the development of metanephric and periureteral mesenchymal cells, which express the BMP type I receptor gene, Bmpr1a (Alk3).

Links

PubMed Online version:10.1046/j.1523-1755.2003.00834.x

Keywords

Animals; Apoptosis/physiology; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/metabolism; Cell Movement/physiology; Female; Kidney/cytology; Kidney/embryology; Kidney/physiology; Male; Mesoderm/cytology; Mice; Mice, Mutant Strains; Muscle, Smooth/cytology; Muscle, Smooth/embryology; Muscle, Smooth/physiology; Organ Culture Techniques; Stromal Cells/cytology; Ureter/cytology; Ureter/embryology; Ureter/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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