PMID:10706139

Citation	Raatikainen-Ahokas, A, Hytönen, M, Tenhunen, A, Sainio, K and Sariola, H (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev. Dyn. 217:146-58
Abstract	Bone morphogenetic protein-4 (BMP4), a member of the transforming growth factor-beta (TGF-beta) family, regulates several developmental processes during animal development. We have now studied the effects of BMP-4 in the metanephric kidney differentiation by using organ culture technique. Human recombinant BMP-4 diminishes the number of ureteric branches and changes the branching pattern. Our data suggest that BMP-4 affects the ureteric branching indirectly via interfering with the differentiation of the nephrogenic mesenchyme. The clear positional preference of the defects to posterior mesenchyme might reflect an early anterior-posterior patterning of the metanephric mesenchyme. The smooth muscle alpha-actin expressing cell population around the ureteric stalk, highly expressing Bmp-4 mRNA, is also expanded in kidneys treated with BMP-4. Thus, BMP-4 may be a physiological regulator of the development of the periureteric smooth muscle layer and ureteric elongation.
Links	PubMed Online version:<146::AID-DVDY2>3.0.CO;2-I 10.1002/(SICI)1097-0177(200002)217:2<146::AID-DVDY2>3.0.CO;2-I
Keywords	Animals; Axis; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/pharmacology; Humans; Kidney/drug effects; Kidney/embryology; Mesoderm/drug effects; Mice; Mice, Inbred CBA; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Recombinant Proteins/pharmacology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:BMP4	involved_in	GO:0048661: positive regulation of smooth muscle cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0048754: branching morphogenesis of an epithelial tube	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0043065: positive regulation of apoptotic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0003337: mesenchymal to epithelial transition involved in metanephros morphogenesis	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0072101: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:BMP4	involved_in	GO:0072097: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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