GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:12399320

From GONUTS
Jump to: navigation, search
Citation

Yu, J, Carroll, TJ and McMahon, AP (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129:5301-12

Abstract

Signaling by the ureteric bud epithelium is essential for survival, proliferation and differentiation of the metanephric mesenchyme during kidney development. Most studies that have addressed ureteric signaling have focused on the proximal, branching, ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter -- the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic hedgehog receptor and a downstream target gene of the signaling pathway in the mesenchyme surrounding the distal collecting ducts and the ureter suggests that sonic hedgehog acts as a paracrine signal. In vivo and in vitro analyses demonstrate that sonic hedgehog promotes mesenchymal cell proliferation, regulates the timing of differentiation of smooth muscle progenitor cells, and sets the pattern of mesenchymal differentiation through its dose-dependent inhibition of smooth muscle formation. In addition, we also show that bone morphogenetic protein 4 is a downstream target gene of sonic hedgehog signaling in kidney stroma and ureteral mesenchyme, but does not mediate the effects of sonic hedgehog in the control of mesenchymal proliferation.

Links

PubMed

Keywords

Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/metabolism; Cell Differentiation/physiology; Cell Division/genetics; Hedgehog Proteins; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Hydronephrosis/embryology; Hydronephrosis/genetics; Integrases/genetics; Kidney/abnormalities; Kidney/embryology; Kidney Diseases/embryology; Mesoderm/cytology; Mesoderm/metabolism; Mice; Mice, Transgenic; Muscle, Smooth/cytology; Muscle, Smooth/pathology; Mutation; Signal Transduction; Trans-Activators/genetics; Trans-Activators/metabolism; Urothelium/embryology; Urothelium/metabolism; Viral Proteins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SHH

involved_in

GO:0001656: metanephros development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:0045893: positive regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:0072136: metanephric mesenchymal cell proliferation involved in metanephros development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:2000062: negative regulation of ureter smooth muscle cell differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:2000063: positive regulation of ureter smooth muscle cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:2000357: negative regulation of kidney smooth muscle cell differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:2000358: positive regulation of kidney smooth muscle cell differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

involved_in

GO:2000729: positive regulation of mesenchymal cell proliferation involved in ureter development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:BMP4

involved_in

GO:0072200: negative regulation of mesenchymal cell proliferation involved in ureter development

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.