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PMID:7811286

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Citation

Yamaji, N, Celeste, AJ, Thies, RS, Song, JJ, Bernier, SM, Goltzman, D, Lyons, KM, Nove, J, Rosen, V and Wozney, JM (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205:1944-51

Abstract

Bone morphogenetic proteins (BMPs) are a class of related growth and differentiation factors within the TGF-beta superfamily of proteins which are known to induce cartilage and bone formation in adult animals and to be involved in many inductive events throughout embryonic development. Here we describe the molecular cloning and characterization of a mammalian receptor, CFK-43a, which specifically binds BMP-2 and BMP-4. This molecule is a member of the serine/threonine kinase receptor family which includes receptors for other TGF-beta superfamily members. CFK-43a binds other BMP family members with lower affinity, but does not bind TGF-beta. During embryogenesis, in situ hybridization analysis indicates that CFK-43a mRNA is localized in developing skeletal tissues in a complementary fashion to the transcripts for its ligands.

Links

PubMed Online version:10.1006/bbrc.1994.2898

Keywords

Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Proteins; Cell Line; Cloning, Molecular; DNA Primers/genetics; DNA, Complementary/genetics; Extremities/embryology; Gene Expression Regulation, Developmental; Humans; In Situ Hybridization; Kinetics; Mice; Molecular Sequence Data; Protein Binding; Protein-Serine-Threonine Kinases; Proteins/genetics; Proteins/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Receptors, Growth Factor/genetics; Receptors, Growth Factor/metabolism; Receptors, Transforming Growth Factor beta

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:BMP2

enables

GO:0070700: BMP receptor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:BMP3

enables

GO:0070700: BMP receptor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:BMP6

enables

GO:0046982: protein heterodimerization activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:BMP6

enables

GO:0070700: BMP receptor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:BMP3

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P12645

F

Seeded From UniProt

complete

HUMAN:BMP5

enables

GO:0070700: BMP receptor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:BMP4

enables

GO:0070700: BMP receptor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:BMP5

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P22003

F

Seeded From UniProt

complete

MOUSE:BMP7

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P22004

F

Seeded From UniProt

complete

MOUSE:BMP4

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P12644

F

Seeded From UniProt

complete

MOUSE:BMP2

enables

GO:0046982: protein heterodimerization activity

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P12643

F

Seeded From UniProt

complete

MOUSE:BMP2

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P12643

F

Seeded From UniProt

complete

MOUSE:BMP6

enables

GO:0046982: protein heterodimerization activity

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P22004

F

Seeded From UniProt

complete

MOUSE:BMP6

enables

GO:0070700: BMP receptor binding

ECO:0000266: sequence orthology evidence used in manual assertion

UniProtKB:P22004

F

Seeded From UniProt

complete


See also

References

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