DANRE:F1QX69

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000113959)
External Links
UniProt	F1QX69
EMBL	CT033825
ProteinModelPortal	F1QX69
Ensembl	ENSDART00000139933
ZFIN	ZDB-GENE-030219-1
GeneTree	ENSGT00740000114888
InParanoid	F1QX69
OMA	FDHIGWD
OrthoDB	EOG7DFXD1
TreeFam	TF351786
Proteomes	UP000000437
GO	GO:0005576 GO:0035462 GO:0003140 GO:0007368 GO:0035469 GO:0035050 GO:0040007 GO:0003146 GO:0001947 GO:0048368 GO:2000223
Gene3D	2.10.90.10
InterPro	IPR029034 IPR002405 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PRINTS	PR00669
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0071910	determination of liver left/right asymmetry	PMID:24212328^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-150730-1	P	Seeded From UniProt	complete
involved_in	GO:0071907	determination of digestive tract left/right asymmetry	PMID:24212328^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-150730-1	P	Seeded From UniProt	complete
involved_in	GO:0061371	determination of heart left/right asymmetry	PMID:25100766^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-150831-15	P	Seeded From UniProt	complete
involved_in	GO:0048368	lateral mesoderm development	PMID:18985756^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0035469	determination of pancreatic left/right asymmetry	PMID:24212328^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-150730-1	P	Seeded From UniProt	complete
involved_in	GO:0035469	determination of pancreatic left/right asymmetry	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0035469	determination of pancreatic left/right asymmetry	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0035462	determination of left/right asymmetry in diencephalon	PMID:24212328^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-150730-1	P	Seeded From UniProt	complete
involved_in	GO:0035462	determination of left/right asymmetry in diencephalon	PMID:19363156^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0035462	determination of left/right asymmetry in diencephalon	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0035462	determination of left/right asymmetry in diencephalon	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:18267096^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1 ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18784369^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090225-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18267096^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1 ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17678853^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17592620^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:16207761^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:14576439^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:18784369^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090225-2	P	Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:15084459^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1 ZFIN:ZDB-MRPHLNO-060718-1	P	Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-2	P	Seeded From UniProt	complete
involved_in	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:12702646^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060112-1	P	Seeded From UniProt	complete
enables	GO:0070698	type I activin receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218276 UniProtKB:Q96S42	F	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95689 MGI:MGI:95690 PANTHER:PTN000218210 RGD:2211 UniProtKB:O95393 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Long, S et al. (2003) The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development 130 2303-16 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Noël, ES et al. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat Commun 4 2754 PubMed GONUTS page
↑ Kalogirou, S et al. (2014) Intracardiac flow dynamics regulate atrioventricular valve morphogenesis. Cardiovasc. Res. 104 49-60 PubMed GONUTS page
↑ Wang, X & Yost, HJ (2008) Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development. Dev. Dyn. 237 3640-7 PubMed GONUTS page
↑ Roussigné, M et al. (2009) Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development 136 1549-57 PubMed GONUTS page
↑ ^6.0 ^6.1 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
↑ ^7.0 ^7.1 Baker, K et al. (2008) Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proc. Natl. Acad. Sci. U.S.A. 105 13924-9 PubMed GONUTS page
↑ Carl, M et al. (2007) Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron 55 393-405 PubMed GONUTS page
↑ Kuan, YS et al. (2007) Selective asymmetry in a conserved forebrain to midbrain projection. J. Exp. Zool. B Mol. Dev. Evol. 308 669-78 PubMed GONUTS page
↑ Gamse, JT et al. (2005) Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development 132 4869-81 PubMed GONUTS page
↑ Horne-Badovinac, S et al. (2003) A cellular framework for gut-looping morphogenesis in zebrafish. Science 302 662-5 PubMed GONUTS page
↑ Hashimoto, H et al. (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development 131 1741-53 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12702646-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Long, S et al. (2003) The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development 130 2303-16 PubMed GONUTS page

[PMID:24212328-2] 2.0 ^2.1 ^2.2 ^2.3 Noël, ES et al. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nat Commun 4 2754 PubMed GONUTS page

[PMID:25100766-3] Kalogirou, S et al. (2014) Intracardiac flow dynamics regulate atrioventricular valve morphogenesis. Cardiovasc. Res. 104 49-60 PubMed GONUTS page

[PMID:18985756-4] Wang, X & Yost, HJ (2008) Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development. Dev. Dyn. 237 3640-7 PubMed GONUTS page

[PMID:19363156-5] Roussigné, M et al. (2009) Nodal signalling imposes left-right asymmetry upon neurogenesis in the habenular nuclei. Development 136 1549-57 PubMed GONUTS page

[PMID:18267096-6] 6.0 ^6.1 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page

[PMID:18784369-7] 7.0 ^7.1 Baker, K et al. (2008) Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. Proc. Natl. Acad. Sci. U.S.A. 105 13924-9 PubMed GONUTS page

[PMID:17678853-8] Carl, M et al. (2007) Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries. Neuron 55 393-405 PubMed GONUTS page

[PMID:17592620-9] Kuan, YS et al. (2007) Selective asymmetry in a conserved forebrain to midbrain projection. J. Exp. Zool. B Mol. Dev. Evol. 308 669-78 PubMed GONUTS page

[PMID:16207761-10] Gamse, JT et al. (2005) Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development 132 4869-81 PubMed GONUTS page

[PMID:14576439-11] Horne-Badovinac, S et al. (2003) A cellular framework for gut-looping morphogenesis in zebrafish. Science 302 662-5 PubMed GONUTS page

[PMID:15084459-12] Hashimoto, H et al. (2004) The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development 131 1741-53 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 ^13.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:F1QX69

Contents

Annotations

Notes

References

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