GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:14576439
Citation |
Horne-Badovinac, S, Rebagliati, M and Stainier, DY (2003) A cellular framework for gut-looping morphogenesis in zebrafish. Science 302:662-5 |
---|---|
Abstract |
Many vertebrate organs adopt asymmetric positions with respect to the midline, but little is known about the cellular changes and tissue movements that occur downstream of left-right gene expression to produce this asymmetry. Here, we provide evidence that the looping of the zebrafish gut results from the asymmetric migration of the neighboring lateral plate mesoderm (LPM). Mutations that disrupt the epithelial structure of the LPM perturb this asymmetric migration and inhibit gut looping. Asymmetric LPM migration still occurs when the endoderm is ablated from the gut-looping region, suggesting that the LPM can autonomously provide a motive force for gut displacement. Finally, reducing left-sided Nodal activity randomizes the pattern of LPM migration and gut looping. These results reveal a cellular framework for the regulation of organ laterality by asymmetrically expressed genes. |
Links |
PubMed Online version:10.1126/science.1085397 |
Keywords |
Animals; Body Patterning; Cell Movement; Cues; Endoderm/physiology; Gene Expression Regulation, Developmental; Guanylate Kinase; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Intestines/embryology; Isoenzymes; Mesoderm/cytology; Mesoderm/physiology; Morphogenesis; Mutation; Nuclear Proteins; Nucleoside-Phosphate Kinase/genetics; Nucleoside-Phosphate Kinase/metabolism; Oligonucleotides, Antisense; Phenotype; Protein Kinase C/genetics; Protein Kinase C/physiology; Transcription Factors/genetics; Transcription Factors/physiology; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology |
edit table |
Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
edit table |
See also
References
See Help:References for how to manage references in GONUTS.