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MOUSE:BMP5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Bmp5 (synonyms: Bmp-5) | |
| Protein Name(s) | Bone morphogenetic protein 5
BMP-5 | |
| External Links | ||
| UniProt | P49003 | |
| EMBL | L41145 AK033362 AC079245 AC144940 | |
| CCDS | CCDS23348.1 | |
| PIR | I49542 | |
| RefSeq | NP_031581.2 | |
| UniGene | Mm.428950 | |
| ProteinModelPortal | P49003 | |
| SMR | P49003 | |
| STRING | 10090.ENSMUSP00000012281 | |
| PhosphoSite | P49003 | |
| PRIDE | P49003 | |
| Ensembl | ENSMUST00000012281 | |
| GeneID | 12160 | |
| KEGG | mmu:12160 | |
| UCSC | uc009qsu.1 | |
| CTD | 653 | |
| MGI | MGI:88181 | |
| eggNOG | NOG272883 | |
| GeneTree | ENSGT00760000118883 | |
| HOVERGEN | HBG004860 | |
| InParanoid | P49003 | |
| KO | K04663 | |
| OMA | FRIYKDQ | |
| OrthoDB | EOG7J9VPQ | |
| TreeFam | TF316134 | |
| ChiTaRS | Bmp5 | |
| NextBio | 280507 | |
| PRO | PR:P49003 | |
| Proteomes | UP000000589 | |
| Bgee | P49003 | |
| CleanEx | MM_BMP5 | |
| ExpressionAtlas | P49003 | |
| Genevestigator | P49003 | |
| GO | GO:0005615 GO:0031988 GO:0070700 GO:0051216 GO:0040007 GO:0030539 GO:0032348 GO:0008285 GO:2000065 GO:0043569 GO:0001503 GO:0007389 GO:1900006 GO:2000105 GO:0050679 GO:0010862 GO:0045944 GO:0001501 GO:0003323 | |
| Gene3D | 2.10.90.10 | |
| InterPro | IPR029034 IPR001839 IPR001111 IPR015615 IPR017948 | |
| PANTHER | PTHR11848 | |
| Pfam | PF00019 PF00688 | |
| SMART | SM00204 | |
| SUPFAM | SSF57501 | |
| PROSITE | PS00250 PS51362 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0003272 |
endocardial cushion formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060411 |
cardiac septum morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061384 |
heart trabecula morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003344 |
pericardium morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048738 |
cardiac muscle tissue development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905069 |
allantois development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060710 |
chorio-allantoic fusion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030902 |
hindbrain development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021502 |
neural fold elevation formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060037 |
pharyngeal system development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070700 |
BMP receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000932177 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060395 |
SMAD protein signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1338027 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048468 |
cell development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103302 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043408 |
regulation of MAPK cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107335 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98726 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030509 |
BMP signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103302 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107335 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000490 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005160 |
transforming growth factor beta receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98725 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000218063 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000065 |
negative regulation of cortisol biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900006 |
positive regulation of dendrite development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0097065 |
anterior head development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2679550 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070700 |
BMP receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043583 |
ear development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2679550 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043569 |
negative regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032348 |
negative regulation of aldosterone biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031982 |
vesicle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305979 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030539 |
male genitalia development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88182 |
P |
results_in_development_of:(EMAPA:29769) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0010894 |
negative regulation of steroid biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007389 |
pattern specification process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1858106 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305979 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0003323 |
type B pancreatic cell development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001501 |
skeletal system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857400 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000065 |
negative regulation of cortisol biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900006 |
positive regulation of dendrite development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070700 |
BMP receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050679 |
positive regulation of epithelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043569 |
negative regulation of insulin-like growth factor receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032348 |
negative regulation of aldosterone biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010894 |
negative regulation of steroid biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003323 |
type B pancreatic cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P22003 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001503 |
ossification |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Solloway, MJ & Robertson, EJ (1999) Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126 1753-68 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Palmer, K et al. (2016) Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev. Biol. 415 216-227 PubMed GONUTS page
- ↑ Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
- ↑ Solloway, MJ et al. (1998) Mice lacking Bmp6 function. Dev. Genet. 22 321-39 PubMed GONUTS page
- ↑ 6.0 6.1 Kingsley, DM et al. (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 71 399-410 PubMed GONUTS page
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- GO:0010894 ! negative regulation of steroid biosynthetic process
- GO:2000065 ! negative regulation of cortisol biosynthetic process
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0032348 ! negative regulation of aldosterone biosynthetic process
- GO:0043569 ! negative regulation of insulin-like growth factor receptor signaling pathway
- GO:0021502 ! neural fold elevation formation
o
p
- GO:0007389 ! pattern specification process
- GO:0003344 ! pericardium morphogenesis
- GO:0060037 ! pharyngeal system development
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:1900006 ! positive regulation of dendrite development
- GO:0050679 ! positive regulation of epithelial cell proliferation
- GO:0008284 ! positive regulation of cell population proliferation
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