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DANRE:DVR1
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | dvr1 (synonyms: dvr-1, vg1) | |
| Protein Name(s) | Protein DVR-1 | |
| External Links | ||
| UniProt | P35621 | |
| EMBL | U00931 | |
| RefSeq | NP_571023.1 | |
| UniGene | Dr.307 | |
| ProteinModelPortal | P35621 | |
| SMR | P35621 | |
| STRING | 7955.ENSDARP00000055378 | |
| PRIDE | P35621 | |
| Ensembl | ENSDART00000055379 | |
| GeneID | 30125 | |
| KEGG | dre:30125 | |
| CTD | 9573 | |
| ZFIN | ZDB-GENE-980526-389 | |
| eggNOG | NOG255568 | |
| GeneTree | ENSGT00760000118883 | |
| HOGENOM | HOG000249476 | |
| HOVERGEN | HBG004860 | |
| InParanoid | P35621 | |
| KO | K05495 | |
| OMA | KDVGWQD | |
| OrthoDB | EOG71CFMF | |
| TreeFam | TF351789 | |
| Reactome | REACT_208506 | |
| NextBio | 20806604 | |
| Proteomes | UP000000437 | |
| Bgee | P35621 | |
| GO | GO:0005576 GO:0040007 GO:0051781 | |
| Gene3D | 2.10.90.10 | |
| InterPro | IPR029034 IPR001839 IPR001111 IPR015615 IPR017948 | |
| PANTHER | PTHR11848 | |
| Pfam | PF00019 PF00688 | |
| SMART | SM00204 | |
| SUPFAM | SSF57501 | |
| PROSITE | PS00250 PS51362 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1904136 |
regulation of convergent extension involved in notochord morphogenesis |
ECO:0000316 |
|
P |
In Figure 2 G-I, injection of Setdb2 morpholino will result in a wider and shorter notochord, however, when Dvr1 morpholino is co-injected with Setdb2 morpholino, the effects of setdb2 morpholino are reversed. |
complete | ||||
| GO:1904103 |
regulation of convergent extension involved in gastrulation |
ECO:0000316 |
|
P |
In Figure 2 G-I injection of Setdb2 morpholino will result in a wider and shorter notochord, however, when Dvr1 morpholino is co-injected with Setdb2 morpholino, the effects of setdb2 morpholino are reversed. |
complete | ||||
| GO:1904086 |
regulation of epiboly involved in gastrulation with mouth forming second |
ECO:0000315 |
P |
In Figure 3 A-F, varying amounts of dvr1 mRNA are injected into embryos and compared to a control embryo. With larger amounts of dvr1 mRNA injection there are higher percentages of delayed epiboly, leading to the conclusion that dvr1 is involved in epiboly. |
complete | |||||
| GO:1904130 |
regulation of convergent extension involved in neural plate elongation |
ECO:0000315 |
P |
In figure 3 J and K, embryos injected with 10pg of DVR1 mRNA show broader neural plates than embryos not injected. This suggests involvement in neural plate morphogenesis. |
complete | |||||
| GO:1904127 |
regulation of convergent extension involved in somitogenesis |
ECO:0000315 |
P |
In figure 3 L and M, embryos injected with 10pg of DVR1 mRNA show wider and slightly shorter somites than embryos not injected. This suggests involvement in somitogenesis. |
complete | |||||
|
involved_in |
GO:1904086 |
regulation of epiboly involved in gastrulation with mouth forming second |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900145 |
regulation of nodal signaling pathway involved in determination of left/right asymmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-140117-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060972 |
left/right pattern formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-100312-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-030131-7093 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-171103-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-100312-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048666 |
neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-100312-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048382 |
mesendoderm development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181004-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038092 |
nodal signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181004-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038092 |
nodal signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181002-11 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-990415-256 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-990415-181 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030509 |
BMP signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181002-11 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009798 |
axis specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181002-8 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-100312-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001707 |
mesoderm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181002-11 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001706 |
endoderm formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-181002-11 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060395 |
SMAD protein signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1338027 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048468 |
cell development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103302 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043408 |
regulation of MAPK cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107335 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98726 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030509 |
BMP signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88177 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107335 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000490 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005160 |
transforming growth factor beta receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98725 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000218063 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Du, TT et al. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev. Biol. 392 233-44 PubMed GONUTS page
- ↑ Peterson, AG et al. (2013) Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish. Dev. Biol. 382 198-208 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Pelliccia, JL et al. (2017) Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. Elife 6 PubMed GONUTS page
- ↑ 4.0 4.1 Li, X et al. (2012) Arsenic impairs embryo development via down-regulating Dvr1 expression in zebrafish. Toxicol. Lett. 212 161-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Montague, TG & Schier, AF (2017) Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm. Elife 6 PubMed GONUTS page
- ↑ Bisgrove, BW et al. (2017) Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish. Elife 6 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
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- GO:0010469 ! regulation of signaling receptor activity
- GO:1904103 ! regulation of convergent extension involved in gastrulation
- GO:0042981 ! regulation of apoptotic process
- GO:0043408 ! regulation of MAPK cascade
- GO:1904127 ! regulation of convergent extension involved in somitogenesis
- GO:1904130 ! regulation of convergent extension involved in neural plate elongation
- GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second
- GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis
