MOUSE:SMAD4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad4 (synonyms: Dpc4, Madh4)
Protein Name(s)	Mothers against decapentaplegic homolog 4 MAD homolog 4 Mothers against DPP homolog 4 Deletion target in pancreatic carcinoma 4 homolog SMAD family member 4 SMAD 4 Smad4
External Links
UniProt	P97471
EMBL	U79748 CH466528 BC046584 AK004804
CCDS	CCDS29337.1
RefSeq	NP_032566.2
UniGene	Mm.100399
PDB	3QSV
PDBsum	3QSV
ProteinModelPortal	P97471
SMR	P97471
BioGrid	201277
DIP	DIP-29718N
IntAct	P97471
MINT	MINT-261841
PhosphoSite	P97471
MaxQB	P97471
PaxDb	P97471
PRIDE	P97471
Ensembl	ENSMUST00000025393 ENSMUST00000114939
GeneID	17128
KEGG	mmu:17128
UCSC	uc008fou.1
CTD	4089
MGI	MGI:894293
eggNOG	NOG286923
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286019
HOVERGEN	HBG053353
InParanoid	P97471
KO	K04501
OMA	PTEGHSI
OrthoDB	EOG712TW5
TreeFam	TF314923
Reactome	REACT_202264 REACT_203510 REACT_203903 REACT_216222 REACT_216258 REACT_216792 REACT_220505 REACT_220566 REACT_220645
ChiTaRS	Smad4
EvolutionaryTrace	P97471
NextBio	291316
PRO	PR:P97471
Proteomes	UP000000589
Bgee	P97471
CleanEx	MM_SMAD4
ExpressionAtlas	P97471
Genevestigator	P97471
GO	GO:0032444 GO:0005813 GO:0005737 GO:0000790 GO:0005634 GO:0071141 GO:0005667 GO:0003682 GO:0005518 GO:0000987 GO:0003677 GO:0046872 GO:0046982 GO:0042803 GO:0000977 GO:0001085 GO:0001076 GO:0003700 GO:0030616 GO:0009952 GO:0036302 GO:0003190 GO:0007411 GO:0030509 GO:0003360 GO:0001658 GO:0003279 GO:0008283 GO:0048589 GO:0060956 GO:0007492 GO:0042118 GO:0003198 GO:0048859 GO:0007369 GO:0001702 GO:0001701 GO:0001822 GO:0007498 GO:0072133 GO:0060548 GO:0030308 GO:0008285 GO:0042177 GO:0045892 GO:0072134 GO:0014033 GO:0048663 GO:0060021 GO:0030513 GO:0003251 GO:0010718 GO:0010862 GO:0060391 GO:0045944 GO:0045893 GO:0030511 GO:0051098 GO:0042127 GO:0051797 GO:0006357 GO:0032909 GO:0001666 GO:0048733 GO:0007183 GO:0060395 GO:0032525 GO:0048729 GO:0006366 GO:0007179
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030509	BMP signaling pathway	PMID:11788714^[1]	ECO:0000314			P		It is shown by figure 3 through a direct assay that Smad4 binds to a promoter for the homeodomain Dlx-3 that is responsive to signaling by BMP-2.	complete CACAO 6367
	GO:0007398	ectoderm development	PMID:11788714^[1]	ECO:0000314			P		It is shown by figure 3 through a direct assay that Smad4 binds to a promoter for Dlx-3, which is known to regulate patterning in the embyronic ectoderm.	complete CACAO 6368
	GO:0042733	embryonic digit morphogenesis	PMID:23034633^[2]	ECO:0000315			P		As shown in figures 1 and 2, inactivation of Smad4 leads to a lack of development in the skeletal portion of embryonic digits.	complete CACAO 7501
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:23426367^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000065610) occurs_in:(CL:0002618) part_of:(GO:1903844)	Seeded From UniProt	complete
involved_in	GO:1905305	negative regulation of cardiac myofibril assembly	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001133) has_regulation_target:(UniProtKB:Q91Z83)\|occurs_in(UBERON:0001133) has_regulation_target:(UniProtKB:P05125)\|occurs_in(UBERON:0001133) has_regulation_target:(UniProtKB:P40753)	Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:17628518^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q63961	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	PMID:16151019^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9JHI9) occurs_in:(UBERON:0002114)\|has_regulation_target(UniProtKB:P49282) occurs_in:(UBERON:0002114)\|has_regulation_target(UniProtKB:Q925G2) occurs_in:(UBERON:0002114)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9EQ21) occurs_in:(UBERON:0002107)\|has_regulation_target(UniProtKB:Q9EQ21) part_of:(GO:0070102)\|has_regulation_target(UniProtKB:Q9EQ21) part_of:(GO:0030509) occurs_in:(CL:0000182)\|has_regulation_target(UniProtKB:Q9EQ21) part_of:(GO:0007179) occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:16330325^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000617	positive regulation of histone H3-K9 acetylation	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:16330325^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18539898^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:O35253)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q9EQ21)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:P20067)\|occurs_in(UBERON:0002107) has_regulation_target:(UniProtKB:Q99NA2)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18539898^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) has_regulation_target:(UniProtKB:P20722)	Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:23034633^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19366691^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19366691^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:19366691^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21330551^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21330551^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
involved_in	GO:0060956	endocardial cell differentiation	PMID:21330551^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:14691138^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0062009	secondary palate development	PMID:14691138^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21330551^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P41136)	Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:21330551^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:21330551^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q08369	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:14691138^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:14691138^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14691138^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14691138^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003279	cardiac septum development	PMID:21330551^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q08369	P		Seeded From UniProt	complete
involved_in	GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis	PMID:21330551^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:21330551^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003190	atrioventricular valve formation	PMID:21330551^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q08369	P		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:21330551^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43694	F		Seeded From UniProt	complete
involved_in	GO:0072134	nephrogenic mesenchyme morphogenesis	PMID:15342483^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072133	metanephric mesenchyme morphogenesis	PMID:15342483^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:15342483^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9288972^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70056	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072520	seminiferous tubule development	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071559	response to transforming growth factor beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070207	protein homotrimerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061040	female gonad morphogenesis	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060065	uterus development	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051797	regulation of hair follicle development	PMID:18692037^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393	P	regulates_o_results_in_development_of:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051098	regulation of binding	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048859	formation of anatomical boundary	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048733	sebaceous gland development	PMID:18692037^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393	P	results_in_development_of:(EMAPA:35754)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048729	tissue morphogenesis	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:17698011^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393,MGI:MGI:2386570	P	has_participant:(EMAPA:16797) results_in_commitment_to:(CL:0000111)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21724602^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046881	positive regulation of follicle-stimulating hormone secretion	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046881	positive regulation of follicle-stimulating hormone secretion	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18986983^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1321394	P	has_regulation_target:(MGI:MGI:1341800)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17568773^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347465 MGI:MGI:98725	P	has_regulation_target:(MGI:MGI:1351322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17159989^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051 MGI:MGI:1201674 MGI:MGI:1314872 MGI:MGI:98727	P	has_regulation_target:(MGI:MGI:3616404)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18692037^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393	P	regulates_o_occurs_in:(EMAPA:17525) has_regulation_target:(MGI:MGI:2661061)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9702197^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19251704^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96429)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16556916^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98495)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15282343^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0043199	sulfate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21724602^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:11809702^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039 MGI:MGI:97798	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:11809702^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039 MGI:MGI:97788	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10708962^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10708962^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857697	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033686	positive regulation of luteinizing hormone secretion	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033686	positive regulation of luteinizing hormone secretion	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032525	somite rostral/caudal axis specification	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
enables	GO:0031005	filamin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	F		Seeded From UniProt	complete
enables	GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014033	neural crest cell differentiation	PMID:19793887^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15215210^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691,MGI:MGI:2656539,MGI:MGI:2668393	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008585	female gonad development	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9506519^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	regulates_o_occurs_in:(EMAPA:19252)\|regulates_o_occurs_in:(EMAPA:32834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15925496^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104903 MGI:MGI:88177	P	regulates_o_occurs_in:(EMAPA:28477)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11197776^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:10626800^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	regulates_o_occurs_in:(EMAPA:17021)\|regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:21300867^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393,MGI:MGI:4459942	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007369	gastrulation	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007338	single fertilization	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007183	SMAD protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:18212064^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051 MGI:MGI:98725 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:18212064^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108051 MGI:MGI:98725 MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:12270938^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18692037^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	PMID:14559231^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08121 UniProtKB:Q01149 UniProtKB:Q3U962	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16556916^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:98495)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14633973^[38]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12943993^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18212064^[34]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:87951)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15657445^[40]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:87951)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15459107^[41]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14764653^[42]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95582)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12270938^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	F		Seeded From UniProt	complete
contributes_to	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003360	brainstem development	PMID:21300867^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386393,MGI:MGI:4459942	P	results_in_development_of:(EMAPA:32790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:15342483^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3624262,MGI:MGI:3626290	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001702	gastrulation with mouth forming second	PMID:15215210^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857691,MGI:MGI:2656539,MGI:MGI:2668393	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9420335^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858049	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:15925496^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104903 MGI:MGI:88177	P	has_participant:(EMAPA:28477)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3033	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:24739304^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1349428	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21724602^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13485	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24739304^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386394	P		Seeded From UniProt	complete
involved_in	GO:0071559	response to transforming growth factor beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0043199	sulfate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
enables	GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13485 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R274 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R274 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R274 ensembl:ENSP00000341551	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625492	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page
↑ ^2.0 ^2.1 Bénazet, JD et al. (2012) Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development 139 4250-60 PubMed GONUTS page
↑ Wang, J et al. (2013) Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium. J. Biol. Chem. 288 10418-26 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Wang, J et al. (2005) Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ. Res. 97 821-8 PubMed GONUTS page
↑ Mancini, ML et al. (2007) Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev. Biol. 308 520-33 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Wang, RH et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 399-409 PubMed GONUTS page
↑ ^7.0 ^7.1 Kautz, L et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112 1503-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hsu, LJ et al. (2009) Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J. Biol. Chem. 284 16049-59 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Moskowitz, IP et al. (2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc. Natl. Acad. Sci. U.S.A. 108 4006-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Nawshad, A & Hay, ED (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163 1291-301 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Oxburgh, L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131 4593-605 PubMed GONUTS page
↑ Chen, X et al. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389 85-9 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 ^13.14 ^13.15 Fortin, J et al. (2014) Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J. 28 3396-410 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page
↑ ^15.0 ^15.1 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Sirard, C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12 107-19 PubMed GONUTS page
↑ Hodge, LK et al. (2007) Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55 572-86 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page
↑ Sharff, KA et al. (2009) Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J. Biol. Chem. 284 649-59 PubMed GONUTS page
↑ Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page
↑ Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page
↑ Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page
↑ Lin, EA et al. (2009) miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J. Biol. Chem. 284 11326-35 PubMed GONUTS page
↑ ^24.0 ^24.1 Yang, L et al. (2006) Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133 1575-85 PubMed GONUTS page
↑ ^25.0 ^25.1 Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page
↑ ^26.0 ^26.1 Taketo, MM & Takaku, K () Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev. 11 147-57 PubMed GONUTS page
↑ Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page
↑ ^28.0 ^28.1 Chu, GC et al. (2004) Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131 3501-12 PubMed GONUTS page
↑ Takaku, K et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92 645-56 PubMed GONUTS page
↑ ^30.0 ^30.1 Hartwig, S et al. (2005) Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech. Dev. 122 928-38 PubMed GONUTS page
↑ Taketo, MM & Takaku, K (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum. Cell 13 85-95 PubMed GONUTS page
↑ Takaku, K et al. (1999) Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res. 59 6113-7 PubMed GONUTS page
↑ ^33.0 ^33.1 da Silva, S et al. (2011) Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A. 108 3395-400 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Wilkinson, DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol. Cell. Biol. 28 1988-98 PubMed GONUTS page
↑ ^35.0 ^35.1 Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page
↑ Xiao, C et al. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17 2933-49 PubMed GONUTS page
↑ Ellsworth, BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol. Cell. Endocrinol. 206 93-111 PubMed GONUTS page
↑ Wilkinson, DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol. Cell. Biol. 25 1200-12 PubMed GONUTS page
↑ Brugger, SM et al. (2004) A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development 131 5153-65 PubMed GONUTS page
↑ Bailey, JS et al. (2004) Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol. Endocrinol. 18 1158-70 PubMed GONUTS page

[PMID:11788714-1] 1.0 ^1.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page

[PMID:23034633-2] 2.0 ^2.1 Bénazet, JD et al. (2012) Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development 139 4250-60 PubMed GONUTS page

[PMID:23426367-3] Wang, J et al. (2013) Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium. J. Biol. Chem. 288 10418-26 PubMed GONUTS page

[PMID:16151019-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Wang, J et al. (2005) Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ. Res. 97 821-8 PubMed GONUTS page

[PMID:17628518-5] Mancini, ML et al. (2007) Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev. Biol. 308 520-33 PubMed GONUTS page

[PMID:16330325-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Wang, RH et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 399-409 PubMed GONUTS page

[PMID:18539898-7] 7.0 ^7.1 Kautz, L et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112 1503-9 PubMed GONUTS page

[PMID:19366691-8] 8.0 ^8.1 ^8.2 Hsu, LJ et al. (2009) Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J. Biol. Chem. 284 16049-59 PubMed GONUTS page

[PMID:21330551-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Moskowitz, IP et al. (2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc. Natl. Acad. Sci. U.S.A. 108 4006-11 PubMed GONUTS page

[PMID:14691138-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Nawshad, A & Hay, ED (2003) TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163 1291-301 PubMed GONUTS page

[PMID:15342483-11] 11.0 ^11.1 ^11.2 ^11.3 Oxburgh, L et al. (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131 4593-605 PubMed GONUTS page

[PMID:9288972-12] Chen, X et al. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389 85-9 PubMed GONUTS page

[PMID:24739304-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 ^13.11 ^13.12 ^13.13 ^13.14 ^13.15 Fortin, J et al. (2014) Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J. 28 3396-410 PubMed GONUTS page

[PMID:18692037-14] 14.0 ^14.1 ^14.2 ^14.3 Owens, P et al. (2008) Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev. Biol. 322 156-66 PubMed GONUTS page

[PMID:15282343-15] 15.0 ^15.1 Subramanian, SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol. Biol. Cell 15 4532-43 PubMed GONUTS page

[PMID:9420335-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Sirard, C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12 107-19 PubMed GONUTS page

[PMID:17698011-17] Hodge, LK et al. (2007) Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55 572-86 PubMed GONUTS page

[PMID:21724602-18] 18.0 ^18.1 ^18.2 Baburajendran, N et al. (2011) Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res. 39 8213-22 PubMed GONUTS page

[PMID:18986983-19] Sharff, KA et al. (2009) Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J. Biol. Chem. 284 649-59 PubMed GONUTS page

[PMID:17568773-20] Izzi, L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 26 3132-43 PubMed GONUTS page

[PMID:17159989-21] Zhang, J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat. Neurosci. 10 77-86 PubMed GONUTS page

[PMID:9702197-22] Labbé, E et al. (1998) Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2 109-20 PubMed GONUTS page

[PMID:19251704-23] Lin, EA et al. (2009) miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1. J. Biol. Chem. 284 11326-35 PubMed GONUTS page

[PMID:16556916-24] 24.0 ^24.1 Yang, L et al. (2006) Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133 1575-85 PubMed GONUTS page

[PMID:11809702-25] 25.0 ^25.1 Seno, H et al. (2002) Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 62 506-11 PubMed GONUTS page

[PMID:10708962-26] 26.0 ^26.1 Taketo, MM & Takaku, K () Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev. 11 147-57 PubMed GONUTS page

[PMID:19793887-27] Morikawa, Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136 3575-84 PubMed GONUTS page

[PMID:15215210-28] 28.0 ^28.1 Chu, GC et al. (2004) Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131 3501-12 PubMed GONUTS page

[PMID:9506519-29] Takaku, K et al. (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92 645-56 PubMed GONUTS page

[PMID:15925496-30] 30.0 ^30.1 Hartwig, S et al. (2005) Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech. Dev. 122 928-38 PubMed GONUTS page

[PMID:11197776-31] Taketo, MM & Takaku, K (2000) Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Hum. Cell 13 85-95 PubMed GONUTS page

[PMID:10626800-32] Takaku, K et al. (1999) Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice. Cancer Res. 59 6113-7 PubMed GONUTS page

[PMID:21300867-33] 33.0 ^33.1 da Silva, S et al. (2011) Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. Proc. Natl. Acad. Sci. U.S.A. 108 3395-400 PubMed GONUTS page

[PMID:18212064-34] 34.0 ^34.1 ^34.2 Wilkinson, DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol. Cell. Biol. 28 1988-98 PubMed GONUTS page

[PMID:12270938-35] 35.0 ^35.1 Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page

[PMID:19796622-36] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:14559231-37] Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page

[PMID:14633973-38] Xiao, C et al. (2003) Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17 2933-49 PubMed GONUTS page

[PMID:12943993-39] Ellsworth, BS et al. (2003) The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol. Cell. Endocrinol. 206 93-111 PubMed GONUTS page

[PMID:15657445-40] Wilkinson, DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol. Cell. Biol. 25 1200-12 PubMed GONUTS page

[PMID:15459107-41] Brugger, SM et al. (2004) A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development 131 5153-65 PubMed GONUTS page

[PMID:14764653-42] Bailey, JS et al. (2004) Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol. Endocrinol. 18 1158-70 PubMed GONUTS page

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MOUSE:SMAD4

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