CAEEL:DAF7

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	daf-7
Protein Name(s)	Dauer larva development regulatory growth factor daf-7 Abnormal dauer formation protein 7
External Links
UniProt	P92172
EMBL	U72883 U72884 FO080194
PIR	T25451
RefSeq	NP_497265.1
UniGene	Cel.19630
PDB	1ZJX
PDBsum	1ZJX
ProteinModelPortal	P92172
BioGrid	40506
STRING	6239.B0412.2
EPD	P92172
PaxDb	P92172
PeptideAtlas	P92172
EnsemblMetazoa	B0412.2
GeneID	175237
KEGG	cel:CELE_B0412.2
UCSC	B0412.2
CTD	175237
WormBase	B0412.2
eggNOG	KOG3900 ENOG410XT8Z
GeneTree	ENSGT00910000143982
InParanoid	P92172
KO	K05497
OMA	FMEVKIS
OrthoDB	EOG091G0OSN
PhylomeDB	P92172
Reactome	R-CEL-114608 R-CEL-2129379 R-CEL-2173789 R-CEL-3000170 R-CEL-8941855 R-CEL-8941858
SignaLink	P92172
PRO	PR:P92172
Proteomes	UP000001940
Bgee	WBGene00000903
GO	GO:0005615 GO:0005125 GO:0008083 GO:0005160 GO:0030509 GO:0048468 GO:0071321 GO:0071444 GO:0043053 GO:0040024 GO:0050829 GO:0016045 GO:0032490 GO:0008340 GO:0030536 GO:0061067 GO:0010629 GO:0010628 GO:0010862 GO:0045944 GO:0042981 GO:0061065 GO:1903998 GO:0043408 GO:0043051 GO:0009266 GO:0060395 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR016319 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019
PIRSF	PIRSF001787
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005615	extracellular space	PMID:26218657^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:17900898^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071444	cellular response to pheromone	PMID:27799655^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q95QI7	P		Seeded From UniProt	complete
involved_in	GO:0009266	response to temperature stimulus	PMID:8893028^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0061065)	Seeded From UniProt	complete
involved_in	GO:0071321	cellular response to cGMP	PMID:19489741^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:O16850	P	causally_upstream_of:(GO:0010628)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19489741^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:O16850	P	has_regulation_target:(UniProtKB:O18696) happens_during:(GO:0071321)	Seeded From UniProt	complete
involved_in	GO:0061065	regulation of dauer larval development	PMID:1732156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061065	regulation of dauer larval development	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EFF5	P		Seeded From UniProt	complete
involved_in	GO:0030536	larval feeding behavior	PMID:18316030^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O76360	P		Seeded From UniProt	complete
involved_in	GO:1903998	regulation of eating behavior	PMID:18316030^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O76360	P		Seeded From UniProt	complete
involved_in	GO:0030536	larval feeding behavior	PMID:18316030^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005666)	Seeded From UniProt	complete
involved_in	GO:1903998	regulation of eating behavior	PMID:18316030^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005666)	Seeded From UniProt	complete
involved_in	GO:0061065	regulation of dauer larval development	PMID:8893028^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005666)	Seeded From UniProt	complete
involved_in	GO:0061067	negative regulation of dauer larval development	PMID:6583682^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088559	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25303524^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O17532,UniProtKB:Q95QI7,UniProtKB:Q95QI8	P		Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	PMID:25303524^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(WBbt:0005667)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25303524^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P51875	P		Seeded From UniProt	complete
involved_in	GO:0043053	dauer entry	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5ED37	P		Seeded From UniProt	complete
involved_in	GO:0043053	dauer entry	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P46873	P		Seeded From UniProt	complete
involved_in	GO:0043053	dauer entry	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q22830	P		Seeded From UniProt	complete
involved_in	GO:0043053	dauer entry	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P90757	P		Seeded From UniProt	complete
involved_in	GO:0043053	dauer entry	PMID:1732156^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q19542	P		Seeded From UniProt	complete
involved_in	GO:0032490	detection of molecule of bacterial origin	PMID:25303524^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:19489741^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0071321) has_regulation_target:(UniProtKB:Q23430)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19489741^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q23430)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25303524^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25303524^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8910282^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04202	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:8910282^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04202	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8910282^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04202	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9834189^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00143951	P		Seeded From UniProt	complete
involved_in	GO:0043051	regulation of pharyngeal pumping	PMID:18680713^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00143951	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:15840165^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00004860	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:15840165^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00002210	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:11677050^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000915	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:11677050^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000907	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:10887089^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000900	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:10625546^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000910	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:10887089^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00143951	P		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:10625546^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00143951	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016319	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yoshina, S & Mitani, S (2015) Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. PLoS ONE 10 e0133966 PubMed GONUTS page
↑ Shaw, WM et al. (2007) The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr. Biol. 17 1635-45 PubMed GONUTS page
↑ Greene, JS et al. (2016) Balancing selection shapes density-dependent foraging behaviour. Nature 539 254-258 PubMed GONUTS page
↑ ^4.0 ^4.1 Schackwitz, WS et al. (1996) Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17 719-28 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Hahm, JH et al. (2009) Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. Aging Cell 8 473-83 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Vowels, JJ & Thomas, JH (1992) Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130 105-23 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 You, YJ et al. (2008) Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. Cell Metab. 7 249-57 PubMed GONUTS page
↑ Golden, JW & Riddle, DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl. Acad. Sci. U.S.A. 81 819-23 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ren, P et al. (1996) Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Science 274 1389-91 PubMed GONUTS page
↑ Thatcher, JD et al. (1999) The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126 97-107 PubMed GONUTS page
↑ Greer, ER et al. (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 8 118-31 PubMed GONUTS page
↑ ^13.0 ^13.1 Maduzia, LL et al. (2005) C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation. BMC Dev. Biol. 5 8 PubMed GONUTS page
↑ ^14.0 ^14.1 Murakami, M et al. (2001) DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. Mech. Dev. 109 27-35 PubMed GONUTS page
↑ ^15.0 ^15.1 Gunther, CV et al. (2000) A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development. Development 127 3337-47 PubMed GONUTS page
↑ ^16.0 ^16.1 Inoue, T & Thomas, JH (2000) Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev. Biol. 217 192-204 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26218657-1] Yoshina, S & Mitani, S (2015) Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. PLoS ONE 10 e0133966 PubMed GONUTS page

[PMID:17900898-2] Shaw, WM et al. (2007) The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr. Biol. 17 1635-45 PubMed GONUTS page

[PMID:27799655-3] Greene, JS et al. (2016) Balancing selection shapes density-dependent foraging behaviour. Nature 539 254-258 PubMed GONUTS page

[PMID:8893028-4] 4.0 ^4.1 Schackwitz, WS et al. (1996) Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Neuron 17 719-28 PubMed GONUTS page

[PMID:19489741-5] 5.0 ^5.1 ^5.2 ^5.3 Hahm, JH et al. (2009) Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans. Aging Cell 8 473-83 PubMed GONUTS page

[PMID:1732156-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Vowels, JJ & Thomas, JH (1992) Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130 105-23 PubMed GONUTS page

[PMID:18316030-7] 7.0 ^7.1 ^7.2 ^7.3 You, YJ et al. (2008) Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. Cell Metab. 7 249-57 PubMed GONUTS page

[PMID:6583682-8] Golden, JW & Riddle, DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl. Acad. Sci. U.S.A. 81 819-23 PubMed GONUTS page

[PMID:25303524-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Meisel, JD et al. (2014) Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans. Cell 159 267-80 PubMed GONUTS page

[PMID:8910282-10] 10.0 ^10.1 ^10.2 Ren, P et al. (1996) Control of C. elegans larval development by neuronal expression of a TGF-beta homolog. Science 274 1389-91 PubMed GONUTS page

[PMID:9834189-11] Thatcher, JD et al. (1999) The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126 97-107 PubMed GONUTS page

[PMID:18680713-12] Greer, ER et al. (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab. 8 118-31 PubMed GONUTS page

[PMID:15840165-13] 13.0 ^13.1 Maduzia, LL et al. (2005) C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation. BMC Dev. Biol. 5 8 PubMed GONUTS page

[PMID:11677050-14] 14.0 ^14.1 Murakami, M et al. (2001) DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. Mech. Dev. 109 27-35 PubMed GONUTS page

[PMID:10887089-15] 15.0 ^15.1 Gunther, CV et al. (2000) A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development. Development 127 3337-47 PubMed GONUTS page

[PMID:10625546-16] 16.0 ^16.1 Inoue, T & Thomas, JH (2000) Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Dev. Biol. 217 192-204 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:DAF7

Contents

Annotations

Notes

References

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