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PMID:11677050
| Citation |
Murakami, M, Koga, M and Ohshima, Y (2001) DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. Mech. Dev. 109:27-35 |
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| Abstract |
In C. elegans development, unfavorable growth conditions lead a larva to an arrested and enduring form called a dauer. To elucidate components upstream of DAF-7/TGF-beta in this control pathway, we isolated a mutant that was defective in daf-7 promoter::gfp reporter expression and showed an arrested (dauer-constitutive) phenotype. It has a new mutation in the daf-11 gene encoding a transmembrane guanylyl cyclase. We show that daf-11 gene and a related gene daf-21 act upstream of daf-7, and cilium-related genes che-2 and che-3 are placed between daf-11 and daf-7, in the genetic pathway controlling dauer formation. Expression of daf-11 cDNA by cell specific promoters suggests that daf-11 acts cell autonomously in ASI chemosensory neurons for daf-7 expression. |
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| Keywords |
Alleles; Animals; Artificial Gene Fusion; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Guanylate Cyclase/genetics; Guanylate Cyclase/metabolism; Helminth Proteins/genetics; Larva/growth & development; Luminescent Proteins/genetics; Mutagenesis; Neurons; Phenotype; Promoter Regions, Genetic; Transforming Growth Factor beta/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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