RAT:TGFB3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tgfb3 (synonyms: Tgf-b3)
Protein Name(s)	Transforming growth factor beta-3 TGF-beta-3 Latency-associated peptide LAP
External Links
UniProt	Q07258
EMBL	U03491 BC092195 X71903
PIR	A55706
RefSeq	NP_037306.1
UniGene	Rn.7018
ProteinModelPortal	Q07258
SMR	Q07258
STRING	10116.ENSRNOP00000013516
PaxDb	Q07258
PRIDE	Q07258
Ensembl	ENSRNOT00000013516
GeneID	25717
KEGG	rno:25717
UCSC	RGD:3851
CTD	7043
RGD	3851
eggNOG	NOG269146
GeneTree	ENSGT00760000119112
HOGENOM	HOG000290198
HOVERGEN	HBG074115
InParanoid	Q07258
KO	K13377
OMA	PEPSVMT
OrthoDB	EOG70GMFT
PhylomeDB	Q07258
TreeFam	TF351793
Reactome	REACT_198592 REACT_198757
NextBio	607801
PRO	PR:Q07258
Proteomes	UP000002494
Genevestigator	Q07258
GO	GO:0009986 GO:0005737 GO:0031012 GO:0005615 GO:0043025 GO:0005634 GO:0030141 GO:0030315 GO:0046982 GO:0005160 GO:0000187 GO:0007568 GO:0016049 GO:0045216 GO:0070483 GO:0048565 GO:0048702 GO:0060325 GO:0007565 GO:0060364 GO:0001701 GO:0048839 GO:0048286 GO:0030324 GO:0030879 GO:0008285 GO:0008156 GO:0010936 GO:0043524 GO:0030512 GO:0043932 GO:0060021 GO:0043065 GO:0030501 GO:0051781 GO:0032967 GO:0045740 GO:0010718 GO:0051491 GO:0010862 GO:0050714 GO:0060391 GO:0045944 GO:0045601 GO:0030856 GO:0050678 GO:0043627 GO:0001666 GO:0034616 GO:0032570 GO:0007435 GO:0007184 GO:0007179 GO:0042060
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR016319 IPR015615 IPR017948 IPR015618
PANTHER	PTHR11848
Pfam	PF00019 PF00688
PIRSF	PIRSF001787
PRINTS	PR01423 PR01426
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0062009	secondary palate development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17125	P	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	C	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600-2	F	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0043932	ossification involved in bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600-2	F	Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	F	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	F	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	F	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0070483	detection of hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10600	P	Seeded From UniProt	complete
involved_in	GO:0060364	frontal suture morphogenesis	PMID:12416537^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:16479080^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048702	embryonic neurocranium morphogenesis	PMID:11002343^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	PMID:12815632^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18406405^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:14605008^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16532270^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11002343^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:15214860^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:18205704^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	PMID:16217485^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:12071374^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:7852342^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:9281452^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:15214860^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16479080^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:11002343^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:12051734^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:15927076^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9281452^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9281452^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16891311^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:14697406^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:14605008^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218722 UniProtKB:P01137 UniProtKB:P10600 UniProtKB:P61812	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A5YM40 ensembl:ENSP00000238682	C	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A5YM40 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A5YM40 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
involved_in	GO:1905075	positive regulation of tight junction disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0070483	detection of hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	C	Seeded From UniProt	complete
involved_in	GO:0060325	face morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0043932	ossification involved in bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
enables	GO:0034714	type III transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0010936	negative regulation of macrophage cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0007435	salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10600 ensembl:ENSP00000238682	P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015618	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016319	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	PMID:12183510^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045601	regulation of endothelial cell differentiation	PMID:12183510^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030856	regulation of epithelial cell differentiation	PMID:12183510^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:7852342^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Adab, K et al. (2002) Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Orthod Craniofac Res 5 227-37 PubMed GONUTS page
↑ ^2.0 ^2.1 Kim, HJ et al. (2006) Expression of TGFbeta family in the developing internal ear of rat embryos. J. Korean Med. Sci. 21 136-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Opperman, LA et al. (2000) Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Dev. Dyn. 219 237-47 PubMed GONUTS page
↑ de Andrade Sá, ER et al. (2003) Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. Dev. Dyn. 227 450-7 PubMed GONUTS page
↑ Anjaneyulu, M et al. (2008) Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Exp. Neurol. 211 469-79 PubMed GONUTS page
↑ ^6.0 ^6.1 Chaturvedi, K & Sarkar, DK (2004) Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells. Endocrinology 145 706-15 PubMed GONUTS page
↑ Konrad, L et al. (2006) Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis 11 739-48 PubMed GONUTS page
↑ ^8.0 ^8.1 Fèvre-Montange, M et al. (2004) Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. J. Neuroendocrinol. 16 571-6 PubMed GONUTS page
↑ Wagner, W & Wehrmann, M () Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. J. Cell. Mol. Med. 11 1342-51 PubMed GONUTS page
↑ Fong, KD et al. (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116 1393-404; discussion 1405-6 PubMed GONUTS page
↑ Opperman, LA et al. (2002) Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration. Orthod Craniofac Res 5 5-16 PubMed GONUTS page
↑ ^12.0 ^12.1 Wang, J et al. (1995) Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. J. Biol. Chem. 270 2722-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Li, JM & Brooks, G (1997) Differential protein expression and subcellular distribution of TGFbeta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy. J. Mol. Cell. Cardiol. 29 2213-24 PubMed GONUTS page
↑ Zhao, H et al. (2002) Transforming growth factor-beta(s) and their receptors in aging rat prostate. Biochem. Biophys. Res. Commun. 294 464-9 PubMed GONUTS page
↑ Shooner, C et al. (2005) TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod. Biol. Endocrinol. 3 20 PubMed GONUTS page
↑ Liu, G et al. (2006) Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. J. Biol. Chem. 281 29479-90 PubMed GONUTS page
↑ Gong, LM et al. (2004) Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia. Life Sci. 74 1225-41 PubMed GONUTS page
↑ ^18.00 ^18.01 ^18.02 ^18.03 ^18.04 ^18.05 ^18.06 ^18.07 ^18.08 ^18.09 ^18.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Vicencio, AG et al. (2002) Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J. Appl. Physiol. 93 1123-30 PubMed GONUTS page

[PMID:12416537-1] Adab, K et al. (2002) Tgf-beta1, Tgf-beta2, Tgf-beta3 and Msx2 expression is elevated during frontonasal suture morphogenesis and during active postnatal facial growth. Orthod Craniofac Res 5 227-37 PubMed GONUTS page

[PMID:16479080-2] 2.0 ^2.1 Kim, HJ et al. (2006) Expression of TGFbeta family in the developing internal ear of rat embryos. J. Korean Med. Sci. 21 136-42 PubMed GONUTS page

[PMID:11002343-3] 3.0 ^3.1 ^3.2 Opperman, LA et al. (2000) Transforming growth factor-beta 2 and TGF-beta 3 regulate fetal rat cranial suture morphogenesis by regulating rates of cell proliferation and apoptosis. Dev. Dyn. 219 237-47 PubMed GONUTS page

[PMID:12815632-4] Andrade Sá, ER et al. (2003) Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. Dev. Dyn. 227 450-7 PubMed GONUTS page

[PMID:18406405-5] Anjaneyulu, M et al. (2008) Transforming growth factor-beta induces cellular injury in experimental diabetic neuropathy. Exp. Neurol. 211 469-79 PubMed GONUTS page

[PMID:14605008-6] 6.0 ^6.1 Chaturvedi, K & Sarkar, DK (2004) Involvement of protein kinase C-dependent mitogen-activated protein kinase p44/42 signaling pathway for cross-talk between estradiol and transforming growth factor-beta3 in increasing basic fibroblast growth factor in folliculostellate cells. Endocrinology 145 706-15 PubMed GONUTS page

[PMID:16532270-7] Konrad, L et al. (2006) Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis 11 739-48 PubMed GONUTS page

[PMID:15214860-8] 8.0 ^8.1 Fèvre-Montange, M et al. (2004) Localization of transforming growth factors, TGFbeta1 and TGFbeta3, in hypothalamic magnocellular neurones and the neurohypophysis. J. Neuroendocrinol. 16 571-6 PubMed GONUTS page

[PMID:18205704-9] Wagner, W & Wehrmann, M () Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin. J. Cell. Mol. Med. 11 1342-51 PubMed GONUTS page

[PMID:16217485-10] Fong, KD et al. (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116 1393-404; discussion 1405-6 PubMed GONUTS page

[PMID:12071374-11] Opperman, LA et al. (2002) Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration. Orthod Craniofac Res 5 5-16 PubMed GONUTS page

[PMID:7852342-12] 12.0 ^12.1 Wang, J et al. (1995) Cloning and expression of glucocorticoid-induced genes in fetal rat lung fibroblasts. Transforming growth factor-beta 3. J. Biol. Chem. 270 2722-8 PubMed GONUTS page

[PMID:9281452-13] 13.0 ^13.1 ^13.2 Li, JM & Brooks, G (1997) Differential protein expression and subcellular distribution of TGFbeta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy. J. Mol. Cell. Cardiol. 29 2213-24 PubMed GONUTS page

[PMID:12051734-14] Zhao, H et al. (2002) Transforming growth factor-beta(s) and their receptors in aging rat prostate. Biochem. Biophys. Res. Commun. 294 464-9 PubMed GONUTS page

[PMID:15927076-15] Shooner, C et al. (2005) TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod. Biol. Endocrinol. 3 20 PubMed GONUTS page

[PMID:16891311-16] Liu, G et al. (2006) Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. J. Biol. Chem. 281 29479-90 PubMed GONUTS page

[PMID:14697406-17] Gong, LM et al. (2004) Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia. Life Sci. 74 1225-41 PubMed GONUTS page

[PMID:21873635-18] 18.00 ^18.01 ^18.02 ^18.03 ^18.04 ^18.05 ^18.06 ^18.07 ^18.08 ^18.09 ^18.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12183510-19] 19.0 ^19.1 ^19.2 Vicencio, AG et al. (2002) Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J. Appl. Physiol. 93 1123-30 PubMed GONUTS page

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RAT:TGFB3

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