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PMID:15927076

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Citation

Shooner, C, Caron, PL, Fréchette-Frigon, G, Leblanc, V, Déry, MC and Asselin, E (2005) TGF-beta expression during rat pregnancy and activity on decidual cell survival. Reprod. Biol. Endocrinol. 3:20

Abstract

During early rat pregnancy, trophoblast of the tiny embryo joins with the endometrium and epithelial cells undergo apoptosis. Near the end of pregnancy, regression of the decidua basalis (DB) is also observed (from day 14 to 20). However, little is known about the intra-cellular and molecular mechanisms involved in apoptosis regulation in the uterus during pregnancy. The objective of the present study was to investigate the presence and the developmental expression of transforming growth factor-beta isoforms (TGF-beta well known differentiation factor) in the rat endometrium throughout pregnancy and its action in vitro using cultured endometrial stromal cells.

Links

PubMed PMC1166574 Online version:10.1186/1477-7827-3-20

Keywords

Animals; Antibodies, Monoclonal/metabolism; Apoptosis/physiology; Cell Survival; Cells, Cultured; Decidua/cytology; Endometrium/metabolism; Female; Gene Expression Regulation; Phosphorylation; Pregnancy/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Rats; Rats, Sprague-Dawley; Smad2 Protein/metabolism; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta/physiology; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; X-Linked Inhibitor of Apoptosis Protein/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:TGFB2

involved_in

GO:0007565: female pregnancy

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TGFB3

involved_in

GO:0007565: female pregnancy

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TGFB1

involved_in

GO:0007565: female pregnancy

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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