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PMID:16217485

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Citation

Fong, KD, Trindade, MC, Wang, Z, Nacamuli, RP, Pham, H, Fang, TD, Song, HM, Smith, RL, Longaker, MT and Chang, J (2005) Microarray analysis of mechanical shear effects on flexor tendon cells. Plast. Reconstr. Surg. 116:1393-404; discussion 1405-6

Abstract

Adhesion formation after flexor tendon repair remains a clinical problem. Early postoperative motion after tendon repair has been demonstrated to reduce adhesion formation while increasing tendon strength. The authors hypothesized that during mobilization, tendon cells experience mechanical shear forces that alter their biology in a fashion that reduces scar formation but also activates key genes involved in tendon healing.

Links

PubMed

Keywords

Animals; Blotting, Northern; Cells, Cultured; Collagen/metabolism; Gene Expression Profiling; Male; Mice; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Tendons/cytology; Tissue Adhesions/physiopathology; Wound Healing/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:TGFB2

involved_in

GO:0034616: response to laminar fluid shear stress

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TGFB3

involved_in

GO:0034616: response to laminar fluid shear stress

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:TGFB1

involved_in

GO:0034616: response to laminar fluid shear stress

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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