MOUSE:BMP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bmp2 (synonyms: Bmp-2)
Protein Name(s)	Bone morphogenetic protein 2 BMP-2 Bone morphogenetic protein 2A BMP-2A
External Links
UniProt	P21274
EMBL	L25602 AK133923 AK161862 AL831753 CH466519 BC100344
CCDS	CCDS16782.1
PIR	A34201 S45355
RefSeq	NP_031579.2
UniGene	Mm.103205
ProteinModelPortal	P21274
SMR	P21274
BioGrid	198363
PhosphoSite	P21274
PRIDE	P21274
Ensembl	ENSMUST00000028836
GeneID	12156
KEGG	mmu:12156
UCSC	uc008mnr.1
CTD	650
MGI	MGI:88177
eggNOG	NOG243555
GeneTree	ENSGT00760000118883
HOGENOM	HOG000249478
HOVERGEN	HBG004860
InParanoid	P21274
KO	K04662
OMA	DEHSWSQ
OrthoDB	EOG7WHH9D
TreeFam	TF351789
Reactome	REACT_198998 REACT_220505
NextBio	280499
PRO	PR:P21274
Proteomes	UP000000589
Bgee	P21274
CleanEx	MM_BMP2
Genevestigator	P21274
GO	GO:0009986 GO:0005615 GO:0070700 GO:0005125 GO:0019211 GO:0046982 GO:0004745 GO:0000187 GO:0003181 GO:0030509 GO:0003130 GO:0030282 GO:0035630 GO:0001658 GO:0060317 GO:0055007 GO:0055008 GO:0035051 GO:0045165 GO:0071773 GO:0071363 GO:0071407 GO:0002062 GO:0060128 GO:0035054 GO:0003203 GO:0001837 GO:0040007 GO:0007507 GO:0001701 GO:0006954 GO:0048839 GO:0048762 GO:0072138 GO:0060485 GO:0032348 GO:0051042 GO:0090090 GO:2000726 GO:0045786 GO:0008285 GO:2000065 GO:0010629 GO:0043569 GO:0000122 GO:0003308 GO:0007219 GO:0042475 GO:0009887 GO:0001649 GO:0055114 GO:0060389 GO:0060039 GO:0043065 GO:0048711 GO:0030501 GO:0061036 GO:0045597 GO:0030335 GO:0001938 GO:0010718 GO:0070374 GO:0045600 GO:0010628 GO:0050769 GO:0045666 GO:0042482 GO:0045778 GO:0045669 GO:0033690 GO:1900745 GO:0010862 GO:0010922 GO:0001934 GO:0045944 GO:1901522 GO:0030177 GO:0060804 GO:0031648 GO:0006029 GO:0042487 GO:0001666 GO:0060395 GO:0021537 GO:0021978 GO:0060129 GO:0007179
Gene3D	2.10.90.10
InterPro	IPR029034 IPR001839 IPR001111 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019 PF00688
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035630	bone mineralization involved in bone maturation	PMID:15039429^[1]	ECO:0000316			P		Figure 5 shows direct protein-protein interactions betwen PRDC and BMP2/4	Missing: with/from CACAO 9466
	GO:0006355	regulation of transcription, DNA-dependent	PMID:11788714^[2]	ECO:0000314			P		It is shown by figure 1 through a direct assay that BMP-2 is involved in the induction of Dlx-3 transcription.	complete CACAO 6359
	GO:2000383	regulation of ectoderm development	PMID:11788714^[2]	ECO:0000314			P		It is shown by figure 6 through a direct assay that BMP induces the Dlx-3 homeodomain, which regulates patterning in the embryonic ectoderm.	complete CACAO 6361
	GO:0042733	embryonic digit morphogenesis	PMID:8682290^[3]	ECO:0000314			P		As evidenced in figure 4 by the in situ hybridization, BMP-2 RNA transcripts are present in the terminal ends of the digits as they develop from the forelimb.	complete CACAO 6594
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:20675382^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:21145505^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21275	P	has_regulation_target:(RNAcentral:URS000075EEC2_10090) has_regulation_target:(RNAcentral:URS00002075FA_10090) has_regulation_target:(RNAcentral:URS0000574A2C_10090)	Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	PMID:21145505^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21275	P	occurs_in:(UBERON:0004145)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20890042^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q01705)	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:20675382^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	PMID:20675382^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:20675382^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	PMID:20890042^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development	PMID:15925496^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12151307^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218869 UniProtKB:P12643	F		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P		Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95689 MGI:MGI:95690 PANTHER:PTN000218210 RGD:2211 UniProtKB:O95393 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C		Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88177 PANTHER:PTN000218869 UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000726	negative regulation of cardiac muscle cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000065	negative regulation of cortisol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071773	cellular response to BMP stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19103752^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	PMID:7848824^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070724	BMP receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	C		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	PMID:7811286^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061036	positive regulation of cartilage development	PMID:10684250^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061036	positive regulation of cartilage development	PMID:3201241^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060804	positive regulation of Wnt signaling pathway by BMP signaling pathway	PMID:19213727^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060485	mesenchyme development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060395	SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060317	cardiac epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	PMID:9463347^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060128	corticotropin hormone secreting cell differentiation	PMID:9463347^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060039	pericardium development	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	results_in_development_of:(EMAPA:16131)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055008	cardiac muscle tissue morphogenesis	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	has_participant:(EMAPA:16339)\|has_participant:(EMAPA:16819)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051042	negative regulation of calcium-independent cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050769	positive regulation of neurogenesis	PMID:8616889^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49001	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:21795542^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048762	mesenchymal cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048711	positive regulation of astrocyte differentiation	PMID:15882580^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99414	P	regulates_o_occurs_in:(EMAPA:16910) regulates_o_results_in_acquisition_of_features_of:(CL:0000127)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048711	positive regulation of astrocyte differentiation	PMID:15882580^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16910) regulates_o_results_in_acquisition_of_features_of:(CL:0000127)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048711	positive regulation of astrocyte differentiation	PMID:10486560^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7811286^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	regulates_o_occurs_in:(EMAPA:16546) has_regulation_target:(MGI:MGI:102469)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:98872)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:97168)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:97169)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:1336883)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:97363)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:98330)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:98494)\|regulates_o_occurs_in(EMAPA:16546) has_regulation_target:(MGI:MGI:107821)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9769173^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9769173^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8769660^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97168)\|has_regulation_target:(MGI:MGI:97169)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20042692^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97362)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1468569^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95574)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10391928^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000034)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9187146^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8616889^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49001	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045778	positive regulation of ossification	PMID:21324897^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0007010)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045778	positive regulation of ossification	PMID:15820682^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045778	positive regulation of ossification	PMID:9213002^[30]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:16099986^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:15175325^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:9786991^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	PMID:15175325^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	PMID:15525533^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17919) regulates_o_results_in_acquisition_of_features_of:(CL:0000059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:12421925^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:9187146^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042487	regulation of odontogenesis of dentin-containing tooth	PMID:9244299^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180 MGI:MGI:99604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042482	positive regulation of odontogenesis	PMID:7848824^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(CL:0000345)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:15525533^[34]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:17919)	Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035630	bone mineralization involved in bone maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035054	embryonic heart tube anterior/posterior pattern specification	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035051	cardiocyte differentiation	PMID:15110716^[37]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035051	cardiocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032348	negative regulation of aldosterone biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	PMID:15322112^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	PMID:15322112^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:15975920^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2679262	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:25100727^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:20065295^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19852960^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:19208758^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:14623234^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	PMID:17472960^[45]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030501	positive regulation of bone mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:19213727^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101948 MGI:MGI:1922667	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:19213727^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:15657444^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	PMID:14627707^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021978	telencephalon regionalization	PMID:11719201^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:9187146^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	F		Seeded From UniProt	complete
enables	GO:0019211	phosphatase activator activity	PMID:9213002^[30]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010922	positive regulation of phosphatase activity	PMID:9213002^[30]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010894	negative regulation of steroid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:15322112^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:21624478^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:8898212^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857894	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[51]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15925496^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104903	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9187146^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006029	proteoglycan metabolic process	PMID:16935278^[52]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533 MGI:MGI:96533	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15110716^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2211	C		Seeded From UniProt	complete
enables	GO:0004745	retinol dehydrogenase activity	PMID:17473173^[53]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003203	endocardial cushion morphogenesis	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	has_participant:(EMAPA:16696)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003181	atrioventricular valve morphogenesis	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	has_participant:(EMAPA:16546)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003130	BMP signaling pathway involved in heart induction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002062	chondrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:17472960^[45]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	PMID:15110716^[37]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:16314491^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3583785	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:20042692^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857894	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:15925496^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104903	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19213727^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101948 MGI:MGI:1922667	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19208758^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87986 MGI:MGI:96440	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:16109715^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88182	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:15565649^[55]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99829	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19213727^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:19208758^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9585504^[56]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97485)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9187146^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12643	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004745	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:C8C060 ensembl:ENSP00000368104	C		Seeded From UniProt	complete
involved_in	GO:2000726	negative regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:2000065	negative regulation of cortisol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
part_of	GO:0070724	BMP receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	C		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0060485	mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0051042	negative regulation of calcium-independent cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
enables	GO:0039706	co-receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	F		Seeded From UniProt	complete
involved_in	GO:0035630	bone mineralization involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0035051	cardiocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0032348	negative regulation of aldosterone biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0021537	telencephalon development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
enables	GO:0019211	phosphatase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	F		Seeded From UniProt	complete
involved_in	GO:0010922	positive regulation of phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0010894	negative regulation of steroid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	C		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	C		Seeded From UniProt	complete
involved_in	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0003130	BMP signaling pathway involved in heart induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12643 ensembl:ENSP00000368104	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8898212^[50]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:8898212^[50]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0891	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sudo, S et al. (2004) Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J. Biol. Chem. 279 23134-41 PubMed GONUTS page
↑ ^2.0 ^2.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page
↑ Hogan, BL (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10 1580-94 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page
↑ ^5.0 ^5.1 Wang, J et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev. Cell 19 903-12 PubMed GONUTS page
↑ ^6.0 ^6.1 Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Ma, L et al. (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132 5601-11 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hartwig, S et al. (2005) Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech. Dev. 122 928-38 PubMed GONUTS page
↑ Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page
↑ ^12.0 ^12.1 Bègue-Kirn, C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int. J. Dev. Biol. 38 405-20 PubMed GONUTS page
↑ ^13.0 ^13.1 Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page
↑ Weston, AD et al. (2000) Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J. Cell Biol. 148 679-90 PubMed GONUTS page
↑ Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Friedman, MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J. Biol. Chem. 284 14117-25 PubMed GONUTS page
↑ ^17.0 ^17.1 Ericson, J et al. (1998) Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125 1005-15 PubMed GONUTS page
↑ ^18.0 ^18.1 Shah, NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 331-43 PubMed GONUTS page
↑ Lu, CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J. Neurosci. 31 10903-18 PubMed GONUTS page
↑ ^20.0 ^20.1 Bedford, L et al. (2005) Id4 is required for the correct timing of neural differentiation. Dev. Biol. 280 386-95 PubMed GONUTS page
↑ Nakashima, K et al. (1999) Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett. 457 43-6 PubMed GONUTS page
↑ ^22.0 ^22.1 Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page
↑ Thesleff, I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245 151-61 PubMed GONUTS page
↑ ^24.0 ^24.1 Anderson, L et al. (2010) Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 R833-42 PubMed GONUTS page
↑ Ohta, S et al. (1992) Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells. FEBS Lett. 314 356-60 PubMed GONUTS page
↑ Hollnagel, A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274 19838-45 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 Furuta, Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124 2203-12 PubMed GONUTS page
↑ Hu, R et al. (2011) A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 286 12328-39 PubMed GONUTS page
↑ Yamashita, M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121 101-13 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Balk, ML et al. (1997) Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim). Bone 21 7-15 PubMed GONUTS page
↑ Hong, JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 1074-8 PubMed GONUTS page
↑ ^32.0 ^32.1 Ichida, F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J. Biol. Chem. 279 34015-22 PubMed GONUTS page
↑ Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page
↑ ^34.0 ^34.1 Wang, XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev. Cell 7 719-30 PubMed GONUTS page
↑ Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page
↑ Neubüser, A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90 247-55 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Sugi, Y et al. (2004) Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice. Dev. Biol. 269 505-18 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Viñals, F & Ventura, F (2004) Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. J. Biol. Chem. 279 45766-72 PubMed GONUTS page
↑ Babitt, JL et al. (2005) Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J. Biol. Chem. 280 29820-7 PubMed GONUTS page
↑ Zhao, Y et al. (2014) C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J. Biol. Chem. 289 26441-50 PubMed GONUTS page
↑ Lee, DH et al. (2010) Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood 115 3136-45 PubMed GONUTS page
↑ Miwa, H et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett. 583 3643-8 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 Mukherjee, A & Rotwein, P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J. Cell. Sci. 122 716-26 PubMed GONUTS page
↑ Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page
↑ ^45.0 ^45.1 Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page
↑ Subramaniam, M et al. (2005) TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol. Cell. Biol. 25 1191-9 PubMed GONUTS page
↑ Roman-Roman, S et al. (2004) Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J. Biol. Chem. 279 5725-33 PubMed GONUTS page
↑ Monuki, ES et al. (2001) Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron 32 591-604 PubMed GONUTS page
↑ Heinonen, J et al. (2011) Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthr. Cartil. 19 1026-35 PubMed GONUTS page
↑ ^50.0 ^50.1 ^50.2 Zhang, H & Bradley, A (1996) Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122 2977-86 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
↑ Young, B et al. (2006) Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev. Biol. 299 272-82 PubMed GONUTS page
↑ Sandell, LL et al. (2007) RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 21 1113-24 PubMed GONUTS page
↑ Kugimiya, F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J. Biol. Chem. 280 35704-12 PubMed GONUTS page
↑ Young, DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J. Cell. Biochem. 94 720-30 PubMed GONUTS page
↑ McMahon, JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 12 1438-52 PubMed GONUTS page

[PMID:15039429-1] Sudo, S et al. (2004) Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J. Biol. Chem. 279 23134-41 PubMed GONUTS page

[PMID:11788714-2] 2.0 ^2.1 Park, GT & Morasso, MI (2002) Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes. Nucleic Acids Res. 30 515-22 PubMed GONUTS page

[PMID:8682290-3] Hogan, BL (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10 1580-94 PubMed GONUTS page

[PMID:20675382-4] 4.0 ^4.1 ^4.2 ^4.3 Su, JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J. Biol. Chem. 285 31325-36 PubMed GONUTS page

[PMID:21145505-5] 5.0 ^5.1 Wang, J et al. (2010) Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev. Cell 19 903-12 PubMed GONUTS page

[PMID:20890042-6] 6.0 ^6.1 Luna-Zurita, L et al. (2010) Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J. Clin. Invest. 120 3493-507 PubMed GONUTS page

[PMID:16314491-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Ma, L et al. (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132 5601-11 PubMed GONUTS page

[PMID:15925496-8] 8.0 ^8.1 ^8.2 Hartwig, S et al. (2005) Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech. Dev. 122 928-38 PubMed GONUTS page

[PMID:12151307-9] Rosendahl, A et al. (2002) Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am. J. Respir. Cell Mol. Biol. 27 160-9 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19103752-11] Zhao, M et al. (2009) Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29 1291-305 PubMed GONUTS page

[PMID:7848824-12] 12.0 ^12.1 Bègue-Kirn, C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int. J. Dev. Biol. 38 405-20 PubMed GONUTS page

[PMID:7811286-13] 13.0 ^13.1 Yamaji, N et al. (1994) A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem. Biophys. Res. Commun. 205 1944-51 PubMed GONUTS page

[PMID:10684250-14] Weston, AD et al. (2000) Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J. Cell Biol. 148 679-90 PubMed GONUTS page

[PMID:3201241-15] Wozney, JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242 1528-34 PubMed GONUTS page

[PMID:19213727-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Friedman, MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J. Biol. Chem. 284 14117-25 PubMed GONUTS page

[PMID:9463347-17] 17.0 ^17.1 Ericson, J et al. (1998) Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125 1005-15 PubMed GONUTS page

[PMID:8616889-18] 18.0 ^18.1 Shah, NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 331-43 PubMed GONUTS page

[PMID:21795542-19] Lu, CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J. Neurosci. 31 10903-18 PubMed GONUTS page

[PMID:15882580-20] 20.0 ^20.1 Bedford, L et al. (2005) Id4 is required for the correct timing of neural differentiation. Dev. Biol. 280 386-95 PubMed GONUTS page

[PMID:10486560-21] Nakashima, K et al. (1999) Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett. 457 43-6 PubMed GONUTS page

[PMID:9769173-22] 22.0 ^22.1 Dassule, HR & McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202 215-27 PubMed GONUTS page

[PMID:8769660-23] Thesleff, I et al. (1996) Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245 151-61 PubMed GONUTS page

[PMID:20042692-24] 24.0 ^24.1 Anderson, L et al. (2010) Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 R833-42 PubMed GONUTS page

[PMID:1468569-25] Ohta, S et al. (1992) Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells. FEBS Lett. 314 356-60 PubMed GONUTS page

[PMID:10391928-26] Hollnagel, A et al. (1999) Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J. Biol. Chem. 274 19838-45 PubMed GONUTS page

[PMID:9187146-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 Furuta, Y et al. (1997) Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development 124 2203-12 PubMed GONUTS page

[PMID:21324897-28] Hu, R et al. (2011) A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 286 12328-39 PubMed GONUTS page

[PMID:15820682-29] Yamashita, M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121 101-13 PubMed GONUTS page

[PMID:9213002-30] 30.0 ^30.1 ^30.2 Balk, ML et al. (1997) Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim). Bone 21 7-15 PubMed GONUTS page

[PMID:16099986-31] Hong, JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 1074-8 PubMed GONUTS page

[PMID:15175325-32] 32.0 ^32.1 Ichida, F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J. Biol. Chem. 279 34015-22 PubMed GONUTS page

[PMID:9786991-33] Li, W et al. (1998) Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J. Neurosci. 18 8853-62 PubMed GONUTS page

[PMID:15525533-34] 34.0 ^34.1 Wang, XP et al. (2004) Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev. Cell 7 719-30 PubMed GONUTS page

[PMID:12421925-35] Hager-Theodorides, AL et al. (2002) Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169 5496-504 PubMed GONUTS page

[PMID:9244299-36] Neubüser, A et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90 247-55 PubMed GONUTS page

[PMID:15110716-37] 37.0 ^37.1 ^37.2 Sugi, Y et al. (2004) Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice. Dev. Biol. 269 505-18 PubMed GONUTS page

[PMID:15322112-38] 38.0 ^38.1 ^38.2 Viñals, F & Ventura, F (2004) Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. J. Biol. Chem. 279 45766-72 PubMed GONUTS page

[PMID:15975920-39] Babitt, JL et al. (2005) Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J. Biol. Chem. 280 29820-7 PubMed GONUTS page

[PMID:25100727-40] Zhao, Y et al. (2014) C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. J. Biol. Chem. 289 26441-50 PubMed GONUTS page

[PMID:20065295-41] Lee, DH et al. (2010) Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis. Blood 115 3136-45 PubMed GONUTS page

[PMID:19852960-42] Miwa, H et al. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett. 583 3643-8 PubMed GONUTS page

[PMID:19208758-43] 43.0 ^43.1 ^43.2 Mukherjee, A & Rotwein, P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J. Cell. Sci. 122 716-26 PubMed GONUTS page

[PMID:14623234-44] Laurikkala, J et al. (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev. Biol. 264 91-105 PubMed GONUTS page

[PMID:17472960-45] 45.0 ^45.1 Xia, Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J. Biol. Chem. 282 18129-40 PubMed GONUTS page

[PMID:15657444-46] Subramaniam, M et al. (2005) TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol. Cell. Biol. 25 1191-9 PubMed GONUTS page

[PMID:14627707-47] Roman-Roman, S et al. (2004) Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J. Biol. Chem. 279 5725-33 PubMed GONUTS page

[PMID:11719201-48] Monuki, ES et al. (2001) Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron 32 591-604 PubMed GONUTS page

[PMID:21624478-49] Heinonen, J et al. (2011) Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthr. Cartil. 19 1026-35 PubMed GONUTS page

[PMID:8898212-50] 50.0 ^50.1 ^50.2 Zhang, H & Bradley, A (1996) Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development 122 2977-86 PubMed GONUTS page

[PMID:23012479-51] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:16935278-52] Young, B et al. (2006) Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev. Biol. 299 272-82 PubMed GONUTS page

[PMID:17473173-53] Sandell, LL et al. (2007) RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 21 1113-24 PubMed GONUTS page

[PMID:16109715-54] Kugimiya, F et al. (2005) Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J. Biol. Chem. 280 35704-12 PubMed GONUTS page

[PMID:15565649-55] Young, DW et al. (2005) SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J. Cell. Biochem. 94 720-30 PubMed GONUTS page

[PMID:9585504-56] McMahon, JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 12 1438-52 PubMed GONUTS page

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MOUSE:BMP2

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