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PMID:19852960

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Citation

Miwa, H, Miyake, A, Kouta, Y, Shimada, A, Yamashita, Y, Nakayama, Y, Yamauchi, H, Konishi, M and Itoh, N (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS Lett. 583:3643-8

Abstract

We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Brorin-like protein weakly but significantly inhibited the activity of BMP in mouse preosteoblastic cells and promoted neurogenesis in mouse neural precursor cells. Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues. The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development. Brorin-like potentially plays roles in neural development and functions.

Links

PubMed Online version:10.1016/j.febslet.2009.10.044

Keywords

3T3 Cells; Amino Acid Sequence; Animals; Astrocytes/cytology; Astrocytes/metabolism; Bone Morphogenetic Proteins/antagonists & inhibitors; Bone Morphogenetic Proteins/metabolism; COS Cells; Cell Differentiation/genetics; Cells, Cultured; Cercopithecus aethiops; Gene Expression Profiling; Gene Expression Regulation, Developmental; Glycoproteins/genetics; Glycoproteins/metabolism; Glycoproteins/pharmacology; Humans; In Situ Hybridization; Intercellular Signaling Peptides and Proteins/genetics; Intercellular Signaling Peptides and Proteins/metabolism; Intercellular Signaling Peptides and Proteins/pharmacology; Mice; Molecular Sequence Data; Nerve Tissue Proteins/genetics; Neurons/cytology; Neurons/metabolism; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction/drug effects; Zebrafish/embryology; Zebrafish/genetics; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:B0I1T8

involved_in

GO:0007399: nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DANRE:VWC2L

involved_in

GO:0007399: nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100102-2

P

Seeded From UniProt

complete

DANRE:VWC2L

involved_in

GO:0007399: nervous system development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-100102-1

P

Seeded From UniProt

complete

MOUSE:NOGG

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:88177
MGI:MGI:88182

P

Seeded From UniProt

complete

MOUSE:VWC2L

acts_upstream_of_or_within

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:88177
MGI:MGI:88182

P

Seeded From UniProt

complete

MOUSE:VWC2L

located_in

GO:0005615: extracellular space

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:VWC2L

acts_upstream_of_or_within

GO:0045666: positive regulation of neuron differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP2

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP6

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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