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PMID:1468569
| Citation |
Ohta, S, Hiraki, Y, Shigeno, C, Suzuki, F, Kasai, R, Ikeda, T, Kohno, H, Lee, K, Kikuchi, H and Konishi, J (1992) Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells. FEBS Lett. 314:356-60 |
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| Abstract |
Here we report that bone morphogenetic proteins 2 and 3 (BMP-2 and BMP-3) induced marked expression of c-fos mRNA in a biphasic manner, i.e. the late phase (48 to 60 h) as well as the immediate-early phase (0.5 h), in murine osteoblastic MC3T3-E1 cells in vitro. The BMP-induced late phase c-fos gene expression was temporally associated with the onset of marked expression of the genes for osteocalcin and alkaline phosphatase, differentiation markers of mature osteoblasts. In contrast, none of TGF-beta 1, 10% FBS, IGF-I and IGF-II, which induced only the immediate-early c-fos mRNA expression, stimulated the expression of osteocalcin and alkaline phosphatase genes. These data suggest that in osteoblasts BMP-2 and BMP-3 induce the late phase expression of c-fos, which may play a role in transcriptional activation of the genes involved in differentiation of osteoblasts. |
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| Keywords |
Animals; Bone Morphogenetic Protein 3; Bone Morphogenetic Proteins; Cattle; Cell Differentiation/genetics; Cell Differentiation/physiology; Cell Line; Gene Expression Regulation; Growth Substances/physiology; Mice; Osteoblasts/cytology; Osteoblasts/metabolism; Proteins/physiology; Proto-Oncogene Proteins c-fos/biosynthesis; Proto-Oncogene Proteins c-fos/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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