GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:9769173

From GONUTS
Jump to: navigation, search
Citation

Dassule, HR and McMahon, AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 202:215-27

Abstract

Epithelial-mesenchymal interactions govern the development of epidermal organs such as teeth. During the early stages of tooth development, a local ectodermal thickening which expresses several signaling molecules appears. It is believed that these in turn signal to the underlying mesenchyme triggering mesenchymal condensation and tooth development. For example, epithelially expressed Bmp4 induces Msx1 and Lef1 as well as itself in the underlying mesenchyme. In this paper we have investigated the role of four epithelial signaling molecules, Bmp2, Shh, Wnt10a, and Wnt10b, in the early inductive cascades that govern tooth development. We show that all four genes are specifically expressed in the epithelium between E11.0 and E12.0 when tooth morphogenesis is first apparent. Although Shh, Bmp2, and Wnt10b have similar, if not identical, expression patterns, each signal has a distinct molecular action on the jaw mesenchyme. Whereas Shh and Wnt10b can induce general Hedgehog and Wnt targets, Ptc and Gli for Shh and Lef1 for Wnt10b, only Bmp2 is able to induce tooth-specific expression of Msx1. Thus, there are distinct targets for all three pathways. Interestingly, both Bmp and Wnt signaling activate Lef1, making it a candidate for integrating the two distinct signaling pathways.

Links

PubMed Online version:10.1006/dbio.1998.8992

Keywords

3T3 Cells; Amphibian Proteins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins/genetics; Bone Morphogenetic Proteins/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Embryonic Induction/genetics; Embryonic Induction/physiology; Epithelium/embryology; Epithelium/metabolism; Gene Expression Regulation, Developmental; Hedgehog Proteins; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; In Situ Hybridization; Lymphoid Enhancer-Binding Factor 1; MSX1 Transcription Factor; Mesoderm/cytology; Mesoderm/metabolism; Mice; Odontogenesis/genetics; Odontogenesis/physiology; Proteins/genetics; Proteins/physiology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Signal Transduction; Tooth/embryology; Trans-Activators; Transcription Factors/genetics; Transcription Factors/physiology; Transforming Growth Factor beta; Wnt Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:BMP2

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(MGI:MGI:97168)

Seeded From UniProt

complete

MOUSE:LEF1

acts_upstream_of_or_within

GO:0030509: BMP signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:LEF1

involved_in

GO:0060070: canonical Wnt signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:WN10B

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(MGI:MGI:96770)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(MGI:MGI:108061)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(MGI:MGI:105373)|has_input:(MGI:MGI:95727)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:108061)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0000122: negative regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:105373)|has_regulation_target:(MGI:MGI:95727)

Seeded From UniProt

complete

MOUSE:SHH

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:GLI1

acts_upstream_of_or_within

GO:0007224: smoothened signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP2

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:BMP2

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97168)

Seeded From UniProt

complete

MOUSE:WNT1

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.