HUMAN:INHA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	INHA
Protein Name(s)	Inhibin alpha chain
External Links
UniProt	P05111
EMBL	M13981 X04445 X04446 BT006954 AK292340 CH471063 BC006391 M13144
CCDS	CCDS2444.1
PIR	A23556
RefSeq	NP_002182.1
UniGene	Hs.407506
ProteinModelPortal	P05111
SMR	P05111
BioGrid	109835
DIP	DIP-5826N
STRING	9606.ENSP00000243786
PhosphoSite	P05111
DMDM	124274
PaxDb	P05111
PRIDE	P05111
DNASU	3623
Ensembl	ENST00000243786
GeneID	3623
KEGG	hsa:3623
UCSC	uc002vmk.2
CTD	3623
GeneCards	GC02P220433
HGNC	HGNC:6065
HPA	CAB000047 HPA019141
MIM	147380
neXtProt	NX_P05111
PharmGKB	PA29876
eggNOG	NOG289440
GeneTree	ENSGT00390000005935
HOGENOM	HOG000013165
HOVERGEN	HBG052131
InParanoid	P05111
KO	K05500
OMA	GGYSFKY
OrthoDB	EOG7BS4BB
PhylomeDB	P05111
TreeFam	TF331531
Reactome	REACT_15398
GeneWiki	INHA
GenomeRNAi	3623
NextBio	14177
PRO	PR:P05111
Proteomes	UP000005640
Bgee	P05111
CleanEx	HS_INHA
Genevestigator	P05111
GO	GO:0005576 GO:0043512 GO:0034673 GO:0043025 GO:0001917 GO:0001750 GO:0005125 GO:0008083 GO:0005179 GO:0005102 GO:0007050 GO:0030154 GO:0007166 GO:0007267 GO:0030218 GO:0042541 GO:0008584 GO:0045578 GO:0045786 GO:0046882 GO:0045077 GO:0045650 GO:0042326 GO:0007399 GO:0001541 GO:0046881 GO:0051726 GO:0042127 GO:0009605 GO:0007165 GO:0001501
Gene3D	2.10.90.10
InterPro	IPR029034 IPR002405 IPR017175 IPR001839 IPR015615 IPR017948
PANTHER	PTHR11848
Pfam	PF00019
PIRSF	PIRSF037328
PRINTS	PR00669
SMART	SM00204
SUPFAM	SSF57501
PROSITE	PS00250 PS51362

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0034673	inhibin-betaglycan-ActRII complex	PMID:10746731^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:9032295^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043512	inhibin A complex	PMID:7890768^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:9032295^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9032295^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27037	F	Seeded From UniProt	complete
involved_in	GO:0046882	negative regulation of follicle-stimulating hormone secretion	PMID:3267209^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042541	hemoglobin biosynthetic process	PMID:1310063^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:1310063^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	PMID:9166111^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338027 MGI:MGI:88180 MGI:MGI:88182 MGI:MGI:95689 MGI:MGI:97359 PANTHER:PTN000218063 UniProtKB:O95390 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22004 UniProtKB:P43026 UniProtKB:P61812 UniProtKB:Q6KF10 UniProtKB:Q99988	P	Seeded From UniProt	complete
involved_in	GO:0048468	cell development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103302 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98726 PANTHER:PTN000218063	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107335 MGI:MGI:1338820 MGI:MGI:88182 MGI:MGI:95684 MGI:MGI:98727 PANTHER:PTN000218063 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P08476 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P22003 UniProtKB:P22004 UniProtKB:Q6KF10 UniProtKB:Q7Z4P5 UniProtKB:Q96S42 UniProtKB:Q9UK05	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000490 MGI:MGI:103302 MGI:MGI:1338027 MGI:MGI:88177 MGI:MGI:88180 MGI:MGI:95691 MGI:MGI:98725 MGI:MGI:98726 PANTHER:PTN000218063 RGD:1305979 RGD:2211 RGD:2212 RGD:2213 RGD:2214 RGD:2912 RGD:2913 RGD:3115 RGD:3851 RGD:62074 RGD:620743 RGD:621512 RGD:69051 RGD:70491 UniProtKB:O14793 UniProtKB:O42220 UniProtKB:O95393 UniProtKB:P01137 UniProtKB:P12643 UniProtKB:P12644 UniProtKB:P18075 UniProtKB:P30371 UniProtKB:P61812 UniProtKB:Q96S42 UniProtKB:Q99988 WB:WBGene00000903	C	Seeded From UniProt	complete
enables	GO:0005160	transforming growth factor beta receptor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98725 PANTHER:PTN000218063 UniProtKB:P61812	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000218063 UniProtKB:P08476 UniProtKB:P12644	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	F	Seeded From UniProt	complete
involved_in	GO:0046882	negative regulation of follicle-stimulating hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	P	Seeded From UniProt	complete
part_of	GO:0043513	inhibin B complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
part_of	GO:0043512	inhibin A complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
enables	GO:0034711	inhibin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	F	Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	C	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17490 ensembl:ENSRNOP00000027227	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001839 InterPro:IPR017948	F	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:3267209^[4] PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:3035540^[9] PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:3267209^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:3267209^[4] PMID:3035540^[9] PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:3035540^[9] PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:10865214^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046881	positive regulation of follicle-stimulating hormone secretion	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045650	negative regulation of macrophage differentiation	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045578	negative regulation of B cell differentiation	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045077	negative regulation of interferon-gamma biosynthetic process	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:12324653^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12456957^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lewis, KA et al. (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404 411-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lebrun, JJ & Vale, WW (1997) Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol. Cell. Biol. 17 1682-91 PubMed GONUTS page
↑ Xu, J et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J. Biol. Chem. 270 6308-13 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Murata, M et al. (1988) Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc. Natl. Acad. Sci. U.S.A. 85 2434-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Shao, L et al. (1992) Effect of activin A on globin gene expression in purified human erythroid progenitors. Blood 79 773-81 PubMed GONUTS page
↑ Evans, LW et al. (1997) Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB. J. Endocrinol. 153 221-30 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Shav-Tal, Y & Zipori, D (2002) The role of activin a in regulation of hemopoiesis. Stem Cells 20 493-500 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ramasharma, K & Li, CH (1987) Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes. Proc. Natl. Acad. Sci. U.S.A. 84 3595-8 PubMed GONUTS page
↑ Sakai, R et al. (2000) Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats. Bone 27 91-6 PubMed GONUTS page
↑ Welt, C et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp. Biol. Med. (Maywood) 227 724-52 PubMed GONUTS page

[PMID:10746731-1] Lewis, KA et al. (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404 411-4 PubMed GONUTS page

[PMID:9032295-2] 2.0 ^2.1 ^2.2 Lebrun, JJ & Vale, WW (1997) Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol. Cell. Biol. 17 1682-91 PubMed GONUTS page

[PMID:7890768-3] Xu, J et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J. Biol. Chem. 270 6308-13 PubMed GONUTS page

[PMID:3267209-4] 4.0 ^4.1 ^4.2 ^4.3 Murata, M et al. (1988) Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Proc. Natl. Acad. Sci. U.S.A. 85 2434-8 PubMed GONUTS page

[PMID:1310063-5] 5.0 ^5.1 Shao, L et al. (1992) Effect of activin A on globin gene expression in purified human erythroid progenitors. Blood 79 773-81 PubMed GONUTS page

[PMID:9166111-6] Evans, LW et al. (1997) Development, validation and application of a two-site enzyme-linked immunosorbent assay for activin-AB. J. Endocrinol. 153 221-30 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12456957-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 Shav-Tal, Y & Zipori, D (2002) The role of activin a in regulation of hemopoiesis. Stem Cells 20 493-500 PubMed GONUTS page

[PMID:3035540-9] 9.0 ^9.1 ^9.2 Ramasharma, K & Li, CH (1987) Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes. Proc. Natl. Acad. Sci. U.S.A. 84 3595-8 PubMed GONUTS page

[PMID:10865214-10] Sakai, R et al. (2000) Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats. Bone 27 91-6 PubMed GONUTS page

[PMID:12324653-11] Welt, C et al. (2002) Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium. Exp. Biol. Med. (Maywood) 227 724-52 PubMed GONUTS page

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HUMAN:INHA

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Notes

References

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