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MOUSE:TGFB1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tgfb1
Protein Name(s) Transforming growth factor beta-1

TGF-beta-1 Latency-associated peptide LAP

External Links
UniProt P04202
EMBL M13177
L42462
L42456
L42457
L42458
L42459
L42460
L42461
AJ009862
BC013738
CCDS CCDS20993.1
PIR A01396
RefSeq NP_035707.1
UniGene Mm.248380
ProteinModelPortal P04202
SMR P04202
BioGrid 204157
DIP DIP-48640N
STRING 10090.ENSMUSP00000002678
PhosphoSite P04202
PaxDb P04202
PRIDE P04202
Ensembl ENSMUST00000002678
GeneID 21803
KEGG mmu:21803
UCSC uc009ftq.1
CTD 7040
MGI MGI:98725
eggNOG NOG279949
HOGENOM HOG000290198
HOVERGEN HBG074115
InParanoid P04202
KO K13375
OMA SHSIYMF
OrthoDB EOG70GMFT
PhylomeDB P04202
TreeFam TF318514
Reactome REACT_196549
REACT_196606
REACT_196644
REACT_198998
REACT_203510
REACT_209370
REACT_215733
REACT_216792
REACT_217958
REACT_224217
REACT_224787
REACT_224802
REACT_252217
REACT_27166
NextBio 301176
PMAP-CutDB P04202
PRO PR:P04202
Proteomes UP000000589
Bgee P04202
CleanEx MM_TGFB1
ExpressionAtlas P04202
Genevestigator P04202
GO GO:0030424
GO:0072562
GO:0009986
GO:0005737
GO:0031012
GO:0005615
GO:0005902
GO:0043025
GO:0005634
GO:0005578
GO:0030141
GO:0003823
GO:0005160
GO:0005114
GO:0002460
GO:0007568
GO:0006754
GO:0060751
GO:0001775
GO:0007050
GO:0016049
GO:0008283
GO:0045216
GO:0006874
GO:0071549
GO:0071363
GO:0071407
GO:0071560
GO:0002062
GO:0007182
GO:0006952
GO:0009817
GO:0048565
GO:0007492
GO:0007173
GO:0001837
GO:0019049
GO:0085029
GO:0097191
GO:0060325
GO:0007565
GO:0060364
GO:0008354
GO:0002244
GO:0030214
GO:0006954
GO:0048839
GO:0070306
GO:0031663
GO:0048535
GO:0060744
GO:0030879
GO:0000165
GO:0007093
GO:0032943
GO:0042552
GO:0043011
GO:0043537
GO:0045786
GO:0030308
GO:0008285
GO:0022408
GO:0008156
GO:0050680
GO:0045599
GO:1900126
GO:0010936
GO:0045930
GO:0045662
GO:0007406
GO:0030279
GO:0050765
GO:0001933
GO:0051280
GO:0048642
GO:0050868
GO:0042130
GO:0000122
GO:0045892
GO:0009887
GO:0031100
GO:0043932
GO:0060389
GO:0006796
GO:0043065
GO:0043536
GO:0030501
GO:0090190
GO:0071158
GO:0030335
GO:0008284
GO:0032270
GO:0050921
GO:0032967
GO:0050679
GO:0010718
GO:0031536
GO:0010763
GO:0010628
GO:0035066
GO:0031065
GO:0032740
GO:0048298
GO:0043406
GO:1901666
GO:0051092
GO:0042482
GO:0010862
GO:0033138
GO:0010800
GO:0043552
GO:0031334
GO:0035307
GO:0051897
GO:1900182
GO:0001934
GO:0050714
GO:0060391
GO:0051152
GO:0032930
GO:0045944
GO:2000679
GO:0045893
GO:0006611
GO:0000060
GO:0043491
GO:0006468
GO:0032801
GO:2000249
GO:0051098
GO:0060762
GO:0061035
GO:0042127
GO:0051101
GO:2000628
GO:0042306
GO:0002028
GO:0016202
GO:0017015
GO:0045066
GO:0070723
GO:0042493
GO:0032355
GO:0009749
GO:0001666
GO:0034616
GO:0032570
GO:0009314
GO:0033280
GO:0007435
GO:0007519
GO:0001501
GO:0007183
GO:0007184
GO:0042110
GO:0030217
GO:0043029
GO:0002513
GO:0007179
GO:0001657
GO:0042060
Gene3D 2.10.90.10
InterPro IPR029034
IPR001839
IPR001111
IPR016319
IPR015615
IPR003939
IPR017948
PANTHER PTHR11848
Pfam PF00019
PF00688
PIRSF PIRSF001787
PRINTS PR01423
PR01424
SMART SM00204
SUPFAM SSF57501
PROSITE PS00250
PS51362

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010629

negative regulation of gene expression

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002137)
  • regulates_expression_of:(ENSEMBL:ENSMUSG00000039153)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002137)
  • regulates_expression_of:(ENSEMBL:ENSMUSG00000022483)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002137)
  • regulates_expression_of:(ENSEMBL:ENSMUSG00000024563)

Seeded From UniProt

complete

involved_in

GO:0070168

negative regulation of biomineral tissue development

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002137)
  • regulates_expression_of:(ENSEMBL:ENSMUSG00000000567)

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

PMID:26634652[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0002137)

Seeded From UniProt

complete

involved_in

GO:0014008

positive regulation of microglia differentiation

PMID:29909984[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:1905005

regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

PMID:19161227[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1990402

embryonic liver development

PMID:7600998[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:7600998[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

PMID:7600998[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

PMID:7600998[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001570

vasculogenesis

PMID:7600998[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055010

ventricular cardiac muscle tissue morphogenesis

PMID:8009224[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003179

heart valve morphogenesis

PMID:8009224[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:1905313

transforming growth factor beta receptor signaling pathway involved in heart development

PMID:8009224[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031293

membrane protein intracellular domain proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21984612[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043539

protein serine/threonine kinase activator activity

PMID:25065622[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1903911

positive regulation of receptor clustering

PMID:25065622[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045591

positive regulation of regulatory T cell differentiation

PMID:25065622[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000902)

Seeded From UniProt

complete

involved_in

GO:0060390

regulation of SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032667

regulation of interleukin-23 production

PMID:18368049[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032700

negative regulation of interleukin-17 production

PMID:18368049[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043932

ossification involved in bone remodeling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

enables

GO:0003823

antigen binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

involved_in

GO:0007435

salivary gland morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0010936

negative regulation of macrophage cytokine production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0048298

positive regulation of isotype switching to IgA isotypes

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

enables

GO:0034713

type I transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

involved_in

GO:0014003

oligodendrocyte development

PMID:22384214[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0085029

extracellular matrix assembly

PMID:19734317[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

PMID:12773577[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

PMID:19734317[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032740

positive regulation of interleukin-17 production

PMID:19501566[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

PMID:12773577[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19734317[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002460

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

PMID:19501566[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:1901666

positive regulation of NAD+ ADP-ribosyltransferase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:1900126

negative regulation of hyaluronan biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0070723

response to cholesterol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0060325

face morphogenesis

PMID:18498113[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0050921

positive regulation of chemotaxis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0050714

positive regulation of protein secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0048642

negative regulation of skeletal muscle tissue development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045930

negative regulation of mitotic cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045599

negative regulation of fat cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0045216

cell-cell junction organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0043537

negative regulation of blood vessel endothelial cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0043491

protein kinase B signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0035307

positive regulation of protein dephosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032801

receptor catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0032270

positive regulation of cellular protein metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0030214

hyaluronan catabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

GO:0014003

oligodendrocyte development

PMID:22384214[9]

ECO:0000315

P

Figure 2a & Figure 2b. Loss of Pescadillo gene results in loss of dorsal oligodendrocytes.

complete
CACAO 3903

involved_in

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0019049

evasion or tolerance of host defenses by virus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0010763

positive regulation of fibroblast migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007183

SMAD protein complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007173

epidermal growth factor receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0006796

phosphate-containing compound metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0006754

ATP biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0006611

protein export from nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

colocalizes_with

GO:0005902

microvillus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

PMID:14656760[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338027
MGI:MGI:88180
MGI:MGI:88182
MGI:MGI:95689
MGI:MGI:97359
PANTHER:PTN000218063
UniProtKB:O95390
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22004
UniProtKB:P43026
UniProtKB:P61812
UniProtKB:Q6KF10
UniProtKB:Q99988

P

Seeded From UniProt

complete

involved_in

GO:0048468

cell development

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103302
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98726
PANTHER:PTN000218063

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218722

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107335
MGI:MGI:1338820
MGI:MGI:88182
MGI:MGI:95684
MGI:MGI:98727
PANTHER:PTN000218063
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P08476
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P22003
UniProtKB:P22004
UniProtKB:Q6KF10
UniProtKB:Q7Z4P5
UniProtKB:Q96S42
UniProtKB:Q9UK05

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218722
UniProtKB:P01137
UniProtKB:P10600
UniProtKB:P61812

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000490
MGI:MGI:103302
MGI:MGI:1338027
MGI:MGI:88177
MGI:MGI:88180
MGI:MGI:95691
MGI:MGI:98725
MGI:MGI:98726
PANTHER:PTN000218063
RGD:1305979
RGD:2211
RGD:2212
RGD:2213
RGD:2214
RGD:2912
RGD:2913
RGD:3115
RGD:3851
RGD:62074
RGD:620743
RGD:621512
RGD:69051
RGD:70491
UniProtKB:O14793
UniProtKB:O42220
UniProtKB:O95393
UniProtKB:P01137
UniProtKB:P12643
UniProtKB:P12644
UniProtKB:P18075
UniProtKB:P30371
UniProtKB:P61812
UniProtKB:Q96S42
UniProtKB:Q99988
WB:WBGene00000903

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98725
PANTHER:PTN000218063
UniProtKB:P61812

F

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218063
UniProtKB:P08476
UniProtKB:P12644

F

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218722
UniProtKB:P01137
UniProtKB:P10600
UniProtKB:P61812

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000727

positive regulation of cardiac muscle cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000249

regulation of actin cytoskeleton reorganization

PMID:21911934[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1330281

P

regulates_o_occurs_in:(CL:0000653)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903799

negative regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903077

negative regulation of protein localization to plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901666

positive regulation of NAD+ ADP-ribosyltransferase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900182

positive regulation of protein localization to nucleus

PMID:21911934[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1330281

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900126

negative regulation of hyaluronan biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0085029

extracellular matrix assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071677

positive regulation of mononuclear cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071560

cellular response to transforming growth factor beta stimulus

PMID:23861879[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071549

cellular response to dexamethasone stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071363

cellular response to growth factor stimulus

PMID:7848824[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071158

positive regulation of cell cycle arrest

PMID:19056892[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070723

response to cholesterol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070306

lens fiber cell differentiation

PMID:17215516[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_acquisition_of_features_of:(CL:0000306)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070168

negative regulation of biomineral tissue development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061448

connective tissue development

PMID:25715398[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061035

regulation of cartilage development

PMID:20501701[22]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060965

negative regulation of gene silencing by miRNA

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060762

regulation of branching involved in mammary gland duct morphogenesis

PMID:17898001[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98958

P

has_participant:(EMAPA:35538)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060751

branch elongation involved in mammary gland duct branching

PMID:18614704[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060744

mammary gland branching involved in thelarche

PMID:18614704[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060390

regulation of SMAD protein signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060389

pathway-restricted SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051280

negative regulation of release of sequestered calcium ion into cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051152

positive regulation of smooth muscle cell differentiation

PMID:8616889[25]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P17246

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051101

regulation of DNA binding

PMID:15282343[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051098

regulation of binding

PMID:15282343[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050921

positive regulation of chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050868

negative regulation of T cell activation

PMID:12646629[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

regulates_o_occurs_in:(CL:0000893)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050777

negative regulation of immune response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050765

negative regulation of phagocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050714

positive regulation of protein secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048642

negative regulation of skeletal muscle tissue development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048535

lymph node development

PMID:1436033[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048298

positive regulation of isotype switching to IgA isotypes

PMID:14988498[29]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048146

positive regulation of fibroblast proliferation

PMID:23871832[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046716

muscle cell cellular homeostasis

PMID:25715398[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96817

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17568773[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108051
MGI:MGI:1347465
MGI:MGI:894293

P

has_regulation_target:(MGI:MGI:1351322)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18997793[32]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1891436)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17951031[33]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15990875[34]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:1100518)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045930

negative regulation of mitotic cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045918

negative regulation of cytolysis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15282343[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15100250[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045786

negative regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045599

negative regulation of fat cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045589

regulation of regulatory T cell differentiation

PMID:21245484[36]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88327

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045216

cell-cell junction organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045066

regulatory T cell differentiation

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576270
MGI:MGI:3719583

P

  • occurs_in:(EMAPA:18768)
  • results_in_acquisition_of_features_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045066

regulatory T cell differentiation

PMID:15100250[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043537

negative regulation of blood vessel endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043491

protein kinase B signaling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043117

positive regulation of vascular permeability

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043029

T cell homeostasis

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

occurs_in:(EMAPA:35523)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043011

myeloid dendritic cell differentiation

PMID:17938236[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

  • occurs_in:(EMAPA:17525)
  • results_in_acquisition_of_features_of:(CL:0000453)

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042552

myelination

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042482

positive regulation of odontogenesis

PMID:7848824[18]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_has_participant:(CL:0000345)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042306

regulation of protein import into nucleus

PMID:11799106[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042130

negative regulation of T cell proliferation

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

regulates_o_occurs_in:(EMAPA:35523)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:11799106[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042110

T cell activation

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

has_participant:(EMAPA:35523)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042110

T cell activation

PMID:18997793[32]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042060

wound healing

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035307

positive regulation of protein dephosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035066

positive regulation of histone acetylation

PMID:15990875[34]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

enables

GO:0034713

type I transforming growth factor beta receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032943

mononuclear cell proliferation

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

occurs_in:(EMAPA:16728)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032801

receptor catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032740

positive regulation of interleukin-17 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032570

response to progesterone

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032355

response to estradiol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032270

positive regulation of cellular protein metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031536

positive regulation of exit from mitosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031293

membrane protein intracellular domain proteolysis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031100

animal organ regeneration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031065

positive regulation of histone deacetylation

PMID:15990875[34]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031065

positive regulation of histone deacetylation

PMID:15657445[40]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:9008713[41]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:2209468[42]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16728)|part_of:(EMAPA:16728)|part_of:(EMAPA:16728)

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:18835815[43]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:12208849[44]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0035411

catenin import into nucleus

PMID:16690606[45]

ECO:0000314

P

Figure 3

complete
CACAO 11759

acts_upstream_of_or_within

GO:0030879

mammary gland development

PMID:1821856[46]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030316

osteoclast differentiation

PMID:21841309[47]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2179720

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030316

osteoclast differentiation

PMID:21841309[47]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030308

negative regulation of cell growth

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030279

negative regulation of ossification

PMID:15820682[48]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030217

T cell differentiation

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

occurs_in:(EMAPA:35523)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030214

hyaluronan catabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019049

evasion or tolerance of host defenses by virus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016477

cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016202

regulation of striated muscle tissue development

PMID:11711431[49]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010936

negative regulation of macrophage cytokine production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010763

positive regulation of fibroblast migration

PMID:23871832[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010763

positive regulation of fibroblast migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010718

positive regulation of epithelial to mesenchymal transition

PMID:18794329[50]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

PMID:29529050[51]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010629

negative regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:17293613[52]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:97798)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:23871832[30]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010033

response to organic substance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009817

defense response to fungus, incompatible interaction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008354

germ cell migration

PMID:15993878[53]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_movement_of:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:15604101[54]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:12208849[44]

ECO:0000314

direct assay evidence used in manual assertion

P

acts_on_population_of:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007492

endoderm development

PMID:9921650[55]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007406

negative regulation of neuroblast proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007219

Notch signaling pathway

PMID:25446530[56]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007183

SMAD protein complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:8429908[57]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:23868260[58]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:12208849[44]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007173

epidermal growth factor receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007050

cell cycle arrest

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006954

inflammatory response

PMID:8421714[59]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857671

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006954

inflammatory response

PMID:1436033[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006954

inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006874

cellular calcium ion homeostasis

PMID:12646629[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857258

P

occurs_in:(CL:0000893)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006796

phosphate-containing compound metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006754

ATP biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006611

protein export from nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:17898001[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98958

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:12208849[44]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

colocalizes_with

GO:0005902

microvillus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18753609[60]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000235)|part_of:(CL:0000115)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

C

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:17878231[61]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q64729

F

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:17878231[61]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q62312

F

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

enables

GO:0003823

antigen binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003180

aortic valve morphogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002513

tolerance induction to self antigen

PMID:17481928[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3719583

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002062

chondrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002028

regulation of sodium ion transport

PMID:16941024[62]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001837

epithelial to mesenchymal transition

PMID:29529050[51]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001775

cell activation

PMID:21956870[63]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001763

morphogenesis of a branching structure

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69051

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000165

MAPK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01137

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18212064[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:106203
MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15990875[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99829

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15990875[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1333784
MGI:MGI:3036234
MGI:MGI:99829

P

has_regulation_target:(MGI:MGI:88156)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15657445[40]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:87951)

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010763

positive regulation of fibroblast migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

C

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007435

salivary gland morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007183

SMAD protein complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007182

common-partner SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007173

epidermal growth factor receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007093

mitotic cell cycle checkpoint

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0006796

phosphate-containing compound metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0006754

ATP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0006611

protein export from nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

C

Seeded From UniProt

complete

enables

GO:0005114

type II transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

enables

GO:0003823

antigen binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0002244

hematopoietic progenitor cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0002062

chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:2000727

positive regulation of cardiac muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:2000679

positive regulation of transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1903799

negative regulation of production of miRNAs involved in gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1903077

negative regulation of protein localization to plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1901666

positive regulation of NAD+ ADP-ribosyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1900182

positive regulation of protein localization to nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1900126

negative regulation of hyaluronan biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0085029

extracellular matrix assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0070723

response to cholesterol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0070168

negative regulation of biomineral tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0060391

positive regulation of SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0060390

regulation of SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0060389

pathway-restricted SMAD protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0050921

positive regulation of chemotaxis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0050714

positive regulation of protein secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0048642

negative regulation of skeletal muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0048298

positive regulation of isotype switching to IgA isotypes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045930

negative regulation of mitotic cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045918

negative regulation of cytolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045786

negative regulation of cell cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045599

negative regulation of fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0045216

cell-cell junction organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043932

ossification involved in bone remodeling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043537

negative regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043491

protein kinase B signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0043117

positive regulation of vascular permeability

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

involved_in

GO:0042307

positive regulation of protein import into nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0035307

positive regulation of protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

enables

GO:0034714

type III transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

enables

GO:0034713

type I transforming growth factor beta receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

involved_in

GO:0033138

positive regulation of peptidyl-serine phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032801

receptor catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032740

positive regulation of interleukin-17 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0032270

positive regulation of cellular protein metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0031334

positive regulation of protein complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0031293

membrane protein intracellular domain proteolysis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0030214

hyaluronan catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

F

Seeded From UniProt

complete

involved_in

GO:0019049

evasion or tolerance of host defenses by virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:0010936

negative regulation of macrophage cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01137
ensembl:ENSP00000221930

P

Seeded From UniProt

complete

involved_in

GO:1990314

cellular response to insulin-like growth factor stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:1902074

response to salt

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0071677

positive regulation of mononuclear cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0071549

cellular response to dexamethasone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0071479

cellular response to ionizing radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0071260

cellular response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

involved_in

GO:0060364

frontal suture morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0051280

negative regulation of release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0051152

positive regulation of smooth muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0050777

negative regulation of immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0050765

negative regulation of phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0048839

inner ear development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0048565

digestive tract development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

F

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0035902

response to immobilization stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0034616

response to laminar fluid shear stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0033280

response to vitamin D

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0032967

positive regulation of collagen biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0031536

positive regulation of exit from mitosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0031100

animal organ regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

involved_in

GO:0009817

defense response to fungus, incompatible interaction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0007406

negative regulation of neuroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

C

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0001763

morphogenesis of a branching structure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P17246
ensembl:ENSRNOP00000028051

P

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003939

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016319

C

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001839
InterPro:IPR017948

F

Seeded From UniProt

complete

involved_in

GO:0072540

T-helper 17 cell lineage commitment

PMID:18368049[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002362

CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment

PMID:18368049[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032829

regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

PMID:18368049[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:8421714[59]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:8421714[59]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:8421714[59]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

acts_on_population_of:(CL:0000738)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007519

skeletal muscle tissue development

PMID:1436033[28]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006952

defense response

PMID:8421714[59]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005160

transforming growth factor beta receptor binding

PMID:1436033[28]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:8421714[59]
PMID:1436033[28]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

involved_in

GO:0051781

positive regulation of cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Huk, DJ et al. (2016) Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Arterioscler. Thromb. Vasc. Biol. 36 328-38 PubMed GONUTS page
  2. ↑ Qin, Y et al. (2018) A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell 174 156-171.e16 PubMed GONUTS page
  3. ↑ Azhar, M et al. (2009) Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev. Dyn. 238 431-42 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Dickson, MC et al. (1995) Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121 1845-54 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Letterio, JJ et al. (1994) Maternal rescue of transforming growth factor-beta 1 null mice. Science 264 1936-8 PubMed GONUTS page
  6. ↑ Mihira, H et al. (2012) TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A. J. Biochem. 151 145-56 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Wu, C et al. (2014) Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 270-82 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Zhou, L et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453 236-40 PubMed GONUTS page
  9. ↑ 9.0 9.1 Simmons, T & Appel, B (2012) Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS ONE 7 e32317 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Salazar, KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L1002-11 PubMed GONUTS page
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  25. ↑ Shah, NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85 331-43 PubMed GONUTS page
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  29. ↑ Castigli, E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 101 3903-8 PubMed GONUTS page
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  33. ↑ Kettunen, P et al. () Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech. Dev. 124 868-83 PubMed GONUTS page
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  35. ↑ 35.0 35.1 Fantini, MC et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172 5149-53 PubMed GONUTS page
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  38. ↑ Kaplan, DH et al. (2007) Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J. Exp. Med. 204 2545-52 PubMed GONUTS page
  39. ↑ 39.0 39.1 Chang, NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J. Biol. Chem. 277 10323-31 PubMed GONUTS page
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  41. ↑ Nakajima, Y et al. (1997) Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J. Cell Biol. 136 193-204 PubMed GONUTS page
  42. ↑ Heine, UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109 29-36 PubMed GONUTS page
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  45. ↑ Li, TF et al. (2006) Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J. Biol. Chem. 281 21296-304 PubMed GONUTS page
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  47. ↑ 47.0 47.1 Barrow, AD et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121 3505-16 PubMed GONUTS page
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  49. ↑ Liu, D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 15 2950-66 PubMed GONUTS page
  50. ↑ Hirano, M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J. Cell Biol. 182 1217-30 PubMed GONUTS page
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  53. ↑ Chuva de Sousa Lopes, SM et al. (2005) Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5. Dev. Biol. 284 194-203 PubMed GONUTS page
  54. ↑ Kettunen, P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132 323-34 PubMed GONUTS page
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