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PMID:18498113

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Citation

Anthwal, N, Chai, Y and Tucker, AS (2008) The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev. Dyn. 237:1604-13

Abstract

The evolution of the novel mammalian jaw articulation has resulted in an increased complexity of the dentary bone, reflecting the multiple roles it now fulfils as the primary bone of the mandible. Signalling through the Tgf-beta type II receptor is important in the development and patterning of the proximal dentary processes, especially the angular process, and secondary cartilages. We show that expression of Tgf-beta2 is associated with the developing angular process, and that the connective tissue marker Scleraxis is co-expressed with Tgf-beta2. Scleraxis expression is lost around the angular process of Tgfbr2 conditional knockouts and Tgf-beta signalling can induce Scleraxis expression in explant culture. Induction of secondary cartilages in explant culture can be prevented by inhibition of Tgf-beta signalling. This study suggests that the proper development of the processes and their secondary cartilages relies on both Tgf-beta signalling and mechanical forces working in concert.

Links

PubMed Online version:10.1002/dvdy.21567

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors/metabolism; Body Patterning; Cartilage/metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; In Situ Hybridization; Mandible/embryology; Mandible/metabolism; Mice; Organ Culture Techniques; Phenotype; Protein-Serine-Threonine Kinases/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Signal Transduction; Time Factors; Transforming Growth Factor beta/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:TGFB3

involved_in

GO:0060325: face morphogenesis

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TGFB2

involved_in

GO:0010628: positive regulation of gene expression

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TGFB2

involved_in

GO:0060325: face morphogenesis

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TGFR2

involved_in

GO:0051216: cartilage development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SCX

involved_in

GO:0060325: face morphogenesis

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SCX

involved_in

GO:0071560: cellular response to transforming growth factor beta stimulus

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:TGFB1

involved_in

GO:0060325: face morphogenesis

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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