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PMID:17481928
| Citation |
Li, MO, Wan, YY and Flavell, RA (2007) T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26:579-91 |
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| Abstract |
TGF-beta1 is a regulatory cytokine with a pleiotropic role in immune responses. TGF-beta1 is widely expressed in leukocytes and stromal cells. However, the functions of TGF-beta1 expressed by specific lineages of cells remain unknown in vivo. Here, we show that mice with a T cell-specific deletion of the Tgfb1 gene developed lethal immunopathology in multiple organs, and this development was associated with enhanced T cell proliferation, activation, and CD4+ T cell differentiation into T helper 1 (Th1) and Th2 cells. TGF-beta1 produced by Foxp3-expressing regulatory T cells was required to inhibit Th1-cell differentiation and inflammatory-bowel disease in a transfer model. In addition, T cell-produced TGF-beta1 promoted Th17-cell differentiation and was indispensable for the induction of experimental autoimmune encephalomyelitis. These findings reveal essential roles for T cell-produced TGF-beta1 in controlling differentiation of T helper cells and controlling inflammatory diseases. |
| Links |
PubMed Online version:10.1016/j.immuni.2007.03.014 |
| Keywords |
Animals; Cell Differentiation/immunology; Cells, Cultured; Colitis/genetics; Colitis/immunology; Colitis/metabolism; Colitis/pathology; Encephalomyelitis, Autoimmune, Experimental/genetics; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/metabolism; Encephalomyelitis, Autoimmune, Experimental/pathology; Forkhead Transcription Factors/metabolism; Gene Deletion; Gene Expression Regulation; Homeostasis; Immune Tolerance/immunology; Lymphocyte Activation/immunology; Mice; Mice, Knockout; T-Lymphocytes/cytology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Transforming Growth Factor beta1/biosynthesis; Transforming Growth Factor beta1/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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