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PMID:1436033
| Citation |
Shull, MM, Ormsby, I, Kier, AB, Pawlowski, S, Diebold, RJ, Yin, M, Allen, R, Sidman, C, Proetzel, G and Calvin, D (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693-9 |
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| Abstract |
Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions. |
| Links |
PubMed Online version:10.1038/359693a0 |
| Keywords |
Animals; Base Sequence; Cytokines/genetics; Gene Expression; Genes; Homozygote; Inflammation/genetics; Inflammation/pathology; Leukocyte Count; Mice; Mice, Transgenic; Molecular Sequence Data; Mutagenesis, Insertional; Necrosis; Oligodeoxyribonucleotides/chemistry; Polymerase Chain Reaction; RNA, Messenger/genetics; Restriction Mapping; Transforming Growth Factor beta/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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