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PMID:22384214

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Citation

Simmons, T and Appel, B (2012) Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS ONE 7:e32317

Abstract

In vertebrates, the myelin sheath is essential for efficient propagation of action potentials along the axon shaft. Oligodendrocytes are the cells of the central nervous system that create myelin sheaths. During embryogenesis, ventral neural tube precursors give rise to oligodendrocyte progenitor cells, which divide and migrate throughout the central nervous system. This study aimed to investigate mechanisms that regulate oligodendrocyte progenitor cell formation.

Links

PubMed PMC3285679 Online version:10.1371/journal.pone.0032317

Keywords

Animals; Animals, Genetically Modified; Axons/metabolism; Cell Cycle; Cell Differentiation; Cell Lineage; Chromosome Mapping; Gene Expression Regulation; Green Fluorescent Proteins/metabolism; Models, Genetic; Mutagenesis; Mutation; Myelin Sheath/metabolism; Oligodendroglia/metabolism; Stem Cells/cytology; Zebrafish Proteins/genetics; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:PESC

GO:0014003: oligodendrocyte development

ECO:0000315:

P

Figure 2a & 2b. Loss of Pescadillo results in loss of dorsal oligodendrocytes

complete
CACAO 3904

DANRE:PESC

GO:0000084: S phase of mitotic cell cycle

ECO:0000315:

P

Figure 5b & 5c. Loss of pes function cells stayed in S phase

complete
CACAO 3905

DANRE:PESC

involved_in

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120330-4

P

Seeded From UniProt

complete

DANRE:PESC

involved_in

GO:0051726: regulation of cell cycle

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120330-4

P

Seeded From UniProt

complete

MOUSE:TGFB1

GO:0014003: oligodendrocyte development

ECO:0000315:

P

Figure 2a & Figure 2b. Loss of Pescadillo gene results in loss of dorsal oligodendrocytes.

complete
CACAO 3903

MOUSE:TGFB1

involved_in

GO:0014003: oligodendrocyte development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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