HUMAN:SMAD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMAD1 (synonyms: BSP1, MADH1, MADR1)
Protein Name(s)	Mothers against decapentaplegic homolog 1 MAD homolog 1 Mothers against DPP homolog 1 JV4-1 Mad-related protein 1 SMAD family member 1 SMAD 1 Smad1 hSMAD1 Transforming growth factor-beta-signaling protein 1 BSP-1
External Links
UniProt	Q15797
EMBL	U59912 U59423 U54826 U57456 BT007386 AK293055 AL117396 CH471056 CH471056 CH471056 CH471056 BC001878
CCDS	CCDS3765.1
PIR	S68987
RefSeq	NP_001003688.1 NP_005891.1 XP_005263048.1 XP_005263049.1 XP_006714280.1 XP_011530263.1 XP_011530264.1 XP_011530265.1 XP_011530266.1
UniGene	Hs.604588
PDB	1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A
PDBsum	1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A
ProteinModelPortal	Q15797
SMR	Q15797
BioGrid	110261
DIP	DIP-38538N
IntAct	Q15797
MINT	MINT-244113
STRING	9606.ENSP00000305769
PhosphoSite	Q15797
BioMuta	SMAD1
DMDM	13633915
MaxQB	Q15797
PaxDb	Q15797
PRIDE	Q15797
DNASU	4086
Ensembl	ENST00000302085 ENST00000394092 ENST00000515385
GeneID	4086
KEGG	hsa:4086
UCSC	uc003ikc.3
CTD	4086
GeneCards	GC04P146402
HGNC	HGNC:6767
HPA	CAB005389 CAB069411
MIM	601595
neXtProt	NX_Q15797
PharmGKB	PA30524
eggNOG	NOG330956
GeneTree	ENSGT00760000119091
HOGENOM	HOG000286019
HOVERGEN	HBG053353
InParanoid	Q15797
KO	K04676
OMA	MTHDTSQ
PhylomeDB	Q15797
TreeFam	TF314923
Reactome	REACT_12034
SignaLink	Q15797
EvolutionaryTrace	Q15797
GeneWiki	Mothers_against_decapentaplegic_homolog_1
GenomeRNAi	4086
NextBio	16014
PRO	PR:Q15797
Proteomes	UP000005640
Bgee	Q15797
CleanEx	HS_SMAD1
ExpressionAtlas	Q15797
Genevisible	Q15797
GO	GO:0005737 GO:0005829 GO:0016021 GO:0005622 GO:0005637 GO:0005654 GO:0005634 GO:0043234 GO:0005667 GO:0070410 GO:0070411 GO:0042802 GO:0046872 GO:0019901 GO:0005057 GO:0000978 GO:0001077 GO:0000979 GO:0003700 GO:0030618 GO:0030509 GO:0060348 GO:0060038 GO:0051216 GO:0071773 GO:0009880 GO:0007276 GO:0030902 GO:0042592 GO:0006954 GO:0000165 GO:0001710 GO:0030901 GO:0008285 GO:0002051 GO:0061036 GO:0010628 GO:0045669 GO:0045944 GO:1901522 GO:0031053 GO:0007165 GO:0007183 GO:0006366 GO:0007179 GO:0001657
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97454	F		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:24047927^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18548003^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	PMID:18548003^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RNAcentral:URS000018AA08_9606	F	part_of:(GO:0030509)	Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:18548003^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70340	C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70340	C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70340	P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70340	P	occurs_in:(UBERON:0002107) part_of:(GO:0030509)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70340	P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	PMID:14687659^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:14687659^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:12270938^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12270938^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12270938^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8653785^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0030513)	Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:9436979^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43541	F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	PMID:9111321^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19664780^[9]	ECO:0000305	curator inference used in manual assertion	GO:0010628	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9111321^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19664780^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:9389648^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19664780^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q13950)\|has_input:(UniProtKB:P10451)	Seeded From UniProt	complete
involved_in	GO:0007183	SMAD protein complex assembly	PMID:9111321^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9389648^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9389648^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9389648^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12874272^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H2X6	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:8663601^[12]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:8663601^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9759503^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:15647271^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9759503^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:8653785^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15231748^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11779505^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15797	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0007276	gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
involved_in	GO:0002051	osteoblast fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0001710	mesodermal cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	F		Seeded From UniProt	complete
involved_in	GO:0042592	homeostatic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70340 ensembl:ENSMUSP00000071035	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:0031053	primary miRNA processing	PMID:19018011^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	PMID:19018011^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19018011^[18] Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19018011^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6781764 Reactome:R-HSA-202626 Reactome:R-HSA-201648 Reactome:R-HSA-201476 Reactome:R-HSA-201472 Reactome:R-HSA-201453 Reactome:R-HSA-201445 Reactome:R-HSA-201422	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8878013 Reactome:R-HSA-8877941 Reactome:R-HSA-201472 Reactome:R-HSA-201425 Reactome:R-HSA-201423	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Icli, B et al. (2013) MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ. Res. 113 1231-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page
↑ ^6.0 ^6.1 Hoodless, PA et al. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85 489-500 PubMed GONUTS page
↑ Hata, A et al. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12 186-97 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wu, RY et al. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17 2521-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Yang, X et al. (2009) Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J. Thorac. Cardiovasc. Surg. 138 1008-15 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page
↑ Harada, J et al. (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J. Biol. Chem. 278 38998-9005 PubMed GONUTS page
↑ ^12.0 ^12.1 Lechleider, RJ et al. (1996) Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1. J. Biol. Chem. 271 17617-20 PubMed GONUTS page
↑ ^13.0 ^13.1 Massagué, J (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67 753-91 PubMed GONUTS page
↑ Pan, D et al. (2005) The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines. J. Biol. Chem. 280 15992-6001 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Colland, F et al. (2004) Functional proteomics mapping of a human signaling pathway. Genome Res. 14 1324-32 PubMed GONUTS page
↑ Qin, BY et al. (2001) Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell 8 1303-12 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:24047927-2] Icli, B et al. (2013) MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ. Res. 113 1231-41 PubMed GONUTS page

[PMID:18548003-3] 3.0 ^3.1 ^3.2 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page

[PMID:14687659-4] 4.0 ^4.1 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page

[PMID:12270938-5] 5.0 ^5.1 ^5.2 Zhang, W et al. (2002) Regulation of Hex gene expression by a Smads-dependent signaling pathway. J. Biol. Chem. 277 45435-41 PubMed GONUTS page

[PMID:8653785-6] 6.0 ^6.1 Hoodless, PA et al. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85 489-500 PubMed GONUTS page

[PMID:9436979-7] Hata, A et al. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12 186-97 PubMed GONUTS page

[PMID:9111321-8] 8.0 ^8.1 ^8.2 Wu, RY et al. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17 2521-8 PubMed GONUTS page

[PMID:19664780-9] 9.0 ^9.1 ^9.2 Yang, X et al. (2009) Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J. Thorac. Cardiovasc. Surg. 138 1008-15 PubMed GONUTS page

[PMID:9389648-10] 10.0 ^10.1 ^10.2 ^10.3 Liu, F et al. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11 3157-67 PubMed GONUTS page

[PMID:12874272-11] Harada, J et al. (2003) Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation. J. Biol. Chem. 278 38998-9005 PubMed GONUTS page

[PMID:8663601-12] 12.0 ^12.1 Lechleider, RJ et al. (1996) Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1. J. Biol. Chem. 271 17617-20 PubMed GONUTS page

[PMID:9759503-13] 13.0 ^13.1 Massagué, J (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67 753-91 PubMed GONUTS page

[PMID:15647271-14] Pan, D et al. (2005) The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines. J. Biol. Chem. 280 15992-6001 PubMed GONUTS page

[PMID:23610558-15] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:15231748-16] Colland, F et al. (2004) Functional proteomics mapping of a human signaling pathway. Genome Res. 14 1324-32 PubMed GONUTS page

[PMID:11779505-17] Qin, BY et al. (2001) Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell 8 1303-12 PubMed GONUTS page

[PMID:19018011-18] 18.0 ^18.1 ^18.2 ^18.3 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

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HUMAN:SMAD1

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