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Category:SMAD signaling

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Annotation of human SMAD signaling proteins started in Dec 2008 as part of the cardiovascular GO annotation initiative, at UCL. For more information please contact v.khodiyar"at"ucl.ac.uk

Aspect ID Term HUMAN

SMAD1

HUMAN

SMAD2

HUMAN

SMAD3

HUMAN

SMAD4

HUMAN

SMAD5

HUMAN

SMAD6

HUMAN

SMAD7

HUMAN

SMAD9

Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoter TAS IDA  IMP  TAS ISS  TAS IDA
Biological ProcessGO:0001666response to hypoxia IMP IMP
Biological ProcessGO:0001707mesoderm formation ISS
Biological ProcessGO:0001933negative regulation of protein phosphorylation IMP
Biological ProcessGO:0006351transcription, DNA-dependent IDA IDA  TAS IDA  TAS IDA  TAS TAS
Biological ProcessGO:0006355regulation of transcription, DNA-dependent IDA
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoter IDA
Biological ProcessGO:0006366transcription from RNA polymerase II promoter IDA
Biological ProcessGO:0006367transcription initiation from RNA polymerase II promoter TAS TAS TAS TAS
Biological ProcessGO:0006810transport IDA
Biological ProcessGO:0006879cellular iron ion homeostasis ISS
Biological ProcessGO:0006917induction of apoptosis IMP
Biological ProcessGO:0006919activation of caspase activity IMP
Biological ProcessGO:0006955immune response IMP IMP
Biological ProcessGO:0007050cell cycle arrest IMP
Biological ProcessGO:0007165signal transduction NAS NAS
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathway NAS IDA  IMP  TAS IDA  TAS IDA  ISS  TAS NAS TAS TAS
Biological ProcessGO:0007182common-partner SMAD protein phosphorylation IDA
Biological ProcessGO:0007183SMAD protein complex assembly IDA IDA IDA IDA
Biological ProcessGO:0007242intracellular signaling cascade ISS
Biological ProcessGO:0007352zygotic determination of dorsal/ventral axis IMP IMP
Biological ProcessGO:0007369gastrulation TAS
Biological ProcessGO:0008285negative regulation of cell proliferation IMP
Biological ProcessGO:0009880embryonic pattern specification ISS ISS
Biological ProcessGO:0009952anterior/posterior pattern formation ISS
Biological ProcessGO:0010467gene expression TAS TAS TAS TAS
Biological ProcessGO:0010553negative regulation of specific transcripti... IDA
Biological ProcessGO:0010628positive regulation of gene expression IDA IDA
Biological ProcessGO:0010718positive regulation of epithelial to mesenchymal transition ISS IDA  IMP ISS
Biological ProcessGO:0010719negative regulation of epithelial to mesenc... IC  TAS
Biological ProcessGO:0010801negative regulation of peptidyl-threonine p... IDA
Biological ProcessGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation ISS
Biological ProcessGO:0010944negative regulation of transcription by competitive promoter binding IDA
Biological ProcessGO:0010991negative regulation of SMAD protein complex assembly IDA
Biological ProcessGO:0017015regulation of transforming growth factor be... IMP IMP IMP IC
Biological ProcessGO:0019049evasion of host defenses by virus IDA
Biological ProcessGO:0022409positive regulation of cell-cell adhesion IDA
Biological ProcessGO:0030308negative regulation of cell growth IDA IDA
Biological ProcessGO:0030336negative regulation of cell migration TAS
Biological ProcessGO:0030509BMP signaling pathway IDA  IMP  ISS  TAS IDA  TAS ISS  TAS IDA  TAS TAS TAS
Biological ProcessGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway IDA
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway TAS TAS IMP IDA  TAS
Biological ProcessGO:0030513positive regulation of BMP signaling pathway IMP IMP
Biological ProcessGO:0030514negative regulation of BMP signaling pathway IDA IDA
Biological ProcessGO:0031053primary microRNA processing TAS TAS TAS
Biological ProcessGO:0031397negative regulation of protein ubiquitination IDA
Biological ProcessGO:0031398positive regulation of protein ubiquitination IDA
Biological ProcessGO:0031589cell-substrate adhesion IMP
Biological ProcessGO:0032436positive regulation of proteasomal ubiquiti... IDA
Biological ProcessGO:0032909regulation of transforming growth factor-be... IMP IMP
Biological ProcessGO:0032924activin receptor signaling pathway IMP IMP
Biological ProcessGO:0032925regulation of activin receptor signaling pa... IDA
Biological ProcessGO:0033137negative regulation of peptidyl-serine phos... IDA
Biological ProcessGO:0034333adherens junction assembly IMP
Biological ProcessGO:0034616response to laminar fluid shear stress IEP IEP
Biological ProcessGO:0034629cellular protein complex localization IDA
Biological ProcessGO:0035019somatic stem cell maintenance TAS TAS
Biological ProcessGO:0035413positive regulation of catenin import into nucleus IMP
Biological ProcessGO:0035556intracellular signal transduction ISS IDA IMP NAS  TAS IDA  IMP IDA TAS
Biological ProcessGO:0038092nodal signaling pathway IMP IMP
Biological ProcessGO:0042060wound healing TAS
Biological ProcessGO:0042177negative regulation of protein catabolic process IMP IMP
Biological ProcessGO:0042993positive regulation of transcription factor... IDA
Biological ProcessGO:0043066negative regulation of apoptosis IMP
Biological ProcessGO:0043154negative regulation of caspase activity IMP
Biological ProcessGO:0043433negative regulation of transcription factor... IDA
Biological ProcessGO:0045165cell fate commitment ISS
Biological ProcessGO:0045216cell-cell junction organization IMP
Biological ProcessGO:0045444fat cell differentiation IDA
Biological ProcessGO:0045750positive regulation of S phase of mitotic cell cycle IMP
Biological ProcessGO:0045768positive regulation of anti-apoptosis TAS
Biological ProcessGO:0045892negative regulation of transcription, DNA-d... IMP IDA
Biological ProcessGO:0045893positive regulation of transcription, DNA-dependent IDA  IMP  ISS IDA IDA NAS
Biological ProcessGO:0045930negative regulation of mitotic cell cycle IMP
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoter IC  IDA IDA  ISS  TAS IDA  IMP  TAS IDA  ISS  TAS TAS
Biological ProcessGO:0048340paraxial mesoderm morphogenesis ISS
Biological ProcessGO:0048844artery morphogenesis ISS
Biological ProcessGO:0050821protein stabilization IMP IDA
Biological ProcessGO:0051098regulation of binding ISS
Biological ProcessGO:0051444negative regulation of ubiquitin-protein li... IDA
Biological ProcessGO:0051571positive regulation of histone H3-K4 methylation ISS
Biological ProcessGO:0055010ventricular cardiac muscle morphogenesis ISS
Biological ProcessGO:0055117regulation of cardiac muscle contraction ISS
Biological ProcessGO:0060021palate development ISS ISS
Biological ProcessGO:0060373regulation of ventricular cardiomyocyte mem... IC
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylation ISS
Biological ProcessGO:0060391positive regulation of SMAD protein import into nucleus ISS
Biological ProcessGO:0060394negative regulation of pathway-restricted S... IDA  IMP IDA  TAS
Biological ProcessGO:0060395SMAD protein signal transduction NAS IDA NAS NAS
Biological ProcessGO:0060412ventricular septum morphogenesis ISS
Biological ProcessGO:0070102interleukin-6-mediated signaling pathway ISS
Biological ProcessGO:0070723response to cholesterol IDA
Biological ProcessGO:0071559response to transforming growth factor beta stimulus IDA
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulus IMP
Biological ProcessGO:0071773cellular response to BMP stimulus ISS NAS ISS NAS
Biological ProcessGO:0090263positive regulation of canonical Wnt receptor signaling pathway IMP
Biological ProcessGO:0097191extrinsic apoptotic signaling pathway IMP
Biological ProcessGO:1900224positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IMP
Biological ProcessGO:1901203positive regulation of extracellular matrix assembly IDA
Biological ProcessGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus ISS TAS ISS  TAS TAS
Biological ProcessGO:2000617positive regulation of histone H3-K9 acetylation ISS
Cellular ComponentGO:0000790nuclear chromatin IDA IDA IDA
Cellular ComponentGO:0005622intracellular NAS ISS NAS TAS
Cellular ComponentGO:0005634nucleus IDA  NAS  TAS IDA IDA IDA NAS  TAS IDA IDA TAS
Cellular ComponentGO:0005637nuclear inner membrane IDA IDA
Cellular ComponentGO:0005654nucleoplasm TAS TAS IDA  TAS IDA  TAS IDA  TAS TAS IDA  TAS
Cellular ComponentGO:0005667transcription factor complex IDA IDA IDA  IPI
Cellular ComponentGO:0005730nucleolusNOT IDA IDA NOT IDA
Cellular ComponentGO:0005737cytoplasm IDA IDA IDA IDA IDA TAS IDA IDA
Cellular ComponentGO:0005813centrosome IDA IDA
Cellular ComponentGO:0005886plasma membrane IDA
Cellular ComponentGO:0005913cell-cell adherens junctioncolocalizes_with IDA
Cellular ComponentGO:0016021integral to membrane NAS NAS
Cellular ComponentGO:0016342catenin complexcolocalizes_with IDA
Cellular ComponentGO:0032444activin responsive factor complex IDA IDA
Cellular ComponentGO:0043234protein complex IDA IDA IDA IDA
Cellular ComponentGO:0043235receptor complex IMP
Cellular ComponentGO:0071141SMAD protein complex NAS IDA IDA IDA NAS NAS
Cellular ComponentGO:0071144SMAD2-SMAD3 protein complex IDA IDA
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA IDA IDA IDA IDA
Molecular FunctionGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific IDA
Molecular FunctionGO:0000987core promoter proximal region sequence-specific DNA binding IDA IDA
Molecular FunctionGO:0000988transcription factor activity, protein bindingcontributes_to IDAcontributes_to IDA
Molecular FunctionGO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA IDA IDA
Molecular FunctionGO:0001102RNA polymerase II activating transcription factor binding IPI
Molecular FunctionGO:0003677DNA bindingcontributes_to IDAcontributes_to IDA
Molecular FunctionGO:0003682chromatin binding IDA
Molecular FunctionGO:0003690double-stranded DNA binding ISS
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activity IDA IDA contributes_to IDA IDA contributes_to IDAcontributes_to IDA
Molecular FunctionGO:0005057receptor signaling protein activity NAS NAS
Molecular FunctionGO:0005160transforming growth factor beta receptor binding IPI IPI
Molecular FunctionGO:0005515protein binding IPI IPI IPI IPI IPI IPI IPI IPI
Molecular FunctionGO:0008013beta-catenin binding IPI IPI
Molecular FunctionGO:0008134transcription factor binding IPI IPI
Molecular FunctionGO:0008270zinc ion binding IDA
Molecular FunctionGO:0010843promoter binding IDA IDA IDA IDA
Molecular FunctionGO:0015460transport accessory protein activity IDA
Molecular FunctionGO:0016563transcription activator activity NAS ISS NAS
Molecular FunctionGO:0019901protein kinase binding IPI IPI
Molecular FunctionGO:0019902phosphatase binding IPI IPI
Molecular FunctionGO:0030616transforming growth factor beta receptor, c... IDA
Molecular FunctionGO:0030617transforming growth factor beta receptor, i... IDA  IMP IDA
Molecular FunctionGO:0030618transforming growth factor beta receptor, p... TAS IDA IDA TAS TAS
Molecular FunctionGO:0031625ubiquitin protein ligase binding IPI IPI IPI IPI IPI IPI
Molecular FunctionGO:0033613activating transcription factor binding IPI
Molecular FunctionGO:0034713type I transforming growth factor beta rece... IPI IDA IPI
Molecular FunctionGO:0035326enhancer binding IC IC
Molecular FunctionGO:0042301phosphate binding IPI
Molecular FunctionGO:0042802identical protein binding IPI IPI IPI IPI
Molecular FunctionGO:0042803protein homodimerization activity IPI IPI IPI
Molecular FunctionGO:0043130ubiquitin binding IPI IDA  IPI IDA
Molecular FunctionGO:0043425bHLH transcription factor binding IPI
Molecular FunctionGO:0043565sequence-specific DNA binding IDAcontributes_to IDA
Molecular FunctionGO:0044212transcription regulatory region DNA binding IDA IDA IDA IDA
Molecular FunctionGO:0046332SMAD binding IPI IPI IPI IPI IPI IPI
Molecular FunctionGO:0048185activin binding IPI
Molecular FunctionGO:0070410co-SMAD binding IPI IPI IPI IPI
Molecular FunctionGO:0070411I-SMAD binding IPI IPI IPI IPI IPI
Molecular FunctionGO:0070412R-SMAD binding IPI IPI IPI IPI
Molecular FunctionGO:0070698type I activin receptor binding IDA
Cellular ComponentGO:0005829cytosol EXP  TAS EXP  TAS EXP  TAS EXP  TAS EXP  TAS EXP  TAS EXP  TAS EXP  TAS

Cellular Component graph



RefGenome graph at MGI.


Molecular Function graph



RefGenome graph at MGI.


Biological Process graph



RefGenome graph at MGI.



References

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Pages in category "SMAD signaling"

The following 8 pages are in this category, out of 8 total.