HUMAN:SMAD7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMAD7 (synonyms: MADH7, MADH8)
Protein Name(s)	Mothers against decapentaplegic homolog 7 MAD homolog 7 Mothers against DPP homolog 7 Mothers against decapentaplegic homolog 8 MAD homolog 8 Mothers against DPP homolog 8 SMAD family member 7 SMAD 7 Smad7 hSMAD7
External Links
UniProt	O15105
EMBL	AF010193 AF015261 AF026559 AF026556 AF026557 AF026558 AK301535 DA882147 AC114684 BC074818 BC074819
CCDS	CCDS11936.1 CCDS54186.1 CCDS59317.1
RefSeq	NP_001177750.1 NP_001177751.1 NP_001177752.1 NP_005895.1
UniGene	Hs.465087
PDB	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
PDBsum	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
ProteinModelPortal	O15105
SMR	O15105
BioGrid	110267
DIP	DIP-42252N
IntAct	O15105
MINT	MINT-1179821
STRING	9606.ENSP00000262158
PhosphoSite	O15105
BioMuta	SMAD7
PaxDb	O15105
PRIDE	O15105
Ensembl	ENST00000262158 ENST00000589634 ENST00000591805
GeneID	4092
KEGG	hsa:4092
UCSC	uc002ldg.3 uc010xde.2
CTD	4092
GeneCards	GC18M046446
HGNC	HGNC:6773
HPA	CAB026212 HPA028897
MIM	602932 612229
neXtProt	NX_O15105
PharmGKB	PA134875286
eggNOG	NOG309572
GeneTree	ENSGT00760000119091
HOGENOM	HOG000060106
HOVERGEN	HBG053021
InParanoid	O15105
KO	K04677
OMA	GQLCSEN
OrthoDB	EOG7GN2PK
PhylomeDB	O15105
TreeFam	TF314923
Reactome	REACT_12034 REACT_120727 REACT_120734
SignaLink	O15105
ChiTaRS	SMAD7
EvolutionaryTrace	O15105
GeneWiki	Mothers_against_decapentaplegic_homolog_7
GenomeRNAi	4092
NextBio	16046
PRO	PR:O15105
Proteomes	UP000005640
Bgee	O15105
CleanEx	HS_SMAD7
ExpressionAtlas	O15105
Genevisible	O15105
GO	GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005886 GO:0043234 GO:0005667 GO:0048185 GO:0008013 GO:0070411 GO:0046872 GO:0003700 GO:0044212 GO:0030617 GO:0034713 GO:0031625 GO:0034333 GO:0048844 GO:0030509 GO:0034629 GO:0071560 GO:0010467 GO:0035556 GO:0030514 GO:0030336 GO:0010719 GO:0060394 GO:0033137 GO:0010801 GO:0031397 GO:0043433 GO:0010944 GO:0000122 GO:0030512 GO:0051444 GO:0060389 GO:0022409 GO:0032436 GO:0031398 GO:0045944 GO:0050821 GO:0032925 GO:0055117 GO:0017015 GO:0060373 GO:0034616 GO:0006367 GO:0006351 GO:0007179 GO:0001657 GO:0055010 GO:0060412
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000317	negative regulation of T-helper 17 type immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
involved_in	GO:2000320	negative regulation of T-helper 17 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P	occurs_in:(CL:0000492)	Seeded From UniProt	complete
involved_in	GO:0002725	negative regulation of T cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P	occurs_in:(CL:0000492) has_regulation_target:(UniProtKB:Q62386)	Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	PMID:24887517^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97454	F		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:9256479^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43541	F		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
involved_in	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:18952608^[5]	ECO:0000305	curator inference used in manual assertion	GO:0055010	P		Seeded From UniProt	complete
involved_in	GO:0055117	regulation of cardiac muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35253	P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:16720724^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36896	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	PMID:11278251^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0034629	cellular protein-containing complex localization	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	PMID:9256479^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P35222)	Seeded From UniProt	complete
involved_in	GO:0032925	regulation of activin receptor signaling pathway	PMID:16720724^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:11278251^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:12151385^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:16720724^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	PMID:9256479^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:12151385^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:18762808^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	PMID:18952608^[5]	ECO:0000305	curator inference used in manual assertion	GO:0060389	P		Seeded From UniProt	complete
colocalizes_with	GO:0016342	catenin complex	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P35222)	Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:18762808^[9]	ECO:0000305	curator inference used in manual assertion	GO:0030512	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:18593713^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
colocalizes_with	GO:0005913	cell-cell adherens junction	PMID:18593713^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12151385^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11278251^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12151385^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11278251^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17438144^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000320	negative regulation of T-helper 17 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:2000317	negative regulation of T-helper 17 type immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0055117	regulation of cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	C		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	F		Seeded From UniProt	complete
involved_in	GO:0002725	negative regulation of T cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35253 ensembl:ENSMUSP00000026999	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	PMID:19018011^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:19018011^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010719	negative regulation of epithelial to mesenchymal transition	PMID:19018011^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173796	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173788 Reactome:R-HSA-173512 Reactome:R-HSA-173483	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6781764 Reactome:R-HSA-2169046 Reactome:R-HSA-2128994 Reactome:R-HSA-202626 Reactome:R-HSA-201821 Reactome:R-HSA-201475 Reactome:R-HSA-173512 Reactome:R-HSA-173483	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-2186780 Reactome:R-HSA-2186771 Reactome:R-HSA-2106591 Reactome:R-HSA-178208	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, JY et al. (2014) miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol. Cell. Endocrinol. 392 163-72 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Topper, JN et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 94 9314-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page
↑ ^5.0 ^5.1 Chen, Q et al. (2009) Smad7 is required for the development and function of the heart. J. Biol. Chem. 284 292-300 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yamaguchi, T et al. (2006) FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 36 569-79 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Suzuki, C et al. (2002) Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277 39919-25 PubMed GONUTS page
↑ ^9.0 ^9.1 Wang, H et al. (2008) Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Oncogene 27 6791-805 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

[PMID:24887517-1] Wang, JY et al. (2014) miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol. Cell. Endocrinol. 392 163-72 PubMed GONUTS page

[PMID:18593713-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page

[PMID:9256479-3] 3.0 ^3.1 ^3.2 Topper, JN et al. (1997) Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl. Acad. Sci. U.S.A. 94 9314-9 PubMed GONUTS page

[PMID:17438144-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Zhang, S et al. (2007) Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol. Cell. Biol. 27 4488-99 PubMed GONUTS page

[PMID:18952608-5] 5.0 ^5.1 Chen, Q et al. (2009) Smad7 is required for the development and function of the heart. J. Biol. Chem. 284 292-300 PubMed GONUTS page

[PMID:16720724-6] 6.0 ^6.1 ^6.2 Yamaguchi, T et al. (2006) FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 36 569-79 PubMed GONUTS page

[PMID:11278251-7] 7.0 ^7.1 ^7.2 ^7.3 Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page

[PMID:12151385-8] 8.0 ^8.1 ^8.2 ^8.3 Suzuki, C et al. (2002) Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277 39919-25 PubMed GONUTS page

[PMID:18762808-9] 9.0 ^9.1 Wang, H et al. (2008) Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55. Oncogene 27 6791-805 PubMed GONUTS page

[PMID:23610558-10] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:19018011-11] 11.0 ^11.1 ^11.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

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HUMAN:SMAD7

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