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HUMAN:SMAD5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SMAD5 (synonyms: MADH5)
Protein Name(s) Mothers against decapentaplegic homolog 5

MAD homolog 5 Mothers against DPP homolog 5 JV5-1 SMAD family member 5 SMAD 5 Smad5 hSmad5

External Links
UniProt Q99717
EMBL U59913
AF010601
AF010607
AF010602
AF010603
AF010604
AF010605
AF010606
U73825
AF009744
AF009739
AF009740
AF009741
AF009742
AF009743
AF009678
BC009682
CCDS CCDS75308.1
RefSeq NP_001001419.1
NP_001001420.1
NP_005894.3
UniGene Hs.167700
ProteinModelPortal Q99717
SMR Q99717
BioGrid 110265
DIP DIP-57571N
IntAct Q99717
MINT MINT-1180224
STRING 9606.ENSP00000441954
PhosphoSite Q99717
BioMuta SMAD5
DMDM 13959566
MaxQB Q99717
PaxDb Q99717
PRIDE Q99717
DNASU 4090
Ensembl ENST00000545279
ENST00000545620
GeneID 4090
KEGG hsa:4090
UCSC uc003lbj.1
CTD 4090
GeneCards GC05P135470
HGNC HGNC:6771
HPA HPA058931
MIM 603110
neXtProt NX_Q99717
PharmGKB PA30528
eggNOG NOG330956
GeneTree ENSGT00760000119091
HOVERGEN HBG053353
InParanoid Q99717
KO K16790
OMA DVQPVEY
PhylomeDB Q99717
Reactome REACT_12034
SignaLink Q99717
ChiTaRS SMAD5
GeneWiki Mothers_against_decapentaplegic_homolog_5
GenomeRNAi 4090
NextBio 16034
PRO PR:Q99717
Proteomes UP000005640
Bgee Q99717
CleanEx HS_SMAD5
ExpressionAtlas Q99717
Genevisible Q99717
GO GO:0005737
GO:0005829
GO:0016021
GO:0005622
GO:0005654
GO:0005634
GO:0043234
GO:0005667
GO:0046872
GO:0005057
GO:0000979
GO:0003700
GO:0030618
GO:0031625
GO:0030509
GO:0060348
GO:0060048
GO:0051216
GO:0071773
GO:0071407
GO:0009880
GO:0030218
GO:0007281
GO:0035556
GO:0001880
GO:0002051
GO:0045669
GO:1901522
GO:0045893
GO:0006468
GO:0007165
GO:0006351
GO:0007179
GO:0001657
Gene3D 2.60.200.10
3.90.520.10
InterPro IPR013790
IPR003619
IPR013019
IPR017855
IPR001132
IPR008984
PANTHER PTHR13703
Pfam PF03165
PF03166
SMART SM00523
SM00524
SUPFAM SSF49879
SSF56366
PROSITE PS51075
PS51076

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

F

Seeded From UniProt

complete

enables

GO:0017151

DEAD/H-box RNA helicase binding

PMID:18548003[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P17844

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97454

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97454

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

involved_in

GO:1901522

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97454

P

part_of:(GO:0071773)

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97454

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97454

P

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0071141

SMAD protein complex

PMID:14687659[3]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

PMID:14687659[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

part_of:(GO:0071773)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P97454

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:11278251[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9HCE7

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10708949[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9W7E7

P

Seeded From UniProt

complete

involved_in

GO:0009880

embryonic pattern specification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9W7E7

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:10708948[6]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9759503[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9759503[7]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:23610558[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1901522

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0071773

cellular response to BMP stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060395

SMAD protein signal transduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060348

bone development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0060048

cardiac muscle contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0007281

germ cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

C

Seeded From UniProt

complete

involved_in

GO:0002051

osteoblast fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97454
ensembl:ENSMUSP00000065798

P

Seeded From UniProt

complete

involved_in

GO:0001880

Mullerian duct regression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R1V3
ensembl:ENSRNOP00000016704

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9R1V3
ensembl:ENSRNOP00000016704

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

F

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001132
InterPro:IPR003619
InterPro:IPR013019
InterPro:IPR013790

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013019
InterPro:IPR036578

P

Seeded From UniProt

complete

involved_in

GO:1901522

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

PMID:14687659[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

part_of:(GO:0071773)

Seeded From UniProt

complete

enables

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

PMID:19018011[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:19018011[9]
Reactome:R-HSA-201451

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19018011[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-202626
Reactome:R-HSA-201648
Reactome:R-HSA-201476
Reactome:R-HSA-201472
Reactome:R-HSA-201453
Reactome:R-HSA-201445
Reactome:R-HSA-201422

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-201472
Reactome:R-HSA-201425
Reactome:R-HSA-201423

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes


References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
  3. 3.0 3.1 3.2 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page
  4. Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page
  5. Miyazono, K () TGF-beta signaling by Smad proteins. Cytokine Growth Factor Rev. 11 15-22 PubMed GONUTS page
  6. Wrana, JL & Attisano, L () The Smad pathway. Cytokine Growth Factor Rev. 11 5-13 PubMed GONUTS page
  7. 7.0 7.1 Massagué, J (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67 753-91 PubMed GONUTS page
  8. Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
  9. 9.0 9.1 9.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page