HUMAN:SMAD5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SMAD5 (synonyms: MADH5)
Protein Name(s)	Mothers against decapentaplegic homolog 5 MAD homolog 5 Mothers against DPP homolog 5 JV5-1 SMAD family member 5 SMAD 5 Smad5 hSmad5
External Links
UniProt	Q99717
EMBL	U59913 AF010601 AF010607 AF010602 AF010603 AF010604 AF010605 AF010606 U73825 AF009744 AF009739 AF009740 AF009741 AF009742 AF009743 AF009678 BC009682
CCDS	CCDS75308.1
RefSeq	NP_001001419.1 NP_001001420.1 NP_005894.3
UniGene	Hs.167700
ProteinModelPortal	Q99717
SMR	Q99717
BioGrid	110265
DIP	DIP-57571N
IntAct	Q99717
MINT	MINT-1180224
STRING	9606.ENSP00000441954
PhosphoSite	Q99717
BioMuta	SMAD5
DMDM	13959566
MaxQB	Q99717
PaxDb	Q99717
PRIDE	Q99717
DNASU	4090
Ensembl	ENST00000545279 ENST00000545620
GeneID	4090
KEGG	hsa:4090
UCSC	uc003lbj.1
CTD	4090
GeneCards	GC05P135470
HGNC	HGNC:6771
HPA	HPA058931
MIM	603110
neXtProt	NX_Q99717
PharmGKB	PA30528
eggNOG	NOG330956
GeneTree	ENSGT00760000119091
HOVERGEN	HBG053353
InParanoid	Q99717
KO	K16790
OMA	DVQPVEY
PhylomeDB	Q99717
Reactome	REACT_12034
SignaLink	Q99717
ChiTaRS	SMAD5
GeneWiki	Mothers_against_decapentaplegic_homolog_5
GenomeRNAi	4090
NextBio	16034
PRO	PR:Q99717
Proteomes	UP000005640
Bgee	Q99717
CleanEx	HS_SMAD5
ExpressionAtlas	Q99717
Genevisible	Q99717
GO	GO:0005737 GO:0005829 GO:0016021 GO:0005622 GO:0005654 GO:0005634 GO:0043234 GO:0005667 GO:0046872 GO:0005057 GO:0000979 GO:0003700 GO:0030618 GO:0031625 GO:0030509 GO:0060348 GO:0060048 GO:0051216 GO:0071773 GO:0071407 GO:0009880 GO:0030218 GO:0007281 GO:0035556 GO:0001880 GO:0002051 GO:0045669 GO:1901522 GO:0045893 GO:0006468 GO:0007165 GO:0006351 GO:0007179 GO:0001657
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	F		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:18548003^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97454	C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97454	C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97454	P	part_of:(GO:0071773)	Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97454	P	occurs_in:(UBERON:0002107) part_of:(GO:0030509)	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97454	P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	PMID:14687659^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	PMID:14687659^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97454	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11278251^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HCE7	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10708949^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9W7E7	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10708948^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9759503^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9759503^[7]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0060395	SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	C		Seeded From UniProt	complete
involved_in	GO:0002051	osteoblast fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97454 ensembl:ENSMUSP00000065798	P		Seeded From UniProt	complete
involved_in	GO:0001880	Mullerian duct regression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1V3 ensembl:ENSRNOP00000016704	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1V3 ensembl:ENSRNOP00000016704	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	PMID:14687659^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0071773)	Seeded From UniProt	complete
enables	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	PMID:19018011^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19018011^[9] Reactome:R-HSA-201451	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19018011^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-202626 Reactome:R-HSA-201648 Reactome:R-HSA-201476 Reactome:R-HSA-201472 Reactome:R-HSA-201453 Reactome:R-HSA-201445 Reactome:R-HSA-201422	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-201472 Reactome:R-HSA-201425 Reactome:R-HSA-201423	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page
↑ Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page
↑ Miyazono, K () TGF-beta signaling by Smad proteins. Cytokine Growth Factor Rev. 11 15-22 PubMed GONUTS page
↑ Wrana, JL & Attisano, L () The Smad pathway. Cytokine Growth Factor Rev. 11 5-13 PubMed GONUTS page
↑ ^7.0 ^7.1 Massagué, J (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67 753-91 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:18548003-2] Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page

[PMID:14687659-3] 3.0 ^3.1 ^3.2 Nohe, A et al. (2004) Signal transduction of bone morphogenetic protein receptors. Cell. Signal. 16 291-9 PubMed GONUTS page

[PMID:11278251-4] Ebisawa, T et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 12477-80 PubMed GONUTS page

[PMID:10708949-5] Miyazono, K () TGF-beta signaling by Smad proteins. Cytokine Growth Factor Rev. 11 15-22 PubMed GONUTS page

[PMID:10708948-6] Wrana, JL & Attisano, L () The Smad pathway. Cytokine Growth Factor Rev. 11 5-13 PubMed GONUTS page

[PMID:9759503-7] 7.0 ^7.1 Massagué, J (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67 753-91 PubMed GONUTS page

[PMID:23610558-8] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:19018011-9] 9.0 ^9.1 ^9.2 Hoover, LL & Kubalak, SW (2008) Holding their own: the noncanonical roles of Smad proteins. Sci Signal 1 pe48 PubMed GONUTS page

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HUMAN:SMAD5

Contents

Annotations

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References

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